In Parkinson’s, a protein called alpha-synuclein which is abundant in nerve cells, begins clumping together (or aggregating) and it is believed that this process could be toxic. Anle138b is a small molecule that has been developed, by the German biotech company MODAG, to inhibit alpha-synuclein aggregation; and it is hoped that this treatment will slow-down or halt the progression of Parkinson’s.
Anle138b to target the toxic protein in P... - Cure Parkinson's
Anle138b to target the toxic protein in Parkinson’s
Written by
SuzeCP
Partner
To view profiles and participate in discussions please or .
7 Replies
•
scienceofparkinsons.com/202...
Ponieboy• in reply to
Good read.. perhaps something will come out of it soon.
Haven't they run out of "mice models" yet?
That's interesting. Until this is shown to help PwPs and becomes available, I wonder whether it gives more credence to the use of curcumin which has also been shown to lessen the clumping of alpha-synuclein in vitro and in mouse models?
Interesting article. Keep the information coming. Thanks for sharing
Not what you're looking for?
You may also like...
Copper Leads to Protein Aggregation in Parkinson’s Disease
@[213807] found this! Copper Leads to Protein Aggregation in Parkinson’s Disease July 7 2022...
Researchers in Japan have developed a technique to visualize how an abnormal protein accumulates in brains of PP patients
This is an important development
It has been known that a protein called alpha-synuclein builds up...
Nano-plastics affect a specific protein found in the brain, causing changes linked to Parkinson’s disease and other types of dementia.
Researchers from Duke University School of Medicine found that nano-plastics — extremely small...
LL-37, a natural antimicrobial molecule present in the brain and gut, Suppresses Alpha-synuclein Clumping in Parkinson’s
"LL-37, a natural antimicrobial molecule present in the brain and gut, selectively binds to harmful...
Natural Kaempferol Delays Parkinson’s Symptoms in Fruit Fly Model
Natural Kaempferol Delays Parkinson’s Symptoms in Fruit Fly Model 2020...