Lactiplantibacillus (Lactobacillus) plant... - Cure Parkinson's

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Lactiplantibacillus (Lactobacillus) plantarum PS128

delboy381 profile image

Before I share briefly my experience with PS128 I want to emphasize that this probiotic may not have the same effect on everyone, as we know we are all different.

For four years I have been looking for something to help me with my symptoms. Many of the supplements I use have not given any specific relief until the probiotic Lactiplantibacillus (Lactobacillus) Plantarum PS128, which I felt the other day.

It is not a placebo to immediately dismiss this dilemma because I know this matter very well. My brief experience with the PS128 is 7 days. I know it's too early for some conclusions about its effectiveness, but I couldn't bear to share this news with you. I won’t write much about probiotics. I will put the website so that you can read it for yourself.

benedbiomed.com/

ps128.info/clinical-pd

I know this probiotic has already been mentioned here, but I want to share my experience with it.

I consume the powder 1.5 gr before meals. Active ingredient ps128 30 billion live bacteria. This is a revolutionary psychobiotic.

What relief did I notice with the symptoms:

A clearer head 80%

Tremor 70%

Anxiety 80%

Fatigue 80%

Motor skills 70%

At the end of the post, a quote I read on this site:

Parkinson’s attacks the mind, body, and spirit. Hope treats all three.

- Gordon Adai

153 Replies

Glad that it is working for you. I gave it to my mother for 7 weeks and it made no difference.

I'm sorry to hear that. Like I said we are all different and the way we developed this unhealthiness. How long has mom had Pd? And what are her main symptoms?

She has PD since 11 years now. Gave it to her( 60 billion dose/day) almost a year and a half back and did not make a difference. It was from Solace Probiotic, same strain - PS128. (see link below).

She has almost all the typical symptoms associated with PD - constipation - now manageable, balance and gait issues, freezing before walking, anxiety, confusion, fatigue and tremors. But she sleeps well, eats well, can walk for a furlong without stopping if and when she is in the mood - (which is rare).

solaceprobiotic.com/product...

John, did she take 60 billion a day? That is the dose in the clinical trial and that is what my husband has been taking since June.

Fed1000 profile image
Fed1000 in reply to Millbrook

Hi Millbrook, which kind of product are you using?

Millbrook profile image
Millbrook in reply to Fed1000

Basically I emailed Benedbiomed and asked them for their supplier in Asia.

the website is wellbeingsg.com

Product is called ACTIV health multibiotics containing PS128 +K21

My husband takes 2 sachets according to the clinical trial.

The best thing is to email Benedbiomed, and ask them where you can purchase it. You want the same product. They can name it whatever they like. It is a life changer.

Fed1000 profile image
Fed1000 in reply to Millbrook

Perfect. Thank you very much.

OAFC profile image
OAFC in reply to Millbrook

Is this the one Millbrook?? If so it is selling for $10 now in a 1 for 1 deal.Shipping to the UK is $90

Clear
Millbrook profile image
Millbrook in reply to OAFC

Yes this is the one. Wow S$10 is a steal. It works out to £5 a box excluding shipping. Is the expiry Dec 2021?Everyone who wants to try order this now. It’s a giveaway. It wd be good to order the maximum amount that the £40 shipping cost can allow you.

Thank you for posting the image. I did not know how to do it.

OAFC profile image
OAFC in reply to Millbrook

You’re welcome and yes it’s a bargain and worth a try..Not sure how long delivery takes..Thank you for sharing 🙏

Millbrook profile image
Millbrook in reply to OAFC

You are most welcome and I wish everyone gets the same great results.

OAFC profile image
OAFC in reply to Millbrook

Did it help your husband with Tremors and Dystonia as these are the major symptoms I suffer from predominantly all left sided Very painful Dystonia with my toes, fingers and hand cramping and curling in on themselves and severe tremors in my foot and hand 🙏

Millbrook profile image
Millbrook in reply to OAFC

If you refer to delboy381’s post he said it helped with tremors amongst other things.My husband does not have tremors. He had akinesia-slowness of movt- and balance was a really big thing and he was prone to tripping and falling. So with PS128 his balance was normalised, no more akinesia.

Unlike delboy who cd perceive the difference when taking PS 128, my husband cannot give any feedback. As caregiver I see the improvements.

His driving also improved tremendously, anxiety, sleep all improved as did nocturia

OAFC profile image
OAFC in reply to Millbrook

So happy for you and your husband I hope it helps me with my Tremors and Dystonia as they are really awful at the moment 😞😞One can only try and 😯prey and hope for the best 🙏

OAFC profile image
OAFC in reply to Millbrook

👍🙏

Clear
Buckholt profile image
Buckholt in reply to Millbrook

Best before shown as 18 Dec 2021 so only one month in date once received.

JAS9 profile image
JAS9 in reply to Millbrook

Yes, but I'm in the US and when I go to their website to buy it, there's no shipping option for the US. I suppose it has to do with politics, the pandemic, or the broken supply chain, but that's all beyond my control. Maybe I'll have to row my little boat there!

Millbrook profile image
Millbrook in reply to JAS9

You can message them on what’s app with yr queries. ACTIV health singapore

+65 8862 9039

rebtar profile image
rebtar in reply to OAFC

What do you mean 1 for 1 deal?

OAFC profile image
OAFC in reply to rebtar

Buy 1 and get another 1 free

Millbrook profile image
Millbrook in reply to OAFC

Hi OAFC. At S$10 a box there is no one for one deal. When it was S$45, I got the one for one deal.

OAFC profile image
OAFC in reply to Millbrook

Hi I ordered one at $10 and received 2 boxes

Millbrook profile image
Millbrook in reply to OAFC

Hi. When I ordered I got the one for one deal too at $10. So when I ordered 11 boxes I got 22. So lovely. 😃

60 Billion per day, not million.

That's incredible ! Once I research this I will try it. Where can this be purchased ? Thanks

delboy381 profile image
delboy381 in reply to KERRINGTON

Since I live in Europe This powder in sachets is produced in Italy for Bened Biomedical LTD. Company named: Farcoderma I will put a link below.

Someone put here that Solar sells in capsules. Try to find it on Amazon.

The name of the product I use is Second Brain. It looks like this...

farcoderma.com/en/

.
Fed1000 profile image
Fed1000 in reply to delboy381

Hi delboy, how did you by it? From Serbia? Does not seem very simple. The name of the product is Solace or Second Brain? Thanks

delboy381 profile image
delboy381 in reply to Fed1000

Yes, through Serbia. I asked a question Millbrook. Which brand to buy and where.

I bought Swansons L-Plantera from a Dutch Company. Would be interesting to see if that works for you. Much cheaper. The company is called Body&Fit.

Now for now I will use this brand, time will tell. Thanks for the comment.

KERRINGTON profile image
KERRINGTON in reply to delboy381

I ordered ps 128 from Solace, and it arrived fast. It came packaged with a cold pack. Starting it today.

delboy381 profile image
delboy381 in reply to KERRINGTON

I hope you will have benefits. I wish you all the best. It's all up to us.

KERRINGTON profile image
KERRINGTON in reply to delboy381

👍

Search coming up empty. What is the secret to obtaining this?

delboy381 profile image
delboy381 in reply to park_bear

I don't understand the question?

park_bear profile image
park_bear in reply to delboy381

Never mind. Found it. Not cheap. Tempted to give it a try on your recommendation:

solaceprobiotic.com/product...

delboy381 profile image
delboy381 in reply to park_bear

It is a very expensive Solace product.

OAFC profile image
OAFC in reply to park_bear

Found this on Amazon,Not sure if it’s any good but maybe worth a try at the price it is ??

Clear
Fed1000 profile image
Fed1000 in reply to OAFC

This is not delboy's product. This is made in France. I've been using it for a few months with no results.

OAFC profile image
OAFC in reply to Fed1000

Yeh I know it’s not the same products as Delboys I just put it on for info and for the price of it…It actually says it’s got the same amount of PS128 in it..Sorry it hasn’t worked for you but like Delboy says everybody’s different and certain things work for one person but not another..Unfortunately that’s the problem with this Godforsaken disease

OAFC profile image
OAFC in reply to park_bear

More info

More info
park_bear profile image
park_bear in reply to OAFC

This product does not seem to be available in the US

OAFC profile image
OAFC in reply to park_bear

See earlier post from “Millbrook” for the one her husband uses with great success and the company she gets it from They’re selling a pack for $10 at the moment due to going out of date soon..I’ve just ordered 2 boxes and they ship all over the world..I’m in the UK

glenandgerry profile image
glenandgerry in reply to OAFC

Any idea how much you'll have to pay for import duty and tax into the UK?

OAFC profile image
OAFC in reply to glenandgerry

The total cost for everything is £54

OAFC profile image
OAFC in reply to park_bear

This is the one “Millbrook” gives to her husband

Clear
OAFC profile image
OAFC in reply to park_bear

👍

Clear
OAFC profile image
OAFC in reply to park_bear

wellbeingsg.com/product/mul... This is the Link 👍

park_bear profile image
park_bear in reply to OAFC

Yes that is a possibility. They do want $50 US to ship from Singapore.

OAFC profile image
OAFC in reply to park_bear

Yeh it’s costing me £40 to get it delivered to the UK…If it helps dramatically though that will be a small price to pay 🙏🙏

Buckholt profile image
Buckholt in reply to park_bear

Best before shown as 18 Dec 2021 so only one month in date once received.

FawnLily profile image
FawnLily in reply to park_bear

$50? They want $70 for shipping to me and I am on west coast 🤔

park_bear profile image
park_bear in reply to FawnLily

That is in Singaporean dollars. They are worth US$.75, which comes to a bit more than $50 US.

Was this for one box? I put in two boxes and shipping is $103 US dollars to arizona.

JeanieBeanie profile image
JeanieBeanie in reply to OAFC

Thank you. Just ordered 4 boxes and cost £62 I think with delivery to uk. Will try this and see how it compares to Swansons.

OAFC profile image
OAFC in reply to JeanieBeanie

Good Luck 🙏

Solace is very expensive when compared to wellbeingsg.com. I have been wanting to buy it but couldn’t get past the price on solace. I just bought 6 months worth ( 12 boxes) from the wellbeingsg.com for about the same price as 3 boxes from solace. I’m hoping it is worth it!

Fingers crossed🙏🏻

I ordered for 1 year and put them in the freezer

nedim profile image
nedim in reply to delboy381

can you post where from did you order?

nedim profile image
nedim in reply to nedim

I found it in Serbia - it costs 25EUR , 30 packs.

beopanax.com/sr/proizvod/se...

delboy381 profile image
delboy381 in reply to nedim

That's it! They import from Italy. The factory for production in Italy is called Farcoderma.

Robb48 profile image
Robb48 in reply to delboy381

Curious thing re the French product - looking at the website for Bened, the company developing PS128, they have a world map showing location of manufacturing facilities, and also "Bened product markets" - France is not included in either. Hmm. Also I found an article from a couple of years ago with the headline "EU firm Beopanax selected as exclusive psychobiotic product distributor". But maybe this is out of date?!

So, struggling to find out how to get it to the UK now, without going with the French "Neurobiotique". I think I'll send a quick message to Bened asking on both issues.

glenandgerry profile image
glenandgerry in reply to Robb48

Same here, I'm in the UK and also struggling to find the best/cheapest way of getting 'Second Brain'

Robb48 profile image
Robb48 in reply to glenandgerry

I left a message for them on their site re both questions above, and the advisability of international postage given requirement for refrigeration - will post here their response when they get back to me.

glenandgerry profile image
glenandgerry in reply to Robb48

Awesome, thank you so much

Robb48 profile image
Robb48 in reply to glenandgerry

Reply copied from Bened:

"..we provided PS128 to Synergia for their product in the past. Currently, we are supplying the strain in the EU to Neuraxpharm (for product Neuraxbiotic Spectrum, sold in Spain, Portugal, Germany, Poland, Czech Republic, Slovakia, Austria, Hungary, Italy) and Beopanax (for product Second Brain, sold in Serbia, Kosovo, Bosnia, Montenegro, Macedonia, Croatia, Slovenia, and Albania).

Regarding shipping and efficacy, you're right that lack of temperature control can negatively affect a probiotic's potency. The PS128 strain should always be refrigerated when possible. We know that is not always practical during shipping, so each of the products listed above include enough overage (extra PS128 above the amount guaranteed for each dose) for at least that amount left at their expiration date - even considering some shipping time at room temperature. Especially now that outside temperatures are cooler, the CFU count should not be decreased by much before the order reaches you.

Unfortunately, there is not currently a distributor selling a product with PS128 in the UK. In the meantime, I can recommend a few different PS128-containing products:"

- They go on to recommend Solace (US) and Activhealth (Singapore) in addition to the above. I've now bought from the latter, with the special offer, close to use by date sachets. Also asking Bened to check that freezing is unwise (probably) and what the normal shelf life is, so I can see how quickly it degrades.

Robb48 profile image
Robb48 in reply to Robb48

Another reply from Bened:"Under normal refrigeration, PS128's shelf life is at least 2 years. Freezing the product is just fine. Feel free to store them that way if you'd like to keep them even longer."

Nice! So the almost expired products many here are buying can be chucked in the freezer to last for longer.

Love the customer service from these guys too.

Millbrook profile image
Millbrook in reply to Robb48

Thanks! I just ordered a whole years worth and put them in the freezer. At the clearance price it’s a steal.

delboy381 profile image
delboy381 in reply to Robb48

It’s not outdated because the date is good on the boxes. You need to send an email with an inquiry. At least it doesn't cost anything.

Did you email them? I thought we had to place the order online, no?

JeanieBeanie profile image
JeanieBeanie in reply to Robb48

Check OAFC's link above. Just ordered some.

Robb48 profile image
Robb48 in reply to JeanieBeanie

Looks interesting, and the price is good (had to look hard to see it is 30 sachets!), unfortunately they dont give a breakdown for the number of PS128 cells vs the two other cultures they have in the sachets. Although PS128 is listed first on the ingredients, so I guess the minimum is 1/3rd. Give the low price I guess just take more :).

Buckholt profile image
Buckholt in reply to Robb48

This is widely available in mainland Europe, but waiting to find out if there’s a UK distributor.As I understand it is, Neuraxpharm are the European Licence holder

.
Robb48 profile image
Robb48 in reply to JeanieBeanie

Damn, didnt see they have two products, including MIND rather than ACTIV. The former is only PS128, I just ordered the latter, oops.

Millbrook profile image
Millbrook in reply to Robb48

ACTIVE is the one recommended for PD

JayPwP profile image
JayPwP in reply to Millbrook

It seems the only recommendation for PD is PS128

Millbrook profile image
Millbrook in reply to JayPwP

My husband is taking the ACTIVE formulation which has PS 128 (30 billion) and K21.

JayPwP profile image
JayPwP in reply to Millbrook

Millbrook,

The ACTIV contains PS128 + K21, both combined totalling 30 billion CFU.

MIND contains only PS128 totalling 30 billion CFU.

The research does not emphasize K21 strain, only talks about PS128.

Maybe the combination is better, but nothing is documented in favour of the combination.

Despe profile image
Despe in reply to JayPwP

I was wondering if K21 is same as Bio-Kult's PXN 21.

JayPwP profile image
JayPwP in reply to Despe

Maybe. Here's the response from Bened:Hello Jay,

I'm glad to receive your email. We are currently working with a distributor in India, and the product is nearing the registration stage. However, that process is likely to take several months before the product is available for purchase from India. I will be sure to let you know when that happens.

In the meantime, Activhealth in Singapore (Multibiotics | Activhealth | Healthy Mind, Healthy Body) and Solace in the US (SOLACE – Solace Probiotic) may be able to ship internationally. Please contact them directly for specific product information or to purchase.

Robb48 profile image
Robb48 in reply to Millbrook

Curious why you think the Active is recommended for PD, did you ask one of the companies for advice? I've sent a quick message to see if my order can be amended to some of both, so I can try each on my Mum when they arrive (has MSA)

Millbrook profile image
Millbrook in reply to Robb48

Yes I spoke to them and when I mentioned PD they said ACTIVE was the one I should order. I had initially ordered MIND but changed to ACTIVE after speaking to them.

So my husband has been on it since june. It has been about 4.5 months

I did speak to them about K21 and what it was supposed to do. She mentioned reducing inflammation and lipids. I was too happy that I could get the product, made in Taiwan right here. And since she said her PD clients took ACTIVE I ordered it. They also have other probiotics for autism , depression etc

Robb48 profile image
Robb48 in reply to Millbrook

Oh interesting, thanks for the reply!

JayPwP profile image
JayPwP in reply to Millbrook

The ActiveHealth website recommends the combination PS128 + K21 for Neurological disorders

activhealth.com.sg/multibio...

glenandgerry profile image
glenandgerry in reply to nedim

I emailed them - they replied saying they are unable to supply the UK

Millbrook profile image
Millbrook in reply to park_bear

PB look at OAFC ‘s post on the PS 128 that my husband is taking. It’s on special about £5 a box. You have to pay for shipping but you can order the max amount that yr shipping costs allows. The website is wellbeingsg.com

Despe profile image
Despe in reply to Millbrook

Millbrook,

Last week I received my second order of Solace (3 boxes) which is very expensive. Thanks to you and OAFC, I will start ordering the one you have been using on your husband. I bookmarked the site. Thanks!

Millbrook profile image
Millbrook in reply to Despe

Hi Tina,

I think that the product can still be consumed one or two months after expiry date. It’s essentially powder form and as long as it is stored properly should be fine.

That’s just my opinion.

It’s amazing the delboy381 only takes 1 sachet and has got such good results. The clinical trial used 2 sachets at bedtime.

Wishing you the same miraculous results .

Buckholt profile image
Buckholt in reply to Millbrook

Best before shown as 18 Dec 2021 so only one month in date once received.

delboy,

Forum member Millbrook reported very good results in her husband using PS-128 over a relatively short period of time also!

Art

delboy381 profile image
delboy381 in reply to chartist

I glad to hear that. I don’t want to claim anything about this probiotic, but so far for the first time I feel like something from the supplements is helping me. It boosted my self-confidence. My opinion is that the end of this unhealthiness is getting closer. One part of Michael's interview I recently read:

With the Foundation, which has raised over $1 billion to date for Parkinson's research, "we are loading up all the cannons we can and pointing them at the target," Fox told PEOPLE earlier this week. "One of them will fire and it will happen. The disease is a problem that will be there until you solve it. But we're hopeful."

Hi Delboy,

I wrote a post on PS 128 in June 2021. Within 2 weeks there was 180 degree turnaround affecting balance, stiffness, slowness, driving. Everything was normalised. It was a miracle. My husband takes 2 sachets -60 billion- at bedtime.

He took the probiotic at the same time as doing the coronet duo 2x a day so now we are committed to both.

I am so happy for you that PS 128 accomplished as much as it did for us.

My husband has been taking it since June and continues to take it daily and the improvements have been sustained. You can click on my icon and read my post on PS 128. Like you I was so excited and happy about the improvements I could not wait to share with my friends here on HU so that they too could experience the same benefits.

delboy381 profile image
delboy381 in reply to Millbrook

Hi Millbrook.

I'm glad to hear that. Believe me, I felt the effect after the second day. I use one sachet and take it before lunch, mixing it with water for half an hour. Like I told Art, it boosted my confidence. Time will tell. I wish you all the best. Oh, can you put where you buy ps128?

Millbrook profile image
Millbrook in reply to delboy381

I live in Asia and got the contact from Benemed itself. They Mail mainly to NZ, Australia n Asia.

The website is wellbeingsg.com

The brand is ACTIV health multibiotics containing PS 128 and K21.

This contact was given to me by Benedbiomed.

They had a one for one promotion to clear stocks that were expiring Dec 2021. Price is S$45 for box of 30 so you need 2 boxes for a month.

I am very glad that you have experienced the same great results.

Thank you for validating my post.

delboy381 profile image
delboy381 in reply to Millbrook

I suggest members who live in the USA who are interested in this product contact directly at benedbiomed.com/ to see how to order for the USA.

rebtar profile image
rebtar in reply to delboy381

I just ordered from the Singapore website mentioned above. No problem. Including shipping costs $141 to US for four boxes.

delboy381 profile image
delboy381 in reply to rebtar

Good. I hope you will have benefits.

rebtar profile image
rebtar in reply to delboy381

I hope shipping from Singapore is done in a way that the product isn't damaged in shipment. Many but not all probiotics are very sensitive to temperature.

delboy381 profile image
delboy381 in reply to rebtar

I really don’t know, I have no experience with that kind of order and shipping. It's going to be alright.

Millbrook profile image
Millbrook in reply to rebtar

According to the supplier the product is not affected by temperature unless it is very hot but best to store it in cool and dry place once you receive it.

That seems surprising. All lactobacillus are sensitive to temperature and deteriorate quite quickly. You can probably test viability by making a yoghurt from a sachet. Don't worry what it tastes like, as long as it ferments into yoghurt

Personally I store mine in the fridge though I was told it was not necessary as long as it was a cool place. Heat is more of a problem here. I will try making yoghurt with it and let you know.

Millbrook profile image
Millbrook in reply to Millbrook

Yay!!! The yoghurt formed was beautiful and tasty.

If only I could know how many billion in it

Hi WTP,

I made a yoghurt with one sachet of PS128+K21. After some of you mentioned temperature concerns ( nowhere is hotter than being on the equator) I did it to placate my own fears that all the live probiotic were dead.

So happy to report yoghurt taste really nice and pleasant- not sour

and very palatable .

lionessroar profile image
lionessroar in reply to rebtar

Have you actually received your order? I placed an order from the Singapore site 12 days ago and just received this message "... the parcel has just been rejected by the US customs due to some unforeseen circumstances." 😔

rebtar profile image
rebtar in reply to lionessroar

I received my first order. I placed a second order and have not received it or a message like yours. I messaged them through their website, waiting for a reply.

I placed an order over a month ago & it was also refused at customs, then returned to Singapore. Because of these refusals they are no longer shipping to the US.

Redginger profile image
Redginger in reply to Millbrook

Why should we get the one with K21 added? I dont see that it says anything about buy one get one.

Millbrook profile image
Millbrook in reply to Redginger

Hi Redginger,You can buy which ever one appeals to you. There is no compulsion here.

Redginger profile image
Redginger in reply to Millbrook

Yes, I realize. I just wondered why that one was preferred. I read more this morning and did choose that one. After such connection trouble last night I tried again this morning and finally was able to complete order. There was no 1 for 1 that I could find but I was able to get a good deal, I thought. Just now hoping for survival in the shipment. Thank you for your contributions to this group, Millbrook.

Millbrook profile image
Millbrook in reply to delboy381

Wow. It worked for you on only 1 sachet? Awesome🙌

I notice that with the French sourced version, they suggest storage at between 4 and 7 degrees, preferably in the refrigerator. Seems precise and I wonder if this applies to other versions? Would international shipping affect the efficacy, as storage temperature would be out of control?

synergiashop.com/en/neurobi...

Fed1000 profile image
Fed1000 in reply to Buckholt

I used the French version for a while. They use special packaging for sending. it shouldn't deteriorate.

Farooqji profile image
Farooqji in reply to Buckholt

Yes definitely the conditions during shipping Will affect the efficiency. I had contacted the main manufacturer a few months back and his reply was as under"I’m glad to receive your email. Currently, we do not have a distributor that covers your country. PS128 is a delicate probiotic that is best kept refrigerated and shipped via cold chain, and logistically, that is quite difficult in your country. Our Singapore distributor, Multibiotics | Activhealth | Healthy Mind, Healthy Body, may be an option. Please contact them directly and see.

If there is anything else I can help with, please let me know.

Only the best,

Sam Noble

Int'l Dept. Product Manager, Bened Biomedical

mob: +886-9-7831-4917 | tel: +886-2-2511-1122

benedbiomed.com"

Millbrook profile image
Millbrook in reply to Farooqji

The website for ACTIV health is wellbeingsg.com

Sorry, I have a different experience. I take PS128 already 2 months - 60 billions daily. There are no improvement of none of my symptoms. My PD was diagnosed two years ago. This is NeuraBiotic Spectrum produced by Bened Biomedical Co.Ltd in Italy.

delboy381 profile image
delboy381 in reply to Robert3

Hi Robert.

I have emphasized that we are not all the same and that it may not have the same effect in another, similar to B1. It is not my intention to give false hope to anyone.

We are in a position to look for what will make our life easier and better. All the best.

Millbrook profile image
Millbrook in reply to Robert3

Sorry to hear that Robert. Perhaps you may want to try the coronet Duo that other members are using as well. My husband used coronet duo and PS128 simultaneously. I was inclined to think that the change was due to PS 128 because red light takes time to be effective.

We are not promoting any product and have nothing to gain from it other than helping others get better.

In the clinical trial that ran for 12 weeks 70% of participants experienced improvements and 20 % of the 70% experienced great improvements.

It is worth trying for everyone. It does not cost an arm and a leg at the clearance price and it could very well change your life.

It was life changing for me. Previously I could not leave my husband alone for fear of falls. Now his balance is normal and he can function independently. He is more alert and functions normally in everything. The slowness is gone. It’s a miracle 😭

Where do you get the probiotic from, is it reliable on delivery?

It could be beneficial.I don't have PD I have Parkinsonisms and I've been taking it for 6 weeks with a lot of other supplements. Had some minor tremor improvements hard to say because of what. But I have stopped now because recently I am experiencing some dizziness (don't know the reason yet) and I'm on regular probiotics.

My probiotics say it contains lactobacillus plantarum (LP-115). Can anyone explain the difference? Thx.

Millbrook profile image
Millbrook in reply to RBan

Plantarum has different strains. This is specifically PS 128 in the plantarum family. So all the other strains are different.

RBan profile image
RBan in reply to Millbrook

So this means the other strains aren’t effective?

Millbrook profile image
Millbrook in reply to RBan

Essentially the clinical trials used PS128 to get those results. Taking other strains have no proven track

Also the dose is 60 billion which is 2 sachets daily - 2 boxes a month

However delboy381 only took 1 a day to get results. But Faridaro who took 1 a day had no results

RBan profile image
RBan in reply to Millbrook

Thx Millbrook!

Millbrook profile image
Millbrook in reply to RBan

If you want to try PS 128 now would be a good time as they are clearing stocks that are due to expire Dec 2021. This is the one that my husband is taking. It works out to about £5 for a box of 30 sachets excluding shipping. Best to order maximum amount that the standard shipping allows.

The website is wellbeingsg.com

You would need 2 boxes a month as the clinical trial used 60 billion at bedtime for 12 weeks.

Wishing you all the best

I know these were likely posted in previous PS128 threads, but it is relevant and worth posting again :

ncbi.nlm.nih.gov/labs/pmc/a...

ncbi.nlm.nih.gov/labs/pmc/a...

ncbi.nlm.nih.gov/labs/pmc/a...

pubmed.ncbi.nlm.nih.gov/343...

ncbi.nlm.nih.gov/labs/pmc/a...

ncbi.nlm.nih.gov/labs/pmc/a...

ncbi.nlm.nih.gov/labs/pmc/a...

sciencedirect.com/science/a...

And the US does not make this product because.....?

Art

Millbrook profile image
Millbrook in reply to chartist

Thank you Art- our trusty resource library

Sydney75 profile image
Sydney75 in reply to chartist

Thanks!

I already take Lactiplantibacillus (Lactobacillus) plantarum as a probiotic supplement by SWANSON:

swansonvitamins.com/swanson...

For all I know, the very inexpensive Swanson L. Plantarum supplement might be partially comprised of the PS 128 strain. In fact, it might even be entirely comprised of PS 128. The label simply does not specify which substrain of L. Plantarum is in the bottle.

And dog food made from "meat & animal derivatives" might be made from lean fillet steak.

Probably it isn't

If it was made from lean fillet steak pet food labelling laws permit the manufacturer to say so

And guess what?

This is not an endorsement but I was just clued in to this one: Thryve Inside Mood Enhance Probiotic

amazon.com/dp/B089MBWQRS/re...

Ingredients

"Probiotic Strains : Proprietary Probiotic Blend 500mg Lactobacillus plantarum PS128™ +5 billion, 5 billion Lactobacillus paracasei PS23™, Mix7 (St. thermophilus Z57, Lb. delbrueckii ssp. Bulgaricus LB2, Lb. acidophilus LA1, Lb. plantarum 14D, Lb. paracasei 101/37, Bf. breve Bbr8, Bf. breve BL10, Bf. animalis ssp. lactis Bi1) "

Hi Bolt. The PS 128 is30 billion in one sachet

Yes. This one you get 5 billion but it only costs $30 for 30 capsules.

JAS9 profile image
JAS9 in reply to Bolt_Upright

Yes, I saw this too. So, you'd take 12 capsules a day?

Cost is about $12/day or about $360/mo!

What if I bought one month's supply of Solace then used some of that to ferment my own PS128? (Instructions on how to make your own probiotics are easily found on the internet.) According to Solace's website, they use fermented mustard greens. The only problem is dosing, but is that really a problem? After all, we're talking about swallowing fermented food (that is quite safe; fermented foods have been around a long time and are generally health-promoting). These fermented foods already have, by definition, bacteria that caused the fermentation. If I'm careful and introduce PS128 into the process I should be able to consume at least a small amount of the fermented mustard greens without any problems. If I get too much of it, my gut might make even more dopamine than somebody getting "just" 60bln CFUs. That wouldn't be terrible. Am I wrong?

It will be interesting to see a longer term report. "Next day" improvements are usually placebo effect, but not always.

"The trials" are far from conclusive (human PD trials - not immodium induced mouse constipation trials)

NCT04722211 - a proper trial, listed Jan 21, 120 participant placebo controlled , still recruiting, due to report end next year

PMC8277995 - open label, 25 participant 12 week duration 2021. Interesting, but needs a trial like NCT04722211 to corroborate

NCT04389762 open label 120 participant 12 week duration COMPLETED June 2020 - no results posted. No results posted 15 months later usually = "didn't work"

NCT03566589 2018 trial - no results posted

The trials are all of PS128 - not the cocktail with K21. So 60 billion cfu of a reputable sourced PS128 - like Synergia Neurobiotique, if kept cool in transit and storage, should be equivalent to the trial.

Forum feedback on this thread seems to be pretty evenly split between "didn't work for me" and "great results"

As I said at the start, it will be interesting to see the results 6 months out

Cant find any availability in India. Have written to wellbeingsg and bened as well. Let's see

Millbrook profile image
Millbrook in reply to JayPwP

You can order it on wellbeingsg.com or WhatsApp them on +65 88629039 with your questions

Product is made in Taiwan

JayPwP profile image
JayPwP in reply to Millbrook

Thanks

JayPwP profile image
JayPwP in reply to Millbrook

And they say they don't deliver to India. Also they are out of stock due to the December expiry.

I understand that a licence has been granted in Europe to Neuraxpharm, to distribute PS128 . The Neurorax Biotic Spectrum product looks widely available in continental Europe, but not UK. I have emailed the company to see if there is a UK supplier.

.

I used to make wines with a group of friends and we started by using prepacked yeast variety's . being slow learners it took about 15 years to smarten up and use a yeast that mother nature developed rather than just any old 'YEAST' and we started to have superbly flavour and body, etc.

Think of that statement about bunch of grapes down in the far corner of the Vinyard that is harvested yearly and has superb flavour and body. far better than the rest of the variety adjacent.

Now, what is one of the factors that is missing from this discussion of a very finely (?rare) refined yeast? (PS218)

If you give up here is the answer: There has been NO discussion of the foods or style of meals/foods ie Vegan, Meat-a-terian, etc.

The inclusion of that information would help others reading "It worked for me" if there is a reasonable chance of success.

Just saying....

What's best time of day to try prebiotic? Don't want stomach upset, with or without food?

delboy381 profile image
delboy381 in reply to Sydney75

Hi, I use one sachet half an hour before lunch. Honestly I have stomach pain sometimes and I guess that’s normal because there’s a little war going on in the gut flora. A member Millbrook her husband used in the way described in the study, at bed time. I said time will tell how effective this probiotic is.

I just made a batch of yoghurt from 1 sachet of PS128 +K21. So they are alive! Maybe you may want to try. Only thing is you will not know how many billion in it and how much to consume to get 60 billion dose

I purchased some from Solace in the summer. The first shipment arrived hot (literally hot to touch) and I asked for a replacement. The next batch was a bit warm, but not as bad.

Customer Service said -

"In regards to your concern about Solace being exposed to heat, there was a study conducted examining this very question. When tested at 77 degrees Fahrenheit (5 degrees above room temperature) for 30 days, 75% of the probiotics survived. When tested at 99 degrees Fahrenheit, for 15 days 50% of the probiotics survived."

I tried one and got a definite effect a few hours later - a flare up of lower back and urogenital pain. Same as what happens if I take Lion's Mane.

So it isn't for me, but FWIW my experience was that even after getting hot it did appear to be active and it did something. I can't speak to PD symptoms since I don't have PD.

BDNF is implicated in chronic pain: nature.com/articles/s41598-...

I should add that I eat tons and tons of fiber, so plenty for little beasties to feed on and do their thing.

Just in case one wonders where to buy:

The strain was isolated and patented by Professor Tsai Ying-Chieh[13] (National Yang-Ming University) and sold as a supplement ingredient by the company he founded, Bened Biomedical.[14]

In Europe, CNS pharmaceutical company Neuraxpharm, markets a product for autism containing PS128.[15] Synergia sells in the probiotic in France.

Solace and Thryve are brands containing PS128 in North America.

In Malaysia, Nuvanta sells a PS128 product.[16]

In 2020, Blackmores, an Australian health supplements company, announced plans to develop a PS128 product for the Australia/New Zealand market.[17]

How many sachets is the 1.5 grams and did you take that before every meal?

Millbrook profile image
Millbrook in reply to OAFC

Each sachet has 30 billion. According to the clinical trial 60 billion -2 sachets- is consumed at bedtime.

rebtar profile image
rebtar in reply to Millbrook

In water or dry?

Despe profile image
Despe in reply to rebtar

I received my order yesterday. Instructions are on the outside of the box.

Millbrook profile image
Millbrook in reply to rebtar

Either is fine but my husband just pours sachet into his mouth and eats it like that.

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