FYI - interesting stuff.
(there are numerous articles on the internet)
Neuroprotective properties of dietary saffron: more than just a chemical scavenger?
ncbi.nlm.nih.gov/pmc/articl...
Neuroprotective Potency of Saffron Against Neuropsychiatric Diseases, Neurodegenerative Diseases, and Other Brain Disorders: From Bench to Bedside
frontiersin.org/articles/10...
Saffron ameliorated motor symptoms, short life span and retinal degeneration in Parkinson’s disease fly models
John,
It is a common gourmet spice in Greece which I have been using it for years, sprinkling it on lots of foods I cook. This is what I regularly use. I had found a capsule, too, and I ordered it, but it was unavailable. 
amazon.com/Krokos-Kozanis-O...
Wow! I thought the Costco saffron was a good deal, but this looks much better.
Highly recommend it! I am also familiar with the source and its excellent reputation.
Looks good.
Here is another one, with Crocin, Safranal and Picrocrocin units listed. Costly though.
In Italy there is a product that they guarantee contains the chemical principles mentioned but it is also expensive. It is called Zaffit.
onlinelibrary.wiley.com/doi...
ConclusionsIn conclusion, thefindings of this study support previouswork (Purushothumanet al.2013) showing that pre-conditioning with dietary saffron can mitigate MPTP-induced parkinsonian neuropathology, and provide clues tothe molecular mechanisms underlying this protective effect.Further studies are now required to more precisely determinethe optimal saffron dosage for eliciting neuroprotection andassess the efficacy of commencing treatment after diseaseonset (i.e. post-conditioning). Nonetheless, the presentfindings are encouraging for patients given that saffronconsumption is an intervention that is safe, free from sideeffects at therapeutic doses, non-invasive, and easily admin-istered. Further exploration and understanding of the mech-anisms underlying saffron’s broad protective effects shouldhelp dispel skepticism around its use as a prophylactic (andpossibly therapeutic) intervention for neurodegenerativedisease.
researchgate.net/publicatio...
Neuroprotective effect of crocin against rotenone-induced Parkinson's disease in rats: Interplay between PI3K/Akt/mTOR signaling pathway and enhanced expression of miRNA-7 and miRNA-221
In conclusion, crocin showed promising neuroprotective effects in ROT-induced PD via activation of PI3K/Akt/mTOR axis and enhanced miRNA-7 and miRNA-221.
Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials 2013
pubmed.ncbi.nlm.nih.gov/242...
Conclusion: Findings from clinical trials conducted to date indicate that saffron supplementation can improve symptoms of depression in adults with MDD. Larger clinical trials, conducted by research teams outside of Iran, with long-term follow-ups are needed before firm conclusions can be made regarding saffron's efficacy and safety for treating depressive symptoms.
Conflict of interest statement
6 Competing interests
Drs. Anton and Hausenblas serve as scientific advisors and as consultants for the company ReBody, LLC, which is an affiliate of Reserve Life Organics., LLC d/b/a Reserveage Organics, the developer and marketer of a product in which saffron is used. Neither author has received personal financial gain from sales of this product. All findings and views expressed in this paper are those of the authors and do not necessarily reflect the views of the Reserve Life Organics, LLC, d/b/a Reserveage Organics that funded this trial.
A Systematic Review of Randomized Controlled Trials Examining the Effectiveness of Saffron (Crocus sativus L.) on Psychological and Behavioral Outcomes 2015
Predication of the Underlying Protective Effect of Saffron on Parkinson's Disease via Network Pharmacology and Molecular Docking assets.researchsquare.com/f...
Conclusion
Saffron exhibits a synergistic effect via multiple targets and pathways in the treatment of Parkinson's disease and our systemic pharmacological analysis provides a basis for the clinical application and in-depth study of saffron.
Thank you for posting this John!
It appears that Saffron also increases short chain fatty acids (SCFAs) and alters the gut microbiome (mice) in a positive way, something that PwP have a shortage of and it also has the desirable anti oxidative stress effects as well as antiinflammatory effects! These are all useful characteristics in an anti PD supplement. These are effects that would be quite handy for C/L to have to offset the oxidative stress that C/L causes, but is lacking. Saffron also has the positive effect of improving the gut mucosal barrier. These are similar to some of the effects of FMT.
ncbi.nlm.nih.gov/pmc/articl...
Here is a link to a typical Saffron Extract supplement on Amazon :
amazon.com/Capsules-Supplem...
I would have to read more to get a better idea on dosing, but if you had to take one a day the cost would be $.30 cents/day and if you had to take two per day it would be double or $.60 cents/day plus shipping and tax.
Art
I would prefer to take the actual Saffron instead of any supplement.
Here is another one that seems to be good. (From Spain)
This new RCT shows that low doses of Saffron improve sleep and increase melatonin levels. Well, this is getting more interesting!
pubmed.ncbi.nlm.nih.gov/344...
Art
Inositol hexaphosphate: A natural iron chelator that may protect dopamine neurons
Memory, Cognitive Decline, AD, PD & Dementia And A Potential Way To Help Deal With Them Using "LO"
Has anyone heard about this doctor and his treatment for PD among other diseases.
Stem Cell Success With MSTrehalose as a promising therapeutic candidate for the treatment of Parkinson's disease - 2019
