Do You Like To Read? Oxidative Stress in Parkinson’s Disease: Potential Benefits of Antioxidant Supplementation

[Bolt_Upright]

This has a LONG LIST of things we have tried and considered, with annotations on effectiveness. Very interesting.

hindawi.com/journals/omcl/2...

[Bolt_Upright]

I found it searching acetyl-L-carnitine and alpha lipoic acid. I heard these might be good together.

[Smittybear7 in reply to Bolt_Upright]

They are good together..

[wriga]

I'm pretty much in ageeement with this paper and there are many other similair ones. But I don't think that you can resolve oxidative stress and mitochondrial dysfunction with natural antioxidant molecules in diet although you may be able to prevent it if you start early in life .

They correctly mention melatonin but seem to have omitted sulforaphane among the sulfur molecules which is a bit odd given the wealth of information on that.

[laglag in reply to wriga]

wriga, are you still taking the sulforaphane?

[wriga in reply to laglag]

Yes, 20 months of experimentation now and still learning.

[Bolt_Upright in reply to wriga]

Hello wriga, where do you come down on the store bought sulforophane? Do you think it is helpful? Any brand recommendations? Thanks.

[carpark in reply to wriga]

3.6.3. Sulforaphane

It is an organic isothiocyanate extracted from many cruciferous vegetables, such as cabbages and broccolis. Bao et al. [261] investigated its effect on MPTP-induced damage in PC12 cells, reporting its ability to reduce Nrf2, HO-1, and nicotinamide quinine oxidoreductase, concluding that sulforaphane protected the cells via activation of the Nrf2-antioxidant responsive element pathway.

[Smittybear7 in reply to carpark]

I'm low in Sulfur would this help?

[Bolt_Upright in reply to Smittybear7]

Sulforaphane and sulfur are two different things. You should join the weekend Zoom calls. We discuss these things. us02web.zoom.us/j/833522248...

Saturdays, 7 PM – 8 PM-ish, US Central Daylight Time (GMT–6.)

Sundays, 11 am – 12 PM-ish, US CDT.

[JayPwP]

Nevertheless, it is worth noting that free radicals exert several beneficial roles in mammalian cells, such as ATP production, phagocytosis, and cell signaling [82], and the indiscriminate use of antioxidants might be harmful.

[Gioc]

Interesting summary, but as often happens, there is no adequate evaluation of the data with respect to what we are trying to accomplish, that is, a slowing down of Parkinson's disease. So all of these substances look the same like drops of water but this is not the case. As noted by Wriga some recent research is very underestimated, however I find it a very interesting study, thank you for sharing it.

[LAJ12345]

So hopefully eating a varied diet with as many plants (vegetables, fruits, nuts, seeds, herbs, spices) as you can find will give you a chance of stumbling across the magical combination of these ingredients which together have a synergistic effect?

[Smittybear7]

Trying to find a doctor who can tell you the right amount of the antioxidants to take is very difficult. I take a lot of antioxidants in hopes of slowing down the progression. Appreciate any information you may have. This is safe to take melatonin? Do you need a prescription for that? Thanks for your help