Opicapone is used once daily as adjunctive to levodopa/carbidopa to reduce “off” periods in patients with Parkinson’s disease.
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In clinical trials BIPARK I and II, 50 mg of opicapone once daily was shown to be noninferior to entacapone and reduced the mean off time by about 50 min when compared to placebo.
I started treatment with opicapone over a month ago. While it's early yet, I have seen no improvement.
Next-generation gloves for vibrotectal coordinated reset -- wishlist
COMPT inhibitors friend or foe?
Third dose of levodopa on the day generally fails to work. 
“If Who is on First, What is on Second; No, He is on Third” (TTFD, Allithiamine, Fursultiamine)
Urolithin-A - has anyone looked into this to trigger mitophagy (and thereby generate new mitochondria)?
