Experiences with

Opicapone

https://www.medscape.com/viewarticle/opicapone-early-parkinsons-time-revisit-label-comt-use-2024a1000im9?form=fpf

They have now suggested taking Opicapone 50mg but I’ve read bad things about this and she’s previously had another tablet at night increasing something that didn’t agree with her and made her light headed, so I just don’t think this is the solution but I wanted to know other peoples experiences.

I was wondering if people who have taken Opicapone have been given any instructions on how to scale down the amount of levodopa they take per day. I would be grateful if you share this information here. Thank you in advance.

About a month ago I was prescribed Opicapone 50 mg which I took under medical supervision.

hello everyone, What ‘s the best time to take opicapone, early morning or late pm ? I actually take madopar 125 mg at 08am /11am / 2pm / 5pm / 8pm / 11pm / 3am Thanks Marc

It's not painful enough to be a UTI, but the only medication that HAS given me a UTI in the past was Opicapone (just one amongst a suite of problems that it caused), so I'm kind of eyeing the Stalevo and it's Entacapone content with suspicion as they are both COMT inhibitors.

For those who are taking Opicapone, how many days it needs for it to start to work? I started 2 nights ago at 11pm after 400 mg di Sinemet during the day, but it is like to eat a candy: nothing happens 🫥

Hello all, I have been experiencing off times about 3 1/2 hours after taking one C/L, so my MDS suggested one of these three medications as an add on. (I started with Nourianz, which had no effect. I’m wondering about what people’s experiences has been with any of these drugs? Pros and cons? Thanks

I ran into opicapone, a.k.a. Ongentys, and it seemed to sound like a better option than Entacapone, so I ordered a three month supply of it. I’m now two months on Ongentys, and it’s no more effective than Entacapone.

- Once-daily opicapone 50 mg with carbidopa/levodopa helped achieve and maintain plasma concentrations of levodopa in patients with PD.- Maximum COMT inhibition was nearly 85% at day 14. - Adding once-daily opicapone 50 mg to carbidopa/levodopa therapy helped achieve and maintain plasma concentrations

These days my doctors have prescribed me opicapone in combination with levodopa. I currently take 600mg of Sinemet, 10mg of selegiline and 3 grams of Vitamin B1 per day. I wanted to ask who takes opicapone their experience in this regard.

does anyone have any news views or opinions on these drugs ?

I recently saw my neurologist & he wants to put me on Opicapone, as my off times are getting longer, however I would rather like to give the B1 therapy another go before trying this new medication. This time with magnesium & B complex.

https://www.youtube.com/watch?v=LA6CdWs6Y1w

https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-022-02602-8 more on OpiCapone https://www.youtube.com/watch?v=S7gqfynW-wI

Opicapone is used once daily as adjunctive to levodopa/carbidopa to reduce “off” periods in patients with Parkinson’s disease.

Can Opicapone be taken in the morning instead of the evening? This would be more useful as it's effectiveness does not last for 24 hours.

I'm being prescribed a COMT inhibitor Opicapone to try and extend my 'on time'. I was wondering if anyone uses this already and has it worked for them? 🤔

I have tried amantadine , opicapone and entacapone but they have all made my symptoms worse. The future looks bleak unless can find a way to extend the on time. Do people find that food has a major part to play in there ons.

My husband was given Opicapone about 18 months ago but stopped taking it for some reason. He started taking it again just over a month ago. He found immediate improvement with it eg. not having to go to the toilet so often during the night but he is finding it difficult to get the correct dose.