Damage to upper GI tract lining tied to 7... - Cure Parkinson's

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Damage to upper GI tract lining tied to 76% higher Parkinson’s risk

jeffreyn profile image
7 Replies

"One possibility is that mucosal damage in the upper GI tract — the esophagus, stomach, and first part of the small intestine — could trigger inflammation in the gut that spurs the disease."

PNT article: parkinsonsnewstoday.com/new...

Research paper: Upper Gastrointestinal Mucosal Damage and Subsequent Risk of Parkinson Disease.

jamanetwork.com/journals/ja...

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jeffreyn profile image
jeffreyn
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7 Replies
JayPwP profile image
JayPwP

More and more clues are pointing to the gut...

Bracondale profile image
Bracondale in reply toJayPwP

I'm getting the strong impression that the vast majority of chronic illnesses are connected with gut problems.....dysbiosis and resultant local and systemic inflammation.

Eryl profile image
Eryl

And wha's causing this damage? I would highly suspect gluten and artificial emulsifiers found in processed foods.

Likii profile image
Likii

Interesting. Here's a similar v. good post - including your reply - from 7 years ago:

healthunlocked.com/cure-par...

jeffreyn profile image
jeffreyn in reply toLikii

I would say that the old post is complementary, rather than similar. Its focus is on one (central) link in the chain. There is also a good AlzForum article covering the Stolzenberg et al. research paper:

Put ’Em Up: Does α-Synuclein Help Fight Microbes in the Gut?

alzforum.org/news/research-...

Likii profile image
Likii

So what are the antidotes? I.e. What works?

jeffreyn profile image
jeffreyn in reply toLikii

From the research paper (jamanetwork):

"These findings likely suggest 1 of 2 possibilities: first, that [mucosal damage] may serve as an inciting event that could precipitate pathologic alpha-synuclein misfolding in the gut. Second, as dopamine is known to play a key gastroprotective role, it may be that patients with subclinical dopaminergic signaling reduction are at higher risk of [mucosal damage] and that alpha-synuclein pathology preceded this event."

I haven't yet given up on buntanetap.

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