"One possibility is that mucosal damage in the upper GI tract — the esophagus, stomach, and first part of the small intestine — could trigger inflammation in the gut that spurs the disease."
PNT article: parkinsonsnewstoday.com/new...
Research paper: Upper Gastrointestinal Mucosal Damage and Subsequent Risk of Parkinson Disease.
More and more clues are pointing to the gut...
I'm getting the strong impression that the vast majority of chronic illnesses are connected with gut problems.....dysbiosis and resultant local and systemic inflammation.
And wha's causing this damage? I would highly suspect gluten and artificial emulsifiers found in processed foods.
Interesting. Here's a similar v. good post - including your reply - from 7 years ago:
healthunlocked.com/cure-par...
I would say that the old post is complementary, rather than similar. Its focus is on one (central) link in the chain. There is also a good AlzForum article covering the Stolzenberg et al. research paper:
Put ’Em Up: Does α-Synuclein Help Fight Microbes in the Gut?
So what are the antidotes? I.e. What works?
From the research paper (jamanetwork):
"These findings likely suggest 1 of 2 possibilities: first, that [mucosal damage] may serve as an inciting event that could precipitate pathologic alpha-synuclein misfolding in the gut. Second, as dopamine is known to play a key gastroprotective role, it may be that patients with subclinical dopaminergic signaling reduction are at higher risk of [mucosal damage] and that alpha-synuclein pathology preceded this event."
I haven't yet given up on buntanetap.
APOE4: Risk factor for Alzheimer’s disease breaks the blood–brain barrier.
