Tetracycline Antibiotics may benefit Parkinson's disease

[JayPwP]

1. ncbi.nlm.nih.gov/pmc/articl...

Minocycline, a semisynthetic tetracycline-derived antibiotic, has been shown to exert anti-apoptotic, anti-inflammatory, and antioxidant effects. Furthermore, there is rapidly growing evidence suggesting that minocycline may have some neuroprotective activity in various experimental models such as cerebral ischemia, traumatic brain injury, amyotrophic lateral sclerosis, Parkinson’s disease (PD), Huntington’s disease, and multiple sclerosis. In this perspective review, we summarize the preclinical and clinical findings suggesting the neuroprotective role of minocycline in PD.

2. parkinsonsnewstoday.com/201...

Brazilian researchers discovered doxycycline’s ability to prevent Parkinson’s symptoms when mice were mistakenly fed chow containing the antibiotic. Thirty-eight of 40 mice that had been programmed to develop Parkinson’s disease for research purposes showed no symptoms after eating doxycycline-laced food.

[JayPwP]

One thought which comes to mind is these antibiotics will destroy gut flora, while exerting beneficial affects on neurons, therefore a good quality pre-pro-biotic is necessary.

Also need to check impact on kidneys.

[alaynedellow]

I'm allergic to tetracycline. Sod's law. 🤪

[kaypeeoh]

This was discussed last year. I feel like the Old Guard. I Had Doxycycline 100mg on the shelf in my veterinary practice. I put myself on one tab BID but quit after two weeks. I'd forgotten that tetracyclines can react with sunlight to cause a rash. Didn't affect my tremor anyway.

[JayPwP in reply to kaypeeoh]

Thanks. You dont look old at all.