Phenylbutyrate for Alpha-synuclein Cleara... - Cure Parkinson's

Cure Parkinson's

27,436 members28,803 posts

Phenylbutyrate for Alpha-synuclein Clearance from the Brain

JayPwP profile image
8 Replies

michaeljfox.org/grant/pheny...

Objective/Rationale:

In our previous research, we have discovered that a drug called phenylbutyrate can turn on a protective gene in the brain and can prevent Parkinson’s disease (PD) in models that are genetically programmed to get the disease. The drug works by transferring abnormal proteins from brain cells into the bloodstream. We now want to see if the drug works in patients with Parkinson’s in the same way. If it does, the drug may be able to stop the progression of Parkinson’s disease.

Written by
JayPwP profile image
JayPwP
To view profiles and participate in discussions please or .
Read more about...
8 Replies

That was from 2013If anything positive came of it we would know by now

JayPwP profile image
JayPwP in reply to

Or it was not patentable, and therefore not investable

😆😆

Bolt_Upright profile image
Bolt_Upright

What the heck? 8 years and not even a failed trial?

Bolt_Upright profile image
Bolt_Upright

It looks like they mixed it with something else and relabeled it AMX0035 but only seem to be testing it on ALS and ALZ:

ncbi.nlm.nih.gov/pmc/articl...

Bolt_Upright profile image
Bolt_Upright

Linh Nguyen wrote a thesis on this topic in 2017:

Stopping Parkinson’s disease with phenylbutyrate: The science, the history, and the miles left to FDA approval

epublications.regis.edu/cgi...

Bolt_Upright profile image
Bolt_Upright

This study is still going on. Pretty low key though. You can read about it in this college thesis: epublications.regis.edu/cgi...

The Study is NOT going on :(

I contacted Dr Freed who was running the study and the NIH refused to continue funding the study and it was stopped.

Bolt_Upright profile image
Bolt_Upright in reply toBolt_Upright

The Study is NOT going on :(

I contacted Dr Freed who was running the study and the NIH refused to continue funding the study and it was stopped.

JayPwP profile image
JayPwP in reply toBolt_Upright

Thanks

Not what you're looking for?

You may also like...

What is AMX0035, and Why Is It Important for All of Us?

AMX0035 is a drug combination of sodium phenylbutyrate (PB) and tauroursodeoxycholic acid (TUDCA)....
SilentEchoes profile image

Recent Research Result: α-synuclein may originate from the kidney and spread to the brain.

"These observations suggest that eliminating circulating α-synuclein may be a possible way to halt...
jeffreyn profile image

Brain waste clearance.

More on this topic....
LAJ12345 profile image

Your Brain on Diet Soda: Aspartame Effects on the Brain

“Although aspartame is a known trigger of Parkinson’s disease, the Michael J. Fox Foundation is...
Kia17 profile image

Three distinct brain circuits in the thalamus contribute to Parkinson’s symptoms

Targeting these circuits could offer a new way to reverse motor dysfunction and depression in...

Moderation team

See all
CPT_Aleksandra profile image
CPT_AleksandraAdministrator
CPT_Anaya profile image
CPT_AnayaAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.