Dormant Cells

[danfitz]

parkinsonsnewstoday.com/202...

[park_bear]

Very interesting and promising. Full study here:

cell.com/current-biology/fu...

[TL500]

Does it mean that this only help early stage of PD?Does it help mid stage or late stage of PD?

And is Xadago one of the MAO-B Inhibitor that can wake up the dopamine production neurons?

[Farooqji]

Thanks for sharing this encouraging article my friend!!

[Rhyothemis]

Interesting that GABA inhibits dopaminergic neuron function; wonder if glycine does the same:

pubmed.ncbi.nlm.nih.gov/156...

[Zardoz]

I was diagnosed in early 2018 and have progressed to the point where I'm on (6) x 25/100 carbidopa/levodopa plus (2) x 5mg Selegiline (mao-B inhibitor) per day. I have my doubts about the article.

[TL500 in reply to Zardoz]

Is it same as Azilect and Xadago?

[Zardoz in reply to TL500]

They're in the same class of drugs, MAO-B inhibitors.

[TL500 in reply to Zardoz]

How long have you been on selegilene?

Ànd no help?

[Zardoz in reply to TL500]

Selegiline extends the 'on' time by inhibiting the breakdown of dopamine by the MAO-B enzyme. Been on it for about a year. Helped me a bit but it feels like the on time is shrinking.

[HugoRipanykhazov in reply to Zardoz]

Do you have any idea whether the selegilene actually does anything? I see you have increased the dosage so i assume there is some reason why you did this?

[Zardoz in reply to HugoRipanykhazov]

The dose is limited to 10mg in two doses of 5mg.

[wriga]

"This research refutes the common belief that there is no disease-modifying treatment for PD due to its basis on neuronal cell death,” said Hoon Ryu, PhD, a researcher at KIST Brain Science Institute, in South Korea, and one of the senior authors of the study."

Whoever came up with the crazy idea that neurons are either "dead " or "in good health " with no place for "damaged" or "not working properly", condemned generations of PD sufferers to a slow death.

Of course there have to be conditions in between these 2. This is the case for all forms of life. These researchers don't go far enough for me. They propose 3 states: Alive, dormant and dead. In the Alive state, neurons will exist as a full spectrum of populations each with a different state of health as with all living organisms... just like Covid19 patients, we must not accept our neurons being classified as lost just because they are very sick.

"SAVE OUR NEURONS " We know they are not dead. Even the very modest Broccoli seed tea experiment tells us that.

wp.me/pc57vK-1o

[Turnipbarrow]

Hi. Saw your posts about ibogaine and am wondering if you are still taking it and what your long term experience with it has been. My husband’s functional neurologist was telling us about ibogaine today. The only thing he knows is about going to clinics in Mexico . You were talking about micro dosing which interests us very much. Then of course there is the issue of where to get it.

Thanks so much!

[danfitz in reply to Turnipbarrow]

Yes, I am still taking it when I can get it. And I believe it is responsible for preventing further decline but supply is an issue. So I have only been able to use it sporadically. What use was your neurologist contemplating? The clinics that I am aware of administer 'flood doses' to treat addiction. Those doses are quite large and I have never read anything about taking such large doses for PD. I modeled my use of ibogaine from the ibogaine/b-vitamin drug patent for the treatment of PD. Am I missing something?

Recently I started 9-MBC and two mushroom extracts (turkey tail and lions mane) and think I am beginning to notice positive results but it has only been a few weeks. With Ibogaine I had immediate improvement and then had gradual continuing improvement.

Best wishes.

[Turnipbarrow]

Thank you so much for responding! I don’t think his doctor has worked with imogaine- his conversation I think was based on whatever research is out there. He said that he hadn’t seen any studies with micro dosing but mentioned it as an option.

Can you share where you do get it when you do? Do you know if they sell it in Australia? Canada?

He also mentioned mushrooms. He was really just putting it out there for us to know about it. Tomorrow when we see him I will talk more about this.

Do you figure out your dosing by yourself or do you hsve someone guiding you? Are the mushrooms easier to get?

Thanks for your help!

[danfitz in reply to Turnipbarrow]

Is “functional neurologist” a euphemism for chiropractor?

From what I have read I would be exceptionally cautious about someone who suggested flood dosing of ibogaine for PD. You might want to quiz him about his sources.

Best wishes.

[Turnipbarrow]

Hi again. Can you tell me where I can learn about ibogaine/b-vitamin drug patent for the treatment of PD.

Thanks so much!

[danfitz in reply to Turnipbarrow]

patents.google.com/patent/U...

[Turnipbarrow]

Thank you so much!

Just to clarify the doc wasn’t suggesting we do a flood. He was just letting us know about Ibogaine and that the research he has seen has been with flooding.