Dystonia from Mirapex

[Debsten]

Has anyone else gotten Dystonia after taking Mirapex. I started on Mirapex, along with Lexapro and Klonapin a year ago. As well as sinemet which I was already on. Since adding the Mirapex and other drugs I started getting Dystonia, in my toes at first, then ankle, then whole food and lower leg. Now in my back to the point that my back arches so far back it is like I’m trying to do a backbend (that flexibility is long gone 😀. Started just if I was walking fast before meds (I could always go for a walk, bike ride, play tennis before meds, was a little stiff but could do it). But has gotten a lot worse to the point of waking up with it. I can’t help but think it is something in the drug combination they started me on a year ago because I had zero Dystonia before that. But maybe it is just coincidence. Anyone else have this problem?

[Debsten]

Forgot to mention Trazadone also. At night for sleep. Age 43. Diagnosed 3 years ago.

[park_bear]

Too much dopaminergic(Sinemet, Mirapex) medication can cause dystonia. Why not cut back?

[Debsten in reply to park_bear]

I cut back on Mirapex, trying to cut back more. I only take .250mg 3 times a day now. But anxiety ramped up when I totally cut back before so need to do it slower than dr said I think.

[MarionP]

Yes it can do that. You may have to drop the dose back. There is some disproportion between the dopamine signals going to the nerves that tell muscles to flex versus the dopamine signals that tell muscles to extend. If mirapex was the only change in a short period, then it would seem the change might be due to the difference between signals going to the first set of nerves and the second. You see, balance between two opposing forces is involved whenever you're dealing with nerves that signal muscles, and sometimes there are two opposing forces rather than one being on and the other being off, and if the signal influences one over the other, they will flex harder and you will get dystonia if they don't turn off or even out the signal between the two opposing"on" forces. It's also possible for the muscles doing the flexing to be inhibited by the medication so that they are forced into a constant flex, hence the strain of dystonia from always having those muscles turned on and never being able to turn off and that's where you get that Charlie horse constant strain and then break down and pain, and if it involves a joint such as wrist or finger knuckles toe knuckles ankle, they can be forced into a constant one way contracture.

actually I wouldn't know whether a decrease or increase would be in order, or some other combined changes in your medication regimen, I wouldn't know which would be appropriate I can't even think of the possibilities that would make sense or not makes sense, so really so as to not leave any out I certainly would st start just briefly trying to get a little relief by backing off the dose a little bit and immediately, until the symptoms subside, and then gradually approach some sort of point where the effects are more positive, and then gradually proceed from there, if it was me, which it's not. but I can't think of everything that would be appropriate and I don't know what would not be appropriate it may be something else entirely to do, so really I would immediately get a hold of my practitioner. Who had done the prescribing.

But first I would immediately get in touch with my prescriber, because the truth is I don't really know if this is a temporary effect and would resolve just with your system getting used to that medication, or whether it's a problem from having too much too soon...since either could be the possibility or even something else, really you want your professional to talk with you about this. As I'm sure you learned from the guy who said he peed into a bucket with some bleach, playing with chemicals can be dangerous.

🐶