Mannitol, L-Serine, and Whole Coffee Cherry Concentrate

[Getz]

I do apologize. I have had a number of people contact me over the above and thought I'd posted internet links to the research.

I learnt about Mannitol from Gwendolinej and that began another episode of research which found that Mannitol kills alpha-synuclein in the gut and so prevents it travelling up the vagus nerve into the brain where it misfolds neurons etc. L-Serine is an amino acid that also crosses the blood brain barrier and starts unfolding the misfolded neurons, and lastly the whole Coffee Cherry Concentrate increases BDNF in the brain by 143% and it is this increased BDNF that is needed to create new brain cells.

Two of these reports are from PubMed which is all French to me so I may have made a misinterpretation or two. Here are the links and I sincerely apologize.

au.iherb.com/blog/l-serine-...

pubmed.ncbi.nlm.nih.gov/236... (Mannitol)

pubmed.ncbi.nlm.nih.gov/233... (Coffee Cherry)

[park_bear]

The paper you linked to regarding coffee extract does not mention "cherry" so you might want to remove that from your title and text. Also, a discussion of coffee and Parkinson's here:

healthunlocked.com/parkinso...

The L – serine treatment is for ALS. No effect on Parkinson's as far as I know.

The mannitol article is good, it sets forth the reasons to believe that mannitol is effective for Parkinson's.

[rescuema in reply to park_bear]

coffee fruit = coffee cherry

Here is a better article with links to many more studies.

healthline.com/nutrition/co...

[Getz in reply to rescuema]

An excellent article on coffee fruit/cherry. I don't know how I missed it as I am a regular reader of Healthline. Thank you.

[Getz in reply to park_bear]

Thanks. I could change it to coffee fruit as that is what is referred to in the article. Many articles refer to it as cherry. So long as you don't get confused with the whole coffee bean. Shall try to figure out how to edit it.

[SilentEchoes in reply to park_bear]

L-serine should be tried - there is considerable overlap in neurodegenerative disorders and AD, PD and ALS are not mutually exclusive. I see research more often now that addresses all three together. Someday medicine will catch up with the human experience and and acknowledge that these neurological injuries are related and exist on a spectrum.

SE

[park_bear in reply to SilentEchoes]

Have you tried it? Did it help?

[Smittybear7 in reply to park_bear]

How much mannitol should you use each day?Can you mix it with cinnamon and spread on toast? Can you use it in place of sugar in recipes? What is the best way to use it.?

[park_bear in reply to Smittybear7]

I am not the best person to ask. Mannitol did not agree with me so I do not use it.

[Shaky-hand in reply to Smittybear7]

Hello Smittybear7,

I have taken mannitol for the past 6 years. Initially it caused bloating, gas and helped with rectifying constipation but my body quickly adapted to it.

It is a weak sweetner so I am not sure if you could use in place of sugar in recipes. I use to take two heaped teaspoons per day in my morning coffee or tea or sprinkle it on my oatmeal. It is a white powder and would not spread on toast with Cinnamon. Presently I take two heaped teaspoons in water along with my powered Vit C, MSM, and Magnesium.

Karen

[Smittybear7 in reply to Shaky-hand]

Does it relieve tremors? Do you take b1 ? Do you take b1 separate from magnesium?My nutritionist/pharmacist said to take them separately.

[Smittybear7 in reply to Smittybear7]

Thanks

[Shaky-hand in reply to Smittybear7]

It does not relieve tremors it appears to help the slowness and stiffness. I take Amantadine 100mg twice a day to decrease my tremor but wished I could find something else because of the side effects. It has caused a skin and what sounds like a circulatory condition called Levidio Reticularis and my vision has decreased drastically. I tried to wean off slowly but ended up feeling awful that I started again and immediately felt better, wished I never started.

I have taken HD B1 for five years now. Initially 1 gram per day. It helped a lot and I was able to use my right arm better to function but my tremor got worse. I decreased the dose to 500mg after about six months and take 500mg once a day. I am 5’ 1” and weigh only 90 pounds. I take B1 in the morning and magnesium at night.

[Vegegardner in reply to Shaky-hand]

Do U think you go down hill without mannitol Where to get. What brand? How many grams do U take.? Thanks for sharing

[Getz in reply to Smittybear7]

In one of the research articles I read they recommended 12g /day. It gave me too much gas if taken in the morning so I simply take it in the afternoon.

[Smittybear7 in reply to Getz]

Thanks

[Propertytyphoon]

Hi are you aware of any further research, more recent perhaps as this 7 yrs old, thanks

[Getz in reply to Propertytyphoon]

Sorry, no.

[KERRINGTON]

What brand of L-Serine do you use, and do you have a runner up favorite for coffee cherry concentrate...Swanson is sold out ( I wonder why ? ) Thanks for sharing so much !

[Getz in reply to KERRINGTON]

I have used the Lake Avenue Nutrition brand from iHerb but they have another cheaper brand but it was sold out. Maybe I bought the last lot of coffee cherry from Swansons.If so i am sorry. There must be other suppliers or if you are in the Whitsundays in Nth Qld Australia you could buy some off me at cost. I bought enough to last me till June.

[Baron1]

The "Whole Coffee Fruit" studies appear to be fanciful. My mother has been taking this for the last "10" weeks and not a single aspect of her condition has changed; not even slightly.

The brand she has been using: Bulletproof - Neuromaster.

So unless someone has seen some results from personally taking the coffee fruit / coffee berry fruit extract, then it has limited benefits from what I have physically witnessed.

Best to all, and hope 2021 is a better year.

[Getz in reply to Baron1]

I agree with you bud. Unfortunately we read the research and start to trial it and we don't notice a thing. Unfortunately if you are not part of a trial you will never know as we do not undergo the assessments. I'll stick with it purely in the hope that the science is right. It is inexpensive'

[LAJ12345]

Thanks Getz. I did google it and couldn’t find your post so thanks for posting.

Sorry, did you post a link anywhere to a particular brand ? Trying to find a cheap but safe one.