Am really interested in this new info that has come up.
"In pre-clinical tests, when brain cells exposed to BMAA were also exposed to L-serine it prevented the formation of misfolded or unfolded proteins. Furthermore, L-serine prevented an increase in the formation of an enzyme that causes brain cell death that is induced by BMAA."
Am certainly going to give this a trial as there appears to be no downside. I also checked with PubMed and there are many supporting research articles.
I just read the blog post on i-Herb and it does sound interesting. Do you have any ideas about dosage? One manufacturer talks about 2g per day, and the author of the article talks about 15g 2x per day. That's a wide range. Thanks - JG
As with all of these things there is a great variation depending on the individual. Just take thiamine as an example. Both this blog and the pubmed article mentioned 15g twice daily.
That would be about a Kilo per month
Certainly seems a lot 900g but what is one to do? My physical problems with PD seem to be getting better but nothing has changed with my sudden temporary memory losses eg forgetting names of people you know really well. I believe that PD is involved with a-synuclein which originates in the gut and travels up the vagus nerve to the brain where it starts its misfolding. A healthy gut will minimize the amount of a-synuclein so this is the long term solution but in the meantime if something can prevent any further misfolding of neurons etc its certainly worth a try and as new neurons grow they will no longer be attacked by the a-synuclein.
I don't see the L-serine as a long term treatment. My long term treatment is gut health and the inclusion of probiotics which attack a-synuclein.
Really good chance that I'm wrong and looking at PD over simplistically but for me its worth a try and if no improvement in a couple of months it'll fall by the wayside.
Good luck with it Getz, and let me know how it goes. Meanwhile I had a B1 injection today. My schedule had been disrupted by the Labor Day holiday, so it had been about a week since my last shot. Within about 30 seconds I remembered what it was to feel “normal” again. Heartfelt thanks to Dr C and associates for HDT.
Getz,
How did the trial with l-serine go? Are you still taking it? Would very much appreciate your response!
Mate, to be absolutely honest, I don't know. I have been gradually reducing the heap of supplements I've been taking but am still sticking with L-serine in my smoothie. Have bought a HaloSport and I wouldn't be surprised if it is having an influence. It's certainly worth googling. Walking quickly for an hour 3x weekly, my breakfast smoothie, the helmet,
and now the halo sport seems to be holding things at bay.
Thank you, Getz for encouraging news - as long as you can hold things at bay means something must be working. I've never heard of HaloSport but found some information online, do you know any PWP who used it?
I've not heard of any, but the logic is that if it improves athletic performance by neuropriming the brain cells that control muscles, then it should also work with the muscles that give us the tremors. After the 20 min neuropriming I then alternate between handwriting and balancing on a bit of 2x3 inch wood. I am now comfortable on the 3" side so will be moving on to the 2" side soon
That's interesting, hope it will help you to improve PD symptoms - there is so much to learn!
12/01/2020
2 support group members used the Halo 2 (don't think it is available anymore. not sure). They would not buy it again. Flimsy...loses connection quite easily. Apps don't work.
Mainly useless. Their evaluations; not mine.
Sharon
I found Halo Sport to be excellent quality and it worked really well for me. I used it to improve balance and handwriting. Balance I improved from standing on a 3" plank to a 2" plank and my handwriting lost its shakes so I could write my signature again. I hardly have any hair so connection with skin was easy.
I heard if you were bald it worked OK. LOL
Did you ever try any other approach, i.e. "red light" hats, etc?
I bought a helmet from the men's shed in Tasmania. It has 2 frequencies 670nm and 810nm. I have 20 mins each frequency daily. I really think the hours fast walk 3x weekly is one of the most effective treatments but I'm getting slack over summer as it is so hot in Nth Queensland.
NQ? Tasmania? no way. Cairns is actually a decent size. Far North Q is pretty remote, way way remote. (no I don't live in Aus, but have gone there)
Helmet---
1) what brand? How long have you used it?
2) is it more effective than fast walking?
3) do you swing your arms when walking?
4) how many years from initial formal diagnosis?
sharon
"NQ? Tasmania? no way. Cairns is actually a decent size. Far North Q is pretty remote, way way remote. (no I don't live in Aus, but have gone there)"
????
Getz...lives in NQ.
So it was just a burst of thoughts on various Australian things? I see
No idea what you are trying to imply or convey
"burst"? rare compliment.
Been using the helmet for a bit over a year. Its made by the Dorsett Men's shed to Max Burr's design. I also do fast walking. It is not an alternative. I do and take quite a few things but I'm finding that stress really sends me backwards. Have had doctors diagnosis not neurologist. I cured prostate cancer naturally and as everyone says there is no cure for PD I'm not going to waste time and money on that approach.When I first started researching 4 years ago I couldn't hold my latte in my right hand but now I can. I also had a floppy left foot when walking and that is now fine.
Thanks for the hat info. Really the Hamiltons's design (Red Lights on the Brain). Do you use the "Eliza" model? or Cossack?
Fast walking a la John Pepper?
Stress is a big no-no for PD particularly chronic stress from worrying too much.
Glad things are working out for you.
12/03/2020 CDT USA
Getz,
Since you have had some success in reversing some of your motor symptoms, which is not typical, would you mind "ranking" your strategies in order of effectiveness? I would like to bounce your thoughts off my support group members. I am always looking for new ideas.
Sharon
I'd probably put fast walking first as it also has benefits for general health. I think I felt a noticeable improvement after a week on mannitol, L-serine and coffee berry. I did see a marked improvement after using Halo Sport 2. I could sign my signature and I didn't fall over while putting my undies on. As to the rest I have no idea but I'm not cutting them out.
Hello ! How much mannitol do you take, and what is coffee berry ? Thanks !
12g mannitol once a day is the recommended dose. It was more effective than twice a day in the trials. 15g of L-Serine twice a day. 200mg capsule of coffee cherry concentrate twice a day in the pubmed report increased BDNF by 143%. Coffee cherry is the fruit that surrounds the coffee bean.
#1 --- Mannitol - does it work for PD?
12 grams of mannitol "orally" is a whole lot of mannitol. Roughly 1 level tablespoon which contradicts the Israeli cell bio/fly/mice study which says mannitol's effectiveness is not dose dependent (Karyo), i.e. less is better (=0.225% aggregation showed the best results.) "Curiously the low levels of Mannitol had the strongest inhibitory effect, while the higher concentrations had no effect." This conclusion was contradicted somewhat by Seo et al (2016)in their brain tumor resection study. Higher doses worked best but came with more AEs.
As to PD clinical trials using mannitol, Hadassah's (A. David) Phase 2 will go up to 18 grams. I can find no other mannitol PD CTs. Several CTs have been done on mannitol and intercranial edema (also CF, renal failure, etc.) using as a bolus (avoiding continuous infusion) up to 1g/kg!...via IV. However, mannitol therapy showed mixed results in these types of CTs (i.e. acute stroke clinical trial, 2003, etc)
Yet we find one source claiming: "Mannitol reduces the concentration of free radicals that promote cell membrane lipid peroxidation and ultimately destruction of cellular tissue. It also promotes cerebral blood flow by reducing blood viscosity and microcirculatory resistance."
Different perspectives on this simple sugar.
Sharon
Thanks so much. Interesting.
Hi! Do you use both the Halo Sport and helmet everyday ?
Definitely. I have the Halo Sport on for the 20 min neopriming then I put the helmet on for 20mins each frequency and while its on I practice handwriting and balancing on the bit of 2x2" simply alternating between the 2 .
12/01/2020
2 support group members used the Halo 2 (don't think it is available anymore. not sure). They would not buy it again. Flimsy...loses connection quite easily. Apps don't work.
Sharon
Thank you Sharon for letting me know.
Hi Getz, Did you ever try L-Serine? If so, how did that go, or how is it going?
I've been putting a scoop in my breakfast smoothie daily and have recently ordered some more. I have no idea whether it is working or not but the science behind it is sound so I'll keep at it until something better comes along.
Thanks Getz! Best of wishes to you. Please update us when you have changes on this!
Have just read an article on NAC which is a building block for Glutathione so will probably trial that as well. As you see I am a bit on the nutty side and don't mind trialling anything that doesn't have negative effects.
Thiamine deficiency review : endoplasmic reticulum & protein misfolding
C/L CR recommended for overnight treatment 
Can PD get better? 
What do you know about L-serine 
