Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

[Farooqji]

Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

New biorxivpreprint manuscript suggests that Brazilin (a small molecule derived from red cedarwood trees in Brazil) eliminates seeding competence of synthetic & Parkinsons brain-derived α-syn assemblies, & significantly reduces their toxicity

biorxiv.org/content/10.1101...

doi.org/10.1101/2020.09.29....

[jimcaster]

I just glanced at the Abstract, but it's not clear to me whether this result was produced in a test tube, a fruit fly, a mouse, or a human. Do you know?

[Rhyothemis in reply to jimcaster]

test tube & cell culture (neurons from mice)

[Fighttolivenow in reply to jimcaster]

Test tube....most of the paper was over my head...but looks like they got some alpha synuclein samples from pd brains patients post mortem ..