New gut microbiome research article

[Rhyothemis]

Characterizing Dysbiosis of Gut Microbiome in PD: Evidence for Overabundance of Opportunistic Pathogens

nature.com/articles/s41531-...

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They found more Prevotella, which is the opposite of what had been found in previous studies. The authors suggest this may have to do with using different taxonomic classifications.

So I'm wondering if I should stop using xylitol since it increases Prevotella... hmm...

[pvw2]

When I look at their figure 1, I don't see a statistical difference between the PD cases and the controls. While they used statistics to show a difference, they need a larger database to make it believable. What does look significantly different is Birmingham, AL. So the question is: Are the percentage of PD cases in Birmingham, AL, significantly different that the other locations?

[Rhyothemis in reply to pvw2]

Yeah, it doesn't look right, does it? What's weird is 'Cases and Controls' looks different from both 'PD Cases' and 'Controls'. Perhaps I'm interpreting it wrong. I remember doing PCA analysis on bird songs (using measurements from spectrograms) for an experimental design course at uni and the clusters generated corresponded to species quite neatly - the plots were not hard to interpret at all. But this is published in Nature, which is highly reputable and has a low acceptance rate. Hmmm ...

[pvw2 in reply to Rhyothemis]

It is data that needs lab measurements not normally made, so there isn't a large source of data such as is the case with Terazosin . While the authors might be showing a higher confidence that the actually confidence level of the data, the data does motivate more research.

[sharoncrayn]

Is this study the same we have seen posted twice before in the last week or so? Think it is.

Braak's theory, which is the basis of this study, is so far out there in left field I really doubt if it has any applicability in the real world. Will this study motivate more research in Braak's theory? Don't know, but not much has been done with his theory since Braak published his papers because his populations of PwP were younger than normal, and of a longer duration than normal.

Nature's reputation isn't what it once was.

Sharon