Alpha-synuclein in the nucleus, DNA repair, butyrate.

[aspergerian]

Tydbyts:

Alpha-synuclein in the nucleus, DNA repair, butyrate.

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders. 2019.

ncbi.nlm.nih.gov/pmc/articl...

Alpha-Synuclein Modulates the Physical Properties of DNA.

2018. Pmc.

pubmed.ncbi.nlm.nih.gov/301...

Selective Binding of Nuclear Alpha-Synuclein to the PGC1alpha Promoter Under Conditions of Oxidative Stress May Contribute to Losses in Mitochondrial Function: Implications for Parkinson's Disease.

2012.

pubmed.ncbi.nlm.nih.gov/227...

Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage.

2017.

academic.oup.com/hmg/articl...

[Getz]

Great info. Many thanks.

[alexask]

Is this the thing that Mannitol increases?

[akgirlsrock]

Should we be taking Sodium butyrate?

[aspergerian]

See "iron" in:

Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease.

2018.

ncbi.nlm.nih.gov/pmc/articl...