"Natural products targeting cellular proc... - Cure Parkinson's

Cure Parkinson's

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"Natural products targeting cellular processes common in Parkinson's disease and multiple sclerosis."Shamans & Witches giving meds. SAD.

Thal profile image
Thal
4 Replies

I believe that the trend turning to natural products instead of evidence based medicine is dangerous and regressive. SAD.

frontiersin.org/journals/ne...

Conclusion

NP s are Natural Products.

The diverse functions of the select NPs organized in Figure 2 and reviewed herein bode well with many beliefs in the field while revealing some interesting trends. First, PD and MS share many characteristics, especially in terms of neuroinflammation and OS. It is therefore not surprising that NPs capable of ameliorating PD symptoms have similar effects on MS. In this regard, to select NPs targeting a cellular/subcelluar process of one disease, one can draw on the knowledge of NPs that had been investigated for the same process of the other. A large stockpile of NPs has been examined thus far for only PD or only MS. At least some of them can be repurposed reciprocally or even for other neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. Second, among the countless NPs, special attention should be given to those that have displayed efficacy in modulating/intervening multiple cellular processes and signaling pathways, owing to the complexity of both PD and MS. Third, from Figure 2 it is apparent that even an NP possessing different functions is incapable of counteracting all the detrimental effects inherent in the many factors or processes. Thus, the combined use of multiple NPs might be needed for regulating the different pathways. Fourth, NPs have shown great promise in addressing the pathological processes for which no clinical drugs are available. Even for processes that have been dealt with by clinical drugs, NPs offer as alternatives to afford equally effective treatments without severe side effects. Finally, an increasingly accepted notion in the PD field is that inflammation is significantly manifested. In particular, increased levels of pro-inflammatory cytokines, activation of the immune cells, and their infiltration through a more permeable BBB are hallmarks being recognized. As these processes have long been studied in the MS field, many NPs and their known functions are likely translatable to PD research and modalities. As the research continues to progress from cellular and rodent models to primates and patients, it is foreseeable that the vast pool of NPs should afford at least a few highly effective therapeutics with low or little toxicity.

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I think drifting and reliance on so called natural herbal concoctions is regressive and dangerous. Beware and skeptical. Pseudo science and alternate truths, cons and shams are becoming the norm.

Like the above they make it sound so good when in fact it's going to end badly. SAD.

We are very vulnerable because we are mentally compromised and subject to the placebo effect,

youtu.be/tMChb7Odf2Y?si=_5g...

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Thal
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4 Replies
park_bear profile image
park_bear

This paper is a review of the research of the effects of natural products on Parkinson's and MS. Nothing wrong with it. Thiamine is a natural product and high dose thiamine has helped many here.

Example text from the cited paper:

"NPs [Natural products] have been identified to inhibit the formation of α-syn oligomers and fibrils, disaggregate aggregates into non-toxic forms, or disrupt their interaction with lipid membranes. EGCG was demonstrated to inhibit fibrillation and disaggregate fibrils, thus enhancing cell survival (48). Curcumin can prevent α-syn aggregation in LPS-induced PD model (117). Baicalein was shown to inhibit fibrillation of the wild-type α-syn and disaggregate fibrils, as one of us found with his co-workers (118). It can also disrupt fibrils of an α-syn mutant (119). Crocin can inhibit α-syn aggregation and disassemble mature fibrils (120). We found that ginnalin A is effective in disrupting the oligomerization and fibrillation of both α-syn and amyloid-β peptides (121), in line with the finding that an NP effective in inhibiting the aggregation of one amyloid species is often capable of acting the same way on another. Alkaloids such as synephrine and trigonelline can also inhibit seed-induced α-syn aggregation, increasing cell viability of SH-SY5Y (122). Squalamine (123) and trodusquemine (124) were reported to inhibit lipid- and fibril-induced α-syn aggregation and alleviate α-syn toxicity to cells. They also showed promising treatment results in animal model studies (124, 125)."

Thal profile image
Thal in reply to park_bear

All things being equal you are correct. The problem I'm having is natural products are unregulated and not standardized.. So the conclusions are not medically reliably reproducible.

I've found myself trying natural products ex. Mucuna to discover frustration and disappointment because of the variations.

Therefore I've concluded that the natural products industry is broken and not salvageable.

park_bear profile image
park_bear in reply to Thal

You're not the only one to have reported that problem with mucuna. On the other hand, in the case of cinnamon, the active ingredient, cinnamaldehyde, is what gives it it's characteristic aroma, so if it smells like cinnamon should we have an indication it is good.

Thal profile image
Thal in reply to park_bear

Thank you.

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