Opicapone not lasting 24 hours

[mandolinmann]

Can Opicapone be taken in the morning instead of the evening? This would be more useful as it's effectiveness does not last for 24 hours.

[sharoncrayn]

Opicapone (COMT inhibitor) is an EU drug which should be used once a day with sinemet or rytary according to your physician's protocol.

It is what is called "an end-of-dose" drug because it was developed for that very specific purpose, so morning ingestion seems rather contradictory IMO.

Dyskinesia was relatively common in the CTs.

[gingerj]

I'm due to start opicapone as soon as I can get some with stock being low. I too was curious why we're told to take it the evening yet moab inhibitor can be taken first thing?