Wonderfully informative discussion in Dia... - Cure Parkinson's
Wonderfully informative discussion in Diabetes and Parkinson's disease. See Rescuema comments: Thiamine inhibited by metformin
Osidge and Rescuema, the two primaries. Wow!
About Bill Walsh:
healthunlocked.com/parkinso....
47 cite WC Walsh 2004: Reduced Violent Behavior Following Biochemical Therapy.
scholar.google.com/scholar?...
Dr. Walsh is just one of many working on epigenetic reprogramming, but the Walsh institute does have the world's biggest chemistry database collection of myriad mental disorders, and successfully treating them.
"These mice, it seems, have sipped from a fountain of youth. Izpisúa Belmonte can rejuvenate aging, dying animals. He can rewind time. But just as quickly as he blows my mind, he puts a damper on the excitement. So potent was the rejuvenating treatment used on the mice that they either died after three or four days from cell malfunction or developed tumors that killed them later. An overdose of youth, you could call it...
'Then you’re starting life again.' Even skin cells from centenarians, scientists have found, can be rewound to a primitive, youthful state...
In Japan, researchers began an effort to reprogram cells from a Japanese woman in her 80s with a blinding disease, macular degeneration. They were able to take a sample of her cells, return them to an embryonic state with Yamanaka’s factors, and then direct them to become retinal cells. In 2014, the woman became the first person to receive a transplant of such lab-made tissue. It didn’t make her vision sharper, but she did report it as being “brighter,” and it stopped deteriorating...
they demonstrated that cell reprogramming could actually occur inside an adult animal body, not only in a laboratory dish. The experiment suggested an entirely new form of medicine. You could potentially rejuvenate a person’s entire body...
Wholesale rejuvenation, then, is still far off, if it will ever come at all. But more limited versions of it, targeted to certain diseases of aging, might be available within a few years."
The forum's cell biologists are at it again with citations they can't explain but just love to theorize about...
Another trip deep into the weeds where anything is possible as long as it is theory..
Sharon
As do you. Someone has to in order to reach progress, especially when combined with myriad anecdotal evidences.
Everything is theory until it isn’t. These posts are useful.
Unfortunately, most cell studies remain totally unproven when moved to the human model. Therefore, I remain very skeptical of most of them and pay very little attention to the posts that attempt to explain them. However, you are welcome to your opinion.
Sharon
I suppose you didn't even bother to read the studies. I don't see thousands of rats.
Believe me, I read several hundred cell studies a year which is 400-500 more than anyone you know. Just look at my history of commenting on them on HU or ask aspergerian if I don't consistently comment on his citations (if they are remotely relevant or timely) with an explanation of what the study researchers are claiming or suggesting.
I don't have a Ph.d. in bio chemistry (which means I have a Ph.d. in both biology and chemistry) with a ton of experience over 30 years in cancer research and clinical trials for nothing. Cell studies are part of research, sometimes important, but most of them end up buried in the file cabinet because they are obtuse or completely theoretical with minimal hope of translation to the human model.
The Chinese micro biologists are big into cell studies of all kinds and types, which makes one wonder about Covid-19, or it should. In early March, a couple of them authored a scary micro biology study of the Angiotensin-converting enzyme 2 (ACE2), which is the receptor of COVID-19. IMO, this cell study is very relevant, but probably will never see the light of day.
Sharon
Did you mean to say that you do have a PhD in a biochemistry??
Thanks for the typo check. Missed it.
I have a Ph.D. in biochemistry which means I have an equivalent Ph.D. in biology and chemistry with a major concentration in one or the other by personal preference. Since I majored as an undergrad in chemistry, my focus in grad school was chemistry.
However, both disciplines are pretty strong in bio chemistry.
Sharon
The application of targeted nutrient therapy for powerful epigenetics impact changing the chemical reactions at DNA/histone tails level to modify gene expression is very real, and human applications for successful clinical benefits have been well established to the point now there are over 600 trained physicians (MDs, NDs, psychiatrists, etc).
It's cutting-edge science, not a hogwash.
walshinstitute.org/resource...
The Walsh Institute? Sorry, that is science? Hmmm. May have to double check my OED on that one.
Indeed- Addressing and changing the course of diseases through bona fide targeted therapy addressing SNPs at genomic level is where the future is headed as to depending on toxic pharmacology for symptomatic relief alone shooting in the dark. The link shows many convinced physicians actively applying the nutrient therapy who are converts after assessing the undeniable evidences, albeit most started as skeptics themselves. Still way behind of full potentiality but we’re definitely headed where gene regulation can be modified at DNA methyl/bookmarks in addition to the continued progress of nutrient therapy.
Indeed- rhetorical pivoting? A minute ago it was "cutting edge science," as if that meant trustworthy helpful fact-based safe treatment.
So which is it, seems hard to get my OED to treat them as the same. Sorry, must be mine is a misprint. Or maybe we didn't clarify which "edge" is being "cut." (Or, perhaps, "who's.")
Time to realize earth isn’t flat.
See, I describe actual behavior whilst you call names. Time to realize when you quit by turning over your king, once outed you may be the only one to be fooled.
Oh, by the way, something isn't bona fide until it's proved. Are you commercially selling your institute? Not allowed you know.
Thank you for the link 🌺
You are capable of embarrassing carelessness in interpreting scientific data as demonstrated by your post regarding the pharmacokinetics of L/C and your statement that it was impossible for carbidopa to boost the amount of orally administered levadopa reaching the brain by 500%, in spite of that being common knowledge about the gold standard treatment for PD - a field in which you claim long experience in addition to your academic credentials. Accordingly i am happy to take your conspiracy theories about covid 19 with a pinch of salt but think it important to offer a little reassurance to counter the paranoia. theguardian.com/world/2020/...
The Guardian? Ok, I'm really reassured. 
(By the way, the story was rife with errors and mis-placed emphasis and hidden assumptions, including several mistakes made by their "expert." (...Or by the editor\writer in control of the quotes.)
Winnie:
We in the US have "state of emergencies" in Washington State and New York. Italy has a similar but a much more draconian lockdown in northern Italy with 7400 reported cases with 370 deaths for a whopping 5% mortality rate. Iran is even worse. Asia has well over 100,00 cases even with their bogus under reported numbers.
Dr.Hatchett, who knows more about pandemics than almost anyone else, said:
"This is the most frightening disease I've ever encountered in my career, and that includes Ebola, it includes MERS, it includes SARS. And it's frightening because of the combination of infectiousness and a lethality that appears to be manyfold higher than flu." Yes, Hatchett said it; not some bimbo who writes for your Guardian.
Is this a joke to you? a "conspiracy"? "a pinch of salt"? "paranoia"? Keep reading the Daily Mail and the Guardian and watching the TV. Your sources for true science reporting. Extraterrestials will save you.
Sharon
No. The disease is not a joke. Pretending to know that it was manufactured in a lab is a joke. And hijacking every thread to propogate such nonsense is tiresome
It came out of the Class 4 BSL lab in Wuhan according to the three highly qualified virologists I have talked to, which is three more than you have talked to or even read. Highly likely the building blocks came from some other class 4 BSL lab since the Chinese microbiologist/virologists aren't adept at creating. According to my contacts, The NML in Canada would be a good guess since they sent the two premier Chinese virologists home back in 2018 for stealing viruses and sending them back to China....Dr. Plummer, a virus guru, from the same NML was forced to resign for similar accusations.
I don't "pretend" to know. You do.
Sharon
" it was impossible for carbidopa to boost the amount of orally administered levadopa reaching the brain by 500%, in spite of that being common knowledge..."
This is the 4th time I have asked you for any citation, any type of peer reviewed citation ....from any medical journal to refute my comment that it was impossible.
I am still waiting.
Sharon
Xref the other 3 times for me. I can't locate them.
Winnie;
I will save you the trouble of trying to find my previous 3 requests, let alone any citation to support your ridiculous claim.
Nothing exists in the peer reviewed literature to support anything remotely close to your claim (which I have previously pointed out to you twice). Totally bogus claim. Where or how you came up with it I have no idea, nor do I care.
For me, this ends my involvement in this thread.
Sharon
Sure Shazza. You are not here to debate, but to misinform. And when I ask you for references to support your unorthodox claims you are too busy and important to supply them.
I note you didn't challenge my original source (science direct) but quoted it and misinterpreted it as follows (your quote)
"Inhibition (by carbidopa - sharon) of the peripheral metabolism of levodopa increases the amount that crosses the blood–brain barrier to 5–10% of the oral dose." Hardly significant.
The comment "Hardly significant" presumably applies to reading "5-10% of the oral dose" (a 500% to 1000% increase) as "BY 5-10% of the amount reaching the brain"
Careless. Wrong. Typical.
There are tons of references. Here is one. This is a trial comparing mucuna with C/L and finding a (near) equivalence at 1000mg levadopa to 50/200 CL jnnp.bmj.com/content/75/12/...
It's references 9-13 were the basis for the trial design"This conversion factor was based on published studies comparing clinical and pharmacokinetic l-dopa effects with and without a decarboxylase inhibitor"
"In comparison with levodopa alone the advantages of levodopa-benserazide or levodopacarbidopa are several, but there is apparently little or no difference between the two combination drugs. Their major advantage is that they allow a marked reduction in levodopa dosage without compromising the therapeutic effect. Benserazide and carbidopa diminish the optimum dose of levodopa by about 70 to 80%." link.springer.com/article/1...
Reducing 100mg by 80% reduces it to 20mg. So the 20mg dose with Carbidopa has the same effect as 100mg without. A 500% increase
I state that I did not understand exactly where it was born and why this heated discussion but it seems to me that you speak of two different things I.e. peripheral plasma concentrations vs central system concentration or am I wrong?
Not wrong but joining the party half way. It's not really important - I just resented the arrogant brush-off on another thread. And in particular the casual lazy misinterpretation of data she quoted in applying that brush-off.
So, the issue was my explanation on another thread about why someone was using 1000mg mucuna levadopa as equivalent to 50/200 C/L. And the answer I gave is that it is a common rule of thumb that Carbidopa improves levadopa absorption into the brain by 500%. I then worked the sums to confirm the 16.5 capsules asked about in that post.
Obviously measuring levadopa in the brain is kind of tricky on living humans, so the guide comes from good old rodents and by derivation of effects in humans. The actual clinical response is much more complicated, and affected by protein in diet, accumulation of dopamine levels, microbiome, disease progress, and individual metabolism. But 5:1 is a well established rule of thumb, and the last link for the review of decarboxylase inhibitors in the post above, emphasised that rule in a clinical context. Using carbidopa means you need to use 80% less levadopa to get the same therapeutic effect, which is the same as saying using carbidopa means 5 times more of the orally ingested levadopa gets to the brain.
See:
Lonsdale 2007 Pmc: Three Case Reports to Illustrate Clinical Applications in the Use of Erythrocyte Transketolase
ncbi.nlm.nih.gov/pmc/articl...
Very interesting.
I quote:”Fujiwara et al. (10) showed that both calcium and magnesium are important components of a diet aimed at providing adequate thiamin nutrition. “.
I have always written to accompany thiamine with a good supply of fruit and vegetables to take MINERALS AND VITAMINS MAGNESIUM AND CALCIUM. I don't know of another healthy and appropriate way to do it because I don't trust in multi vitamins / minerals. Of magnesium yes I trust! IMO too trivial to be correct.
Fine. Read them or don’t. It doesn’t matter to me. But please don’t complain about the articles being posted. You are not being forced to read them and some of us find the articles useful.
Dan:
You are confusing my complaint and taking it out of context
The citations are fine; some of them are relevant. The "interpretations" of the study cited by someone who doesn't understand what the study is actually concluding or proposing is my concern because because most of the time the interpretations are quite erroneous.
I have no problem with "opinions" since this is an open forum. Do me the same favor and respect mine.
You are not being forced to read my opinions. Ignore me; you certainly have that choice. I didn't ask you to read my posts or respond to them.
Sharon
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