Do you take B1 in IM injection form?

[Dap1948]

My friend, who is now blind, has asked me to post a question on his behalf. The question is for anyone taking B1in INJECTION form. He asks-

1. Is everyone on thiamine injections taking 100mg x2 a week?

2. Has anyone who is taking B1 in the injection form, found the need to reduce the dosage? What caused this decision?

3. By how much have you reduced? Was this all at once or in stages?

4. Did the early symptoms return when you had reduced?

5. Have you stayed at the reduced level or have you had to reinstate the higher level?

There has been discussion on this site about people reducing the oral dosage, what we are trying to find out is whether people on injections have also found the need to take a break or reduce.

Many thanks

[Fed1000]

For some months now I have been taking B1 in the form of weekly injections (80 mg/0,80 ml) because the tablets (900 mg per day) caused inflammation during that period. The weekly equivalent of 0,80 ml corresponds to just under 2 gr per day in the form of tablets. Honestly I'm not sure that the injections give the same benefits as taking it orally or at least that the equivalence above is exact. I thought I had more benefits with current injections than previous tablets, to the point that I decided to try to gradually reintroduce them sublingual (as from your post) by reducing the level of injections. I hope I have answered you questions at least in part.

[chartist]

Dap & Friend,

I'm pretty sure Gio has mentioned both taking a mini vacation from the injections as well as taking an additional injection now and then. Maybe he will chime in to explain further, but basically I think he decides by the way he feels.

Art

[Dap1948 in reply to chartist]

Unfortunately my friend can no longer be very flexible. He is no longer able to see to measure his dose and a nurse comes but will only measure what has been agreed by the doctor. If my friend wishes to change the dose he has to go through many hoops at the surgery to get it adjusted it seems.

[MBAnderson]

I started 1 mL injections in October 2018 and was pretty religious about it for a year, then I slacked off. Then I was taking them irregularly, i.e., once every 10 to 20 days. I haven't had one for a few months, but I will start back again. Going on and off has not mattered to me. I have not been able to connect any benefit to B1, but I take a lot of other stuff. I often take 500 mg orally. I started 4 g per day and after year or so quit. I take an oral dose a few times a month now.

[Xenos in reply to MBAnderson]

Same same...

[Gioc]

As I have written in the past I have been doing number 2 I.M. x100mg for almost 5 years without ever changing the dose, without any known side effects. Sometimes I suspend a week in case of overdose symptoms then I always resume at the same dose (2 x 100mg week). As soon as I stop for more than a week the non-motor symptoms such as constipation and fatigue increase a little, so much so that my wife immediately notices it. My experience is very similar to yours with sublingual pills. I've never changed and I feel good. I think that I.M. assimilation is much more linear and gradual over time and doesn't need correction. With b1 I rarely experience fatigue, while tremor and stiffness are resolved by madopar. The Thiamine has known effects and I know them very well.

I don't use other vitamins or minerals all the time, or any other substances or supplements other than madopar, so after so many years I know for sure what b1 can or cannot do. Before I was diagnosed, 9/10 years ago, I had symptoms of PD which improved with the use of b1 in pills at a dose of 300 mg, (BENERVA extended release) this without knowing I had PD.

IMO the sublingual form of b1 is comparable to injections as your experience is very similar to mine.

[Dap1948 in reply to Gioc]

Thank you for replying. I will read out your reply when I Skype my friend. I'm sure he'll find it helpful. He reduced and met all his symptoms again so he's working his way back again.