LRRK2 mutation related to PD is reducing ability to recover from viral infections

[felixned]

My local support group published this link:

cureparkinsons.org.uk/News/...

According to this publication G2019S variant of LRRK2 gene that is commonly found in PD dramatically changed recovery from viral infection in transgenic mice.

The leucine-rich repeat kinase-2 (LRRK2) gene has been associated with Parkinson’s disease, leprosy, and Crohn’s disease. We examined whether Lrrk2 plays a role in virulent infections. In mice carrying different versions of Lrrk2, we found that Lrrk2 altered the course of bacterial and viral infections by modulating inflammation. Animals expressing the Parkinson’s disease–linked p.G2019S Lrrk2 mutation showed reduced replication of a bacterial pathogen. During viral encephalitis, the p.G2019S Lrrk2 mutation worsened survival in mice, predominantly in females. Animals with viral encephalitis expressing a variant that blocked Lrrk2’s enzyme function showed improved survival. Lrrk2 may modulate the course of microbial infections in a manner that depends on mouse genotype, sex, and the type of pathogen.

I still think that viral disease etiology doesn't get enough attention.

[Gioc]

in this article it is theorized how LRRK is related to alfasynuclein and infections and how everything could start in the intestine ... in theory.

I quote:”Michael Schlossmacher of the Ottawa Hospital Research Institute, Canada, reported that the PD-linked gene LRRK2 helps mice fight bacterial and viral infections. Together with previous findings that animals release α-synuclein in response to infection, the data support the idea that microbial exposure could play a role in neurodegenerative disease. And if bad bacteria can hasten PD, could good bacteria delay it? A hint in this direction came from Roberto Grau of Rosario National University, Argentina, who reported that feeding probiotic bacteria to worms prevented α-synuclein accumulation and neurodegeneration. “

alzforum.org/news/conferenc...

[pvw2]

Another LRRK2 article:

New study may lead to better treatments for Parkinson's disease

news-medical.net/news/20200...