Certain probiotics for cognitive Health in Alzheimer's would it also help Parkinsons?

[parkie13]

articles.mercola.com/sites/...

Another interesting article. Supported by a study.

[rescuema]

I'm not a fan of mega dosing probiotics on a healthy individual eating clean balanced diet. The strains are limited in numbers and most of the marketed probiotic strains are transient. Unfortunately most people's gut biomes are compromised these days thanks to the ubiquitous toxins such as glyphosate and end up with overpopulation of resistant pathogens such as candida, c diff, salmonella, etc. that steal critical nutrients including thiamine. This is what most scientists had missed - they assumed glyphosate is safe for animals concentrating myopically on shikimate pathyway, but didn't take into an account the devastation it can cause on microbiome that live in our guts providing symbiotic relationship along with the loss of critical minerals. If your health is already compromised, good probiotics can certainly assist in the recovery especially after antibiotics treatment, but you most certainly must concentrate on eliminating toxins that caused the problem in the first place to find the natural sustainable balance.

[parkie13 in reply to rescuema]

So very true, our food situation in US is abysmal. I have taken probiotics in a limited Supply and limited time. I've been wary about changing my biome.

[rescuema in reply to parkie13]

One of the most important diet change we can make is to remove sugar, refined foods/carbs, especially the glyphosate tainted non-organic products that's on all grocery shelves now, including high traces in popular cereals such as Cheerios.

[rescuema in reply to parkie13]

One more cautionary tale on a related note, a lady I know was infected with c-diff after a hospital visit and antibiotics treatment. She tried multiple courses of the prescribed strong antibiotics along with very high dose of Florastor and all other available mega-dose probiotics but nothing worked and the resistant c-diff kept coming back continually. We were all seriously worried for her life until she ended up getting a fecal transplant from her husband out of state and THAT fixed the problem for good.

[aspergerian13 in reply to rescuema]

Also:

Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies.

ncbi.nlm.nih.gov/pmc/articl...

AND:

Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases.

by Anthony Samsel andStephanie Seneff.

mdpi.com/1099-4300/15/4/1416

[parkie13 in reply to aspergerian13]

Well, that explains it all.

The correlation between autism, Alzheimer's, PD, seizures, celiac , prion disease and many other diseases and the increase in their occurrence correlates with the ever-higher use of Roundup.

Our government and the big business is just laughing in our faces. The government institutions that have the power to test and limit the use of Roundup are doing completely nothing.

We are getting ever higher exposure to round up. As the article said the Roundup combined with other chemicals is 125 times more toxic then just plain glyphosate.

The horrible irony, and the joke is on us, since we need manganese at the same time it accumulates in the brainstem.

This should be shouted from the rooftops but I don't think that the doctors are even aware of it. They are definitely aware of Manganese as an agent that can cause Parkinson's. This is a very sad time in our human history.

[aspergerian13 in reply to parkie13]

Well expressed summary!

[rescuema in reply to parkie13]

Don't overlook iodine. If you're deficient as many are nowadays, the toxic metals and halogens can build up in the body as well as the ever growing thyroid diseases.

[aspergerian13 in reply to rescuema]

For more about shikimate effects :Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance.

ncbi.nlm.nih.gov/pmc/articl...

[John_morris71]

I am no expert (or a doctor), but have my thoughts on the probiotics. Sincerely believe that you need to take not the same probiotic everyday (that have the same culture or microbes) but to have an assorted type ( so that you have various bacteria - each helping in its own unique way, even though slightly different). Hence, better to have

KEFIR, (Lifeway brand has 12 live cultures, namely B. breve, B. Lactis, B. Longum, L. Acidophilus, L. Casie, L. Cremoris, L. Lactis, L. Plantarum, L. Reuteri, L. Rhamnous, S. Diacetlactis, S. Florentinus)

KOMBUCHA, ( culture is a symbiotic culture of bacteria and yeast - also many varieties of Kombucha too),

YAKULT (primarily has Lactobacillus casei strain Shirota),

SYMPROVE ( has 4 namely strains, L. rhamnosus, E. faecium, L. acidophilus, and L. plantarum along with extract of germinated barley).

Moreover, eating lot of fiber - (vegetables and whole grains) is like feeding these bacteria (present in the probiotics), the right fuel to help them churn any SCFA - Short Chain Fatty Acid - Butyrate that are helpful in many many ways to both the body, intestinal level and even the brain - thanks to the brain gut axis. Make sure that the probiotics have less sugar - they will surely have some to help the live cultures thrive.

Anyhow, before taking probiotics, better to do some research, talk to your doctor and go slow and steady ass you build up intake and variety. Taken over a long period of time, say 6 months to a year it has helped in matters regarding mood (better), bowel movement (easier), and yes even sleep pattern (longer peaceful, deep sleep) in my mother's case.

There are a myriad articles/publications - below is a sample.

ncbi.nlm.nih.gov/pmc/articl...

[chartist]

This study had some very good results even in this difficult study population and overall it shows great potential for AD!

One problem with this study (the 60 patient study) is that they chose to use AD patients who were at a very advanced disease state and potentially "beyond the point of no return". What might the results have been had they used AD patients in the mild to moderate range?

One more problem is that the high dose probiotic milk that they used did not contain even small amounts of prebiotics and prebiotics are fairly well established as potentiating the effects of probiotics as well as interacting with existing gut bacteria to produce short chain fatty acids of which one very important one is butyrate and butyrate is highly antiinflammatory and would be additive to the already potent antiinflammatory results they got with just the probiotic milk. Butyrate can also increase T-regulatory cells(Tregs) which are also antiinflammatory in their ability to turn down the inflammatory response itself.

Another problem is that the study was only 12 weeks long which is a really short study period for a disease of this nature and in general shorter than many other AD studies. A longer study period could have shown if the results were cumulative and continued to increase over a longer study period. If that were to turn out to be the case, this study would be of very huge significance as that would mean that the probiotics alone are doing more than the currently available prescription meds can do for AD.

One can only imagine what might have happened in a "12 month study" instead of just a 12 week study, that also included a prebiotic (to form a synbiotic) and if they had used patients that were mild to moderate instead of severe, in terms of disease status! The possibilities seem quite compelling! Unfortunately, that study that was published in 2016, has had no follow up studies to confirm their results and to see if a longer study period, the addition of prebiotics, and patients of lesser disease status could have further improved upon their impressive results!

Art

[parkie13 in reply to chartist]

I agree.

[John_morris71 in reply to chartist]

We can try it out by ourselves for a few months and extend it for an year or more, choosing to continue, especially if it is beneficial. At least we have the info and theory associated with it. Imagine not having the internet as a resource and trying to find out/search anything that can be potentially useful. Trying to stay positive (even though at times it is a challenge).

[chartist in reply to John_morris71]

John,

Often times we are left to our own devices and trial and error. We often have to count on the safety profile of whatever we are considering to use as the basis for whether we test it or not. Studies would be much more helpful, but those are often lacking when it comes to alternative supplements. That is our reality.

Art

[Despe in reply to chartist]

Morning Art,

I would like to add a Prebiotic to my husband's Probiotic (Mary Ruth), but I am not sure what would that be. Any good Prebiotic in mind? Thank you.

[chartist in reply to Despe]

Well, if he happens to be taking mannitol, that is a good prebiotic as is xylitol.Many of the other sugar alcohols that end in tol are prebiotics. Potato starch is also a very popular one, but I can tell you that that one gives you so much gas it is just ridiculous, but I imagine that that is related to butyrate production also, which is a very good thing. Probiotic manufacturers often use fructooligosaccharides (FOS) as their main prebiotic and also Galacto-oligosaccharides (GOS) and sometimes both FOS and GOS . Not sure why they choose those two, but cost is probably a factor. Generally speaking. these small capsules deliver relatively small amounts of prebiotics, so additional prebiotic may be needed in order to get the most from your probiotic or synbiotic. Many things we eat or might eat are also considered prebiotics. Here is a list of some common ones :

1. Flaxseeds

2. Dandelion Greens

3. Jerusalem Artichoke

4. Garlic

5. Onions

6. Leeks

7. Asparagus

8. Bananas

9. Apples

10. Cocoa

11. Wheat Bran

12. Seaweed

Art

[parkie13 in reply to chartist]

natural-digestion.com/prebi...

Another good one are beans and legumes.

[Despe in reply to parkie13]

Yes, we eat plenty of legumes. We have been on Mediterranean diet all of our lives and legumes is a big part of it.

[Despe in reply to chartist]

Yes, he is on Mannitol and loves apples and bananas which he eats every day.