B1 and stopping Antidepressants.

[38yroldmale]

Diagnosed Dec 2018. On B1 since March 2019. Varied from 1-4 grams. Kept lowering my dose over time until July 2019 found my ideal dose was 1 gram. Did great for some time. Continued to improve, at the same time I weened off my antidepressant I had taken for 15 years. For a 2-3 weeks I almost forgot I had Parkinson’s. Then worsening of symptoms. I didn’t realize it might has been B1 causing it. I took 2 days off B1 and have began to improve. I was on my 1 gram dose for a long time. I thought once you found your dose you would continue for good? Could it be something to do with my antidepressant? I even looked into a drug induced Parkinson’s for a time during that 2-3 weeks because I felt so well.? How long should I take a break from B1. Should I then start at 500 mg?

I know SSRI antidepressants are proven to go to the exact place Parkinson’s starts. My symptoms seem to have improved more by removing the antidepressant than anything else? For the lack of antidepressant caused a lowering A needed lowering of b1?

[chartist]

38yroldmale,

You may have missed several recent post replies I made on this subject, but many forum members who have been on HDT for months are starting to report similar to you at 6 to 18 months of HDT use. As you have already seen, a brief stoppage of your dose for two days showed you a reduction of the symptoms increase that you noticed, which is what other members are also seeing.

Dr. Costantini's two answers to this problem are to take a break of about a week and restart at the same dose , but to skip one or two days of HDT during the week to create a relatively small dose reduction. His other answer to this problem was to take an HDT mini vacation for a few days to a week or even more every three months or so.

The reason for this phenomenon, according to Dr. Costantini's theory is that a reduction of neuroinflammation, neurodegeneration and oxidative stress in the brain caused by regular use of HDT can result in cellular repair in the brain. This cellular repair results in a decreased demand for B-1 which in turn creates a surplus of thiamine and too much thiamine results in increased PD symptoms. This is a B-1 overdose situation and the above is Dr. C's answers to this problem! My guess, for the reason that the time frame varies from 6 to 18 months may be due to how much cellular damage there is when you start on HDT. More damage may take longer to repair, but once enough cellular repair has taken place, the demand for B-1 may decline. If Dr. C is correct in his theory, then it is conceivable that this could happen again somewhere down the line in time.

Art

[38yroldmale]

Thanks Art!! That makes perfect sense. Being newly diagnosed, I started pretty early In comparison to others. My damage to my brain is probably a lot less than those who have had Parkinson’s for longer.I don’t want to say it, but does that mean healing is taking place? Is that what you meant?

[chartist in reply to 38yroldmale]

You have to remember that this is only Dr. Costantini's theory, but if he is correct about the cellular repair, then that is a form of healing. His theory was that this cellular repair was only healing what is repairable that has been damaged by part of the disease process. Repairing the damage, though is not stopping the disease itself, but apparently can slow or halt the disease progression so far in Dr. C's 7 years of clinical experience with his Parkinson's/ HDT patients.

Art

[rescuema]

If you're not already, be sure to take an increased dosage of well-balanced b-complex (methyl Bs better), a good multivitamin, and Magnesium along with thiamine therapy. Read this article for another possible explanation.

hormonesmatter.com/back-pai...