Why Mouse brain studies come up short for humans.

[jackedmonston]

Subtle Differences In Brain Cells Hint at Why Many Drugs Help Mice But Not People

Heard this story on NPR this AM

[park_bear]

There is a very basic reason why most mouse brain studies are very poor predictors of what will help humans with Parkinson's: they check whether a substance will protect the mouse against an artificially induced form of parkinsonism. This quite a bit different from whether a substance will help a human, or even a mouse, recover from Parkinson's.

[felixned in reply to park_bear]

Right, pb. Some illnesses can be treated without knowing what is causing them and mechanism behind their progression. PD obviously doesn't belong to that kind. I am afraid we'll be stuck with palliative treatment until we understand the etiology of the disease, and understand what really is driving its progression.

[Rhyothemis]

link to research article

pubmed.ncbi.nlm.nih.gov/314...