It seems like L-carnosine, a natural molecule of the brain, may have some significant benefits for PWP:
Following is the relevant quotation from self hacked.com:
10) May Treat Parkinson’s Disease
Carnosine reduces the formation and promotes the breakdown, of abnormal proteins that are a cause of Parkinson’s .
It is thought that mitochondrial dysfunction as a result of oxidative damage plays an important role in Parkinson’s. Carnosine has been shown to suppress the type of oxidative damage linked to Parkinson’s .
MPTP is a neurotoxin that induces symptoms akin to Parkinson’s (short-term tremor, weight loss, rigidity, etc.). One study found that, in animals, Carnosine (100mg/kg for 14 days) decreased the severity of MPTP-induced symptoms. This corresponded with lower levels of lipid hydroperoxides and MAOB activity in their brains .
Studies have shown that patients with Parkinson’s often have damaged glyceraldehyde dehydrogenase, an important enzyme found in the frontal cortex of the brain. This damage leads to decreased ATP production and increased production of the highly toxic agent, methylglyoxal. Carnosine protects against damage to the glyceraldehyde dehydrogenase enzyme .
Carnosine promotes protein balance by decreasing methylglyoxal, which is often raised in those with Parkinson’s .
The brain’s substantia nigra, the section where dopamine is made, is prone to reaction with methylglyoxal, especially in the presence of high blood sugar. This harmful reaction, which makes ACTIQ, is prevented by Carnosine .
Carnosine inhibits malondialdehyde (MDA) toxicity in neuronal cells and limits the formation of protein carbonyls and protein cross-linking associated with Parkinson’s .
L-dopa is often used as a way to maintain dopamine levels in Parkinson’s sufferers. Unfortunately, some of the by-products of L-dopa are neurotoxic (e.g. those containing aldehyde groups). Carnosine neutralizes these toxic compounds and, therefore, is probably a fantastic supplement to combine with L-dopa therapy .
In fact, one study showed that a combination of L-dopa and Carnosine treatment (1.5 g/day) improved a number of neurological symptoms, such as rigidity of the hands and legs, and increased hand movement and leg agility. This corresponded to a decrease in protein carbonyls in the blood .