This is a small study - only 7 people. However, P = .007 shows the results in this group were highly significant. I put more stock in a study like this than a big study that barely meets P <.05.
amjmed.com/article/S0002-93...
Abstract
Background
Multiple-system atrophy is a neurologic disorder characterized by orthostatic hypotension, Parkinsonian signs, and cerebellar signs. Mutations in COQ2, an enzyme involved in coenzyme Q10 synthesis, were recently associated with familial and sporadic cases of multiple-system atrophy. I hypothesized that people with orthostatic hypotension with or without other symptoms of multiple-system atrophy might benefit from oral coenzyme Q10 administration.
Methods
Seven patients with symptomatic orthostatic hypotension were treated in an unrandomized manner with 257 ± 37 mg coenzyme Q10 daily for 10 ± 3 months.
Results
Before starting coenzyme Q10, patients' systolic blood pressure fell 30 ± 4 mm Hg upon standing from a sitting position. After treatment with coenzyme Q10, their systolic blood pressure decreased 7 ± 5 mm Hg upon standing from a sitting position (P = .007 for change in systolic blood pressure decrease by paired t test).
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Note that the threshold for a finding of orthostatic hypotension is a fall in systolic blood pressure of 20 points or more. So at the end of the study these patients would be regarded as not having orthostatic hypotension.
