Another Reason to Take B12

[jimcaster]

In summary, VB12 can efficiently disassemble mature [alpha-synuclein] fibrils and protect [nerve] cells from [alpha-synuclein]-induced toxicity,” the researchers wrote

parkinsonsnewstoday.com/201...

[jimcaster]

Of all the supplements and vitamins I take, none of them made me feel IMMEDIATELY better like the methylated multi B vitamins with a very high dose of B12. It's impossible to describe, but I immediately felt better. I take something like 500 times the recommended daily allowance of B12...and an even higher amount of B1. I'm curious to know if anyone else had a similar experience.

[Gioc in reply to jimcaster]

Jim, excuse me ,but what’s exactly this multi b vitamins?

[jimcaster in reply to Gioc]

Capsules containing B6, and B12 among others.

[Gioc in reply to jimcaster]

thank you, I thought it was a brand of b complex on the market that I could buy.

[ConnieD in reply to jimcaster]

How much b12 and what brand do you take? I just started methylated b12 but not in a B complex. Thanks Connie

[jimcaster in reply to ConnieD]

Apex Energetics. Methyl-SP™

apexenergetics.com/methyl-sp

[Stevenmast in reply to jimcaster]

Thank you! Isn't there a concern with taking b6 with l-dopa?

[LAJ12345 in reply to Stevenmast]

The problem is the carbidopa in sinemet etc degrades b6 but b6 is essential for many enzyme processes. They say b6 degrades carbidopa and it does, that’s why they say not to take it but b6 is essential for your body, carbidopa isn’t!

Take it away from anything containing carbidopa and it should help.

[Stevenmast in reply to LAJ12345]

thank you! I'm only taking mucuna no Carbidopa so I guess I'm good.

[Kia17 in reply to jimcaster]

Hi Jim

What B Vitamins brand are you taking?

[jimcaster in reply to Kia17]

See above.

[ConnieD in reply to jimcaster]

I’ve not tried this product but i remember reading that someone on HU with mthfr (which I have) they also had high homocysteine levels were advised to take methylated vitamins with trimethylglycine. He felt better. The product your taking has that in it, I wonder if that’s helping you at all.

[jimcaster in reply to ConnieD]

Very much so. I've had blood tests every 3 months and my homocysteine levels dropped quite substantially after I began taking this.

[ConnieD in reply to jimcaster]

That’s very interesting to me, do you take it as per directions on the bottle? Do you take any additional b vitamins separately? I should get my levels checked too!

[jimcaster in reply to ConnieD]

I take 4 capsules per day. I also take 1.5 grams of B1 per day...sometimes just 1 gram of B1.

[ConnieD in reply to jimcaster]

Thanks for the information Jim! I need to look into this!!😊 Glad to hear it’s helping you!!

[ElliotGreen in reply to ConnieD]

Hi there Connie. How did you find out that you have mthfr? What kind of genetic test did you get?

[ConnieD in reply to ElliotGreen]

I found out over 10 years ago since I had high risk pregnancies. My Dr just ordered a blood test. I only know from what she said that I tested positive to only one copy of the gene. Had I tested positive to 2 copies I would have taken heparin injections which I did for all but my last pregnancy. I still took prescription methyl folate but that Was it and baby aspirin for a time. The mthfr test was not available before that from what I was told.

[KERRINGTON in reply to jimcaster]

2 capsules = 680 mcg B12..is that the equivalent of 128,000 rec daily allowance ? I take 6,000 mcg, Live Wise drops, and it barley helps me.

[jimcaster in reply to KERRINGTON]

I was wrong about that. According to the label, two capsules are 250 times the recommended value. I take four capsules daily, so I'm taking 500 times the recommended amount.

[ElliotGreen in reply to jimcaster]

2400 µg of vitamin B12 is equivalent to 50,000% NRV (nutrient reference value). So that is 500 times the conventional recommended amount.

[Janice557799 in reply to jimcaster]

B-12 injections have much greater uptake of the vitamin. Doctors will give scripts for the B-12 fluid and the needles. I have given B-12 injections for years (Had bowel surgery as a teen and need shots for life)... the shot is best. But you will get some B-12 into your system sublingual style. Good fortune to all.

[MWLE in reply to Janice557799]

Hi Janice - what is the amount of B12 injections you are taking and how often?

I started my Uncle and father on that about 3 weeks ago 2 x a week. Not sure what the best dosage and frequency is.

Thank you,

Mon

[Janice557799 in reply to MWLE]

I take 1 1/2 ml .. 2 times per month. We just started my brother in law (who has advancing Parkinsons) and hope to see some results very soon. You need a 25 gauge needle and 1" .. this needle gets into a muscle which is necessary for B-12 to get into your system. With my Brother-in-law I am giving 2 ml every time I see him or about 1 time each month. If I could see him more often (they live in another town) I'd give him one injection per week. When one is depleted, rapid therapy is needs i.e., 1 ml per day for the 1st week, then taper off to 1 ml every 2 days etc. With the best result being maintenance at 1 or 2 shots per month of 1 1/2 or 2 ml each month. questions? feel free as I've been at this for years.

[Janice557799 in reply to Janice557799]

one more thing: according to Docs, Pharmacists, and research... a person cannot overdose on B-12. Your body just stores it in your liver and releases it as needed. Best results to keep your B-12 on board is to avoid too many sugary foods as sugar depletes your store of B-12 gradually.

[MWLE in reply to Janice557799]

Thank you Janice. I have been doing .1 ml two times a week for my father and .2 ml for my uncle. I will increase that.

[Janice557799 in reply to MWLE]

yes depending on their needs and if you just started them on B-12.. a larger dose might be fast to get them caught up... your or their doctor might help with the dose but keep in mind docs don't usually think too much about vitamins. I hope it all comes as a big help for them... The goal is to just give an injection once per month if under age 50 and 2 times per month if over age 50.

[Janice557799 in reply to MWLE]

sorry, I have been very busy and gone a while. My brother in law is presently only taking sublingual B-12 and refused the injection (which gives very good results). I still recommend about 1 cc every week for a while, maybe 2 months, and then back off to about 1 cc every 2 weeks until the results are better... better balance for one thing. We have been kept busy taking care of 2 people off and on... one with PK and one with Alzheimer's which also requires some B-12 therapy.

[ElliotGreen in reply to Janice557799]

Consider sublingual vitamin B12.

There are doctors who specialize in Chronic Fatigue Syndrome who recommend that their patients take vitamin B12. I've seen one Dr. recommend SUBLINGUAL vitamin B12, as it is absorbed better than oral B12, and isn't as expensive or painful (or so much of a hassle) as injections.

[ElliotGreen in reply to jimcaster]

Hey Jim, I think you're off by a factor of 100.

2400 µg of vitamin B12 is equivalent to 50,000% NRV (nutrient reference value). Notice the percent sign. So you're taking about 500 times the conventional recommended amount.

[Kia17]

“A certain percentage of the population – possibly as high as 30% – is unable to metabolize the unmethylated forms of specific B vitamins, namely Folate and Vitamin B12. The active forms of these B vitamins are referred to as the methylated form. This is the form that your body can actually utilize.”

[ConnieD]

Thanks whenever you can, thanks

[Gioc]

Thank you!

[ConnieD]

Thank you!!

[jimcaster in reply to ConnieD]

You're welcome! Ingredients and more info are on the link below.

[BUZZ1397]

👍Great post

[Millbrook]

Coincidentally I just started my husband on VB12 a week ago. He takes the Solgar sublingual Methylcobalamin 1000 mcg

[Toogood]

Does it help with tremors

[jimcaster in reply to Toogood]

Not that I am aware of, but I don't have any resting tremors.

[LAJ12345]

Hardy’s DEN has all the methylated b vitamins in it which is probably one reason why it makes you feel good.

If you take a b multi be sure to take the natural methylated forms not cyano cobalamin or folic acid which will make you worse if you have certain methylation gene defects.

[PDConscience]

FYI It appears to be priced more reasonably on Amazon: amazon.com/Apex-Energetics-...

[PDGal4]

If I am calculating correctly, 4 capsules x 600 mcg, so 2400 mcg daily? I had B12 shots for 2-3 years following PD diagnosis and extremely low b12 levels shown on blood test. Off shots, but take average 2000 mcg daily, either sublingual or chewable, as prescribed by doctor at the time. Helps with energy level. Have levels tested yearly very easy blood test. Heartened to read this latest research.

[Millbrook in reply to PDGal4]

Actually according to the label 2 capsules give 600 mcg. So 4 capsules wd be 1200 mcg. How much VB12 should we be taking so that we do not overdose

[jimcaster in reply to Millbrook]

I found this info on Healthline:

Since B12 is a water-soluble vitamin, it’s generally considered safe, even at high doses.

No Tolerable Upper Intake Level (UL) has been established for B12, due to its low level of toxicity. UL refers to the maximum daily dose of a vitamin unlikely to cause adverse side effects in the general population.

This threshold has not been set for B12 because your body excretes whatever it doesn't use through your urine.

[Millbrook in reply to jimcaster]

But would having large doses of different things exert pressure on the kidneys?

My supplement list gets longer

[jimcaster in reply to Millbrook]

I don't know. I share your dilemma regarding a long list of supplements. It's overwhelming sometimes, but I try to do a cost-potential benefit analysis for each supplement and the B vitamins seem to have little risk/cost and potentially high rewards.

[PDGal4 in reply to jimcaster]

Dr Constantine, when I emailed him, suggested I come off the B12 as my blood level is good now and he said I could monitor it. My neurologist suggested same thing last visit as I had some mild tingling in my right foot climbing up my calf, which he said could be a side effect of B12. I've decided to stay on it. It's been working well for me for 7+ years and I'm of the mindset "if it's not broke, don't fix it." I did cut down to 1000 mcg from 2000 mcg for a few days until tingling disappeared. I've taken up to 4000 to 6000 mcg at times, but am settling in at 2000 mcg for a while. I have been more fatigued lately, so I may up B12 in a few days if fatigue doesn't lift to see if it helps.

[KERRINGTON in reply to PDGal4]

Years ago ( 60's ), my mother got B12/B1 shots monthly, 50,000 units. They gave her, her life back.

[LindaP50]

Good info. Thanks for sharing. My husband has Lyme Disease and PD - with extensive blood work done learned his body didn't absorb Vit B - and was prescribed to take Active B-complex with quatrefolic brand Methylfolate- He's been taking only 1 capsule daily although serving is 2 capsules daily. After reading the article we'll be adjusting this to 2 capsules daily.

[Springfield78]

Very helpful information! Thank you!

[Oceanflow]

Thanks for your post.Great info.

[ElliotGreen]

It would be great to see if these findings persist in research in live animals or humans. (The experiments reported in this article were done in test tubes.)

[Janice557799]

I'm still here and all those I help with B-12 injections are still doing well. The only change I can suggest is to take ALL the B vitamins to be sure that you are not out of balance. If taking more of one of the B vits, your other B vits may be out of balance... so a good multiple B may be in order. There is so substitute for B-12 absorption however, that can do as well as an injection of B-12.