Amantadine or Mirapex?? I’ve noticed that my C/L 25/100 is only lasting 2hrs afterwards am like in slow motion....

[Chicafromchitown]

But by the time it kicks in (1hr) am left with basically 1hr 1/2 and noticed that right hand tremor is more dominant now, I wanted to know if just taking c/l is enough for someone who has been with Pd for 10yrs? I was taking mirapex 1tab 3x/day for almost 8 months then I stopped taking them. On my last visit to my neurologist she said I had a lot dyskinesia so she added amantadine. I don’t want to take DA’s but if one of them is going to help with tremor I will take it. If anyone that’s on any of this meds and is helping please share your experience. Thank you 😊

[Cbgs]

Once that began happening to me

I began the ext release C/L

Now I take an ext rls every 4 hours and a quarter of the immediate rls every two hours: this regime has dramatically reduced the severity of on & off periods

It has leveled me out

I take amantadine 3x per day which has helped with dyskinesia

Hope that helps

Be well

C!

[park_bear in reply to Cbgs]

I second the recommendation for extended release /controlled-release / sustained-release C/L.

[Chicafromchitown in reply to park_bear]

I wii contact my neurologist to make the switch, she also mentioned Rytary is that the same as c/l?

[park_bear in reply to Chicafromchitown]

Rytary is an extended release form of carbidopa/levodopa, a good candidate.

[Chicafromchitown in reply to Cbgs]

Thank you

[Hidden]

Stay away from Mirapex. Can have Very nasty side effects! Do extensive research before even considering Mirapex.

[shelly9]

I am in similar situation. I was combining IR and CR Sinemet. I started Rytary and am having mixed results. Would like to know reasons people left Rytary and returned to Sinemet

[Stan-Dathwart]

I'm from greater Chicagoland myself - Schaumburg to be specific. Not there now though. I had it as bad or worse than you. No medicine other than IR and CR Sinemet worked. DBS didn't work. I went with DUOPA. The tightly-controlled, constant dosing has given me half of my previous life back, and I am continuing to keep a very mild positive traction going. Once my sleep got more normal, other systems came on line. After 6 months on this, I am slowly emerging into something I recognize as normal. Soon I will tackle my chronic lyme and many other tweaks are in the works. Some people respond much more quickly to the therapy. Incidentally, I believe the Sinemet is more effective as I have begun to identify various sources of anxiety and get them under control. I give DUOPA a thumbs up.

[shelly9 in reply to Stan-Dathwart]

Glad to hear you are doing better with Duodopa. Wondering what your dosage was with Sinemet before going to Duodopa. ? Also did you try Rytary ?

[Stan-Dathwart in reply to shelly9]

Daily: 15 x 1 IR + 2-3 ER for sleep Rytary did not work. Amantidine did nothing. Pramipexole made me dyskinetic w/ very low blood pressure. ALL foods had a dramatic impact. Duodopa fixed this very nicely!

[Jebbie12]

I have also had Parkinson’s 10 years. I take CL as well as selegiline, entacapone, Mirapex, and recently added one amantadine. My dyskinesia has improved, but still have an occasional off Times. I have had no issues with Mirapex and have been on it for eight years. You should closely monitor yourself and effects if you do go on it There’s no getting around the fact that we need to take more meds as time goes on if we want to have a productive life. I recently got certified in yoga and I’m getting to teach yoga to others with Parkinson’s. I couldn’t do that without meds. Good luck

[Chicafromchitown in reply to Jebbie12]

Jebbie12

How often do you take mirapex?

[Ireneno]

I also have had PD for almost 10 years I was diagnosed at 45 yrs old . I take Stalevo every 4 hrs .75 mg mirapex at night and .35 mirapex in the am recently I have been having bad dyskinesias. So I switched to a neurologist that specializes in PD he prescribed Amantadene for the dyskinesias. Felt great for 7 months , then vascular side effect kicked in . My feet and hands swelled up like elephant paws. Took 5 weeks to be able to wear shoes again. These meds suck ! So I’m back to playing around with dosages eliminating mirapex in the am but stretching the dosage times leads to dystonia in my feet that are debilatating. Sorry I don’t have good news. I am ready to try HDT.

Good luck .... not everyone gets these side effects from the Amantadene

[Chicafromchitown in reply to Ireneno]

Ireneno

Are you planning on stopping mirapex? How do wean yourself off it?

[Jebbie12]

I take .5 twice a day, and 1/2 of that once a day