Trazodone for Parkinson’s: delays progression

Hi all, found this information about the benefits of Trazodone. It appears that new research shows that it can help slow progression.

scienceofparkinsons.com/201...

cureparkinsons.org.uk/news/...

cam.ac.uk/research/news/sci...

[WinnieThePoo]

Another click-bait title that doesn't really match the content. Simon, in the first link, explains trazadone is a candidate for drug repurposing trials based on some evidence in mice that it may slow neurodegeneration, but suggests it may not be a good PD candidate because it interferes with dopamine uptake.

[sleezy]

I would not take Trazadone because of its negative effect on motor function.

[JohnPepper]

I am always skeptical when I see the words CAN and POSSIBLY. If the product DOESdo something for Pd I a sure the articles would say DOES!

[MBAnderson]

Not quite.

Simon says, "The researchers concluded “that Trazodone may be effective in alleviating L-DOPA-induced dyskinesia and psychosis in Parkinson’s, but its deleterious effect on motor function is a concern and may limit its tolerability and usefulness in clinical settings”. and "In addition to these studies, there have been other case reports suggesting that Trazodone may actually cause Parkinson’s-like motor-related issues in the elderly."

Conclusion; "... but to date there has been limited investigations of it in models of Parkinson’s. The clinical data that we have available is mixed and suggestive that some caution is required..."

[bamboo1953]

There are plenty of studies of medications, nutrients, vitamins, etc. that claim to show promise regarding some aspect of PD based on experiments conducted with mice. But as far as I know, only humans get diagnosed with PD, not mice! Best to take these studies with a grain of salt.