Cerebrospinal fluid levels of thiamine in patients with Parkinson's disease. - levodopa effect.

[aspergerian13]

Oldie:

Cerebrospinal fluid levels of thiamine in patients with Parkinson's disease.

Jiménez-Jiménez FJ, et al. Neurosci Lett. 1999.

Thiamine is an essential cofactor for several important enzymes involved in brain oxidative metabolism, such as the alpha-ketoglutarate dehydrogenase complex (KGDHC), pyruvate-dehydrogenase complex, and transketolase.

The activity of KGDHC is decreased in the substantia nigra or patients with Parkinson's disease (PD). We measured cerebrospinal (CSF) levels of thiamine-diphosphate, thiamine-monophosphate, free thiamine, and total thiamine, using ion-pair reversed phase high performance liquid chromatography, in 24 PD patients and 40 matched controls.

The mean CSF levels of thiamine-derivatives did not differ significantly from those of controls, with the exception of lower CSF free thiamine levels in the PD-patient group.

PD patients under levodopa therapy had significantly higher CSF thiaminediphosphate and total thiamine than those not treated with this drug.

CSF thiamine levels were not correlated with age, age at onset, duration of the disease, scores of the Unified Parkinson Disease Rating Scale of the Hoehn and Yahr staging in the PD group.

These results suggest that low CSF free thiamine levels could be related with the risk for PD.

PMID 10471207

ncbi.nlm.nih.gov/m/pubmed/1...

[aspergerian13]

See also:

The Beneficial Role of Thiamine in Parkinson’s Disease: Preliminary Report | 2012 Luong | Journal of Neurology Research.

neurores.org/index.php/neur...

PDF available via Google and semantic scholar.

[aspergerian13 in reply to aspergerian13]

Another:

onlinelibrary.wiley.com/doi...

Correction: spelling is Lurong.

[Stebu]

Thank you for reporting this research and these studies. I find them very helpful. You are awesome.