Close Encounter Between Alpha-Synuclein and Mitochondria

[aspergerian]

Front Neurosci. 2018 Jun 7.

The Close Encounter Between Alpha-Synuclein and Mitochondria.

ncbi.nlm.nih.gov/pubmed/299...

[Rosenmu]

I have been listening to the Mitochondria Summit, anything I can glean to help my mitochondria

[aspergerian]

From the study:

the intriguing possibility that α-syn could be involved in the control of mitochondrial function both in physiological and pathological conditions. In favor of this, it has been shown that a fraction of cellular α-syn can selectively localize to mitochondrial sub-compartments upon specific stimuli, highlighting possible novel routes for α-syn action....

it has been shown that a fraction of cellular α-syn can selectively localize to mitochondrial sub-compartments upon specific stimuli, highlighting possible novel routes for α-syn action. A plethora of mitochondrial processes, including cytochrome c release, calcium homeostasis, control of mitochondrial membrane potential and ATP production, is directly influenced by α-syn. Eventually, α-syn localization within mitochondria may also account for its aggregation state, making the α-syn/mitochondria intimate relationship a potential key for the understanding of PD pathogenesis.