N-acetylglucosamine (GlcNAc) reduces alpha-synuclein aggregation

[NextStage]

"Treating cells with N-acetylglucosamine, a molecule in the hexosamine pathway, improved protein folding in the ER, rescued lysosomal function, and reduced alpha-synuclein aggregation."

The above quote is from the article

parkinsonsnewstoday.com/new...

that was posted about yesterday on Health Unlocked by jeffreyn.

I made this as a separate post to highlight GlcNAc. I think I'm going to add it to my stack.

[JCRO]

I’ve been planning on adding for a few months. This is a timely reminder, TY.

[park_bear]

Study can be found here: nature.com/articles/s41467-...

"In mice, GlcNAc crosses the blood brain barrier" reference: jneuroinflammation.biomedce...

Edit: Recommendation withdrawn due to unrealistic concentration used in cell culture study. See below.

[yyy2u in reply to park_bear]

Is this the same thing as GlcNAc?

bulksupplements.com/product...

[park_bear in reply to yyy2u]

yes

[drumhead in reply to park_bear]

What brand/type did you order?

[park_bear in reply to drumhead]

see below

[Buckholt in reply to park_bear]

PB do you remember this thread?

healthunlocked.com/cure-par...

[park_bear in reply to Buckholt]

Yes this has been brought to my attention. There is a conflict in research results and caution is in order. In any case I have withdrawn my recommendation due to an unrealistic concentration of GlcNAc used in the cell culture study. See additional comment below.

[Fed1000 in reply to park_bear]

Hi park bear, the study talks about high doses. How many grams do you think you take daily? Which brand did you order?

[park_bear in reply to Fed1000]

ncbi.nlm.nih.gov/pmc/articl...

"Our estimate of UDP-GlcNAc concentration in mouse brain tissue was 62 pmol/mg"

This is equivalent to .062 mM (millimolar concentration). UDP-GlcNAc is derived from GlcNAc. Regarding GlcNAc, The study states: " An exception to this correlation came from cells cultured in the presence of 1 mM GlcNAc. In order to examine the consequences of supraphysiological UDP-GlcNAc levels without GlcNAc supplementation", indicating that normal physiological concentrations of GlcNAc are less than 1mM.

The study at hand used a 10 mM in cell culture. Based on the above indicated physiological concentrations, this is unrealistic.

I ordered the Jarrow brand. If I follow through with this will be taking one 700 mg capsule twice a day. Note that there is conflicting research as to whether this is helpful or not.

[park_bear in reply to park_bear]

221.2078 g of N-Acetylglucosamine is one mole, so 1 G is 1/221 = .0045 mole, or 4.5 millimole (mM). Distribute this over the total volume of body water, approximately 42 liters in humans, and the resultant concentration of taking one gram of N-Acetylglucosamine is 4.5/42 ~= .1 mM. So to achieve 10 mM concentration a person would have to take 100 times that much, 100 G.

[MarkPrana in reply to park_bear]

Thanks park_bear, really helpful interpretation as always.

Based on this, is it a fair assumption that you chose not to follow through with your plan of taking one 700 mg capsule of the Jarrow supplement twice a day?

Thanks,

Mark

[park_bear in reply to MarkPrana]

Correct. I decided not to follow through on that idea.

[Fed1000 in reply to park_bear]

Thank you very much.

[jeffreyn]

See also this thread from a couple of years ago.

healthunlocked.com/cure-par...

[Boscoejean]

"What are the side effects of N acetylglucosamine?

Side effects that have been reported are mainly mild gastrointestinal complaints such as heartburn, epigastric distress and diarrhea. No allergic reactions have been reported including sulfa-allergic reactions to glucosamine sulfate."

go.drugbank.com/drugs/DB00141

[Biscuit61]

is this the same as GlyNac

[NextStage in reply to Biscuit61]

GlyNAC is Glycine and N-Acetylcysteine. GlcNAc is N-acetylglucosamine. So, not the same.

[Biscuit61 in reply to NextStage]

From what I can glean this appears to be a positive supplement for PD symptoms??

[Despe]

Hubby is on Neuro-NAC, vitacost.com/nutri-neuro-na... Is this what we are talking about? Thanks!