"Treating cells with N-acetylglucosamine, a molecule in the hexosamine pathway, improved protein folding in the ER, rescued lysosomal function, and reduced alpha-synuclein aggregation."
Yes this has been brought to my attention. There is a conflict in research results and caution is in order. In any case I have withdrawn my recommendation due to an unrealistic concentration of GlcNAc used in the cell culture study. See additional comment below.
"Our estimate of UDP-GlcNAc concentration in mouse brain tissue was 62 pmol/mg"
This is equivalent to .062 mM (millimolar concentration). UDP-GlcNAc is derived from GlcNAc. Regarding GlcNAc, The study states: " An exception to this correlation came from cells cultured in the presence of 1 mM GlcNAc. In order to examine the consequences of supraphysiological UDP-GlcNAc levels without GlcNAc supplementation", indicating that normal physiological concentrations of GlcNAc are less than 1mM.
The study at hand used a 10 mM in cell culture. Based on the above indicated physiological concentrations, this is unrealistic.
I ordered the Jarrow brand. If I follow through with this will be taking one 700 mg capsule twice a day. Note that there is conflicting research as to whether this is helpful or not.
221.2078 g of N-Acetylglucosamine is one mole, so 1 G is 1/221 = .0045 mole, or 4.5 millimole (mM). Distribute this over the total volume of body water, approximately 42 liters in humans, and the resultant concentration of taking one gram of N-Acetylglucosamine is 4.5/42 ~= .1 mM. So to achieve 10 mM concentration a person would have to take 100 times that much, 100 G.
"What are the side effects of N acetylglucosamine?
Side effects that have been reported are mainly mild gastrointestinal complaints such as heartburn, epigastric distress and diarrhea. No allergic reactions have been reported including sulfa-allergic reactions to glucosamine sulfate."
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