Is the answer for Parkinson disease already in the medicine cabinet?Unfortunately not

[Farooqji]

bit.ly/2B2WVbS

[ParlePark]

Bad link.

[Despe]

NSAIDS are anti-inflammatory, Parkinson's D is actually an inflammation of the brain, so it makes sense to take 1-2 Ibuprofen tablets a day after meals.

[park_bear in reply to Despe]

Right, and contrary to the title of the post, the study at the link shows ibuprofen usage reduces the risk of Parkinson's:

"Results: We identified 291 incident PD cases during 6 years of follow-up. Users of ibuprofen had a significantly lower PD risk than nonusers (relative risk [RR], adjusted for age, smoking, caffeine, and other covariates 0.62; 95% confidence interval [CI] 0.42–0.93; p = 0.02). There was a dose–response relationship between tablets of ibuprofen taken per week and PD risk (p trend = 0.01)."

[MBAnderson in reply to park_bear]

I wondered the same thing. If there is reason to believe we should be taking ibuprofen, why the, "unfortunately not?"

[Despe in reply to MBAnderson]

Marc, here is my question, when I was younger I suffered from severe headaches and I was taking 1,600mg of prescription ibuprofen. Of course, I was "curing" my headaches but I ruined my stomach lining and am now suffering from GERD. The headache pain nerves are in the brain and the ibuprofen cures the pain, why can't it be used for PD inflammation too?

[Farooqji in reply to Despe]

This is a way too much dose

[Despe in reply to Farooqji]

Tell me about it. I suffer the consequences now as I was diagnosed with GERD. No more meds though, just a couple of ACID SOOTHE chewable tablets before meals and am good.

[MBAnderson in reply to Despe]

It sounds like from your post your headaches have gone away?

I don't know much about ibuprofen except that it is an anti-inflammatory which may explain why there's a correlation with reduced PD frequency.

Here is a 4-year-old HU thread where PWP believe their PD plateaued because of long-term use of ibuprofen.

healthunlocked.com/parkinso...

1600 mg is too much, though.

[MBAnderson in reply to MBAnderson]

Have you ever tinkered with dietary factors for your headaches?

[Despe in reply to MBAnderson]

Marc, thanks for asking. I stopped taking ibuprofen long time ago! No more headaches, and for an occasional one I take Tylenol although I don't think it's any safer than ibuprofen. In sum, all MEDS have side effects. We have to weigh risks vs benefits, and if there is no abuse, I don't believe there will be problems.

I used to take MIDRIN, another subscription pain reliever, but they withdrew it as it contained narcotic substances and young addicts always found ways to get it. It was then when I started ibuprofen (800mg x2/day). It was that time of female hormone changes. . .

[Farooqji]

An interesting article on Wikipedia especially reference #67 , 68 and 69 regarding its effects on PD

en.m.wikipedia.org/wiki/Ibu...

[Hidden]

It depends very much on what you have in your medicine cabinet!! If you are diabetic and have exenatide in your medicine cabinet you may be fortunate. medium.com/parkinsons-uk/ex...

[Despe in reply to Hidden]

What about those who are not diabetics??

[Hidden in reply to Despe]

Research is continuously looking at the repurposing of existing drugs to see how they perform against PD and other illnesses.