Missing doses : I asked this question which... - Cure Parkinson's

Cure Parkinson's

26,583 members27,901 posts

Missing doses

Stevenmast profile image
16 Replies

I asked this question which might be seemingly stupid because I have gotten mixed answers on the subject. To me, it sometimes feels good to rid my brain of mucuna or any other l-dopa product and allow it to fend for itself, even though my PD symptoms would be more evident. My thinking is perhaps primitive but I feel the brain needs to try to fend for itself once in awhile. Any input on this subject would be appreciate it! Thanks Steven

Written by
Stevenmast profile image
Stevenmast
To view profiles and participate in discussions please or .
Read more about...
16 Replies
dadcor profile image
dadcor

I do exactly like what you say. No axiomas with this shi... disease. You may do whatever you feel is good and works for you.

Stevenmast profile image
Stevenmast in reply todadcor

My neurologist said the same thing. Well, not exactly the same. LOL

park_bear profile image
park_bear in reply toStevenmast

My experience with levodopa is I can change as necessary without any problem. However, this is not true for dopamine agonist medication which must be adjusted up or down slowly.

Juliegrace profile image
Juliegrace

I skip doses quite regularly according to how I feel or how taxing my day may or may not be. Some days I take as little as 200mg for the whole day and other days it might be 400mg. I do not take any meds at night so my last dose of the day might be at 4:30 pm or 6:00 pm.

Astra7 profile image
Astra7

I’m not sure. My understanding is that it’s best to deliver the body a constant stream of dopamine to avoid dyskinesia. My neuro said timing was important and another neuro told me we want the receptors to be ‘bathed ‘ in dopamine otherwise they give up.

That said I sometimes take my next dose early if I’m stressed or tired, and sometimes take an extra dose.

Stevenmast profile image
Stevenmast in reply toAstra7

Very interesting!

PDGal4 profile image
PDGal4 in reply toAstra7

My neurologist said the same thing--the body likes predictability of medication. I also take additional C/L between Rytary doses for wearing off, as needed, so I guess there can be some variability.

in reply toAstra7

Doc. Costantini says you may never get dyskinesia as long as you are on HDT.

Astra7 profile image
Astra7 in reply to

I think he might be right. In the past few months I’ve had a bit of dyskinesia, but have found 200mg of B1 a day seems to stop it. I’m trying to build up to 500 mg but I get very anxious and feel like I can’t breath. Might need to reduce my coffee intake to compensate. It’s all such a balancing act.

in reply toAstra7

Therapeutic level is 4g daily.

Astra7 profile image
Astra7 in reply to

People seem to be reporting improvement with less than that. Maybe it varies by individual or maybe the placebo effect bumps up the lower dose!

My pills are 100mg so I’d have to take 40!

rhyspeace12 profile image
rhyspeace12

If my husband takes his Sinemet irregularly, it causes wearing off and bad stomach pain. Then he sometimes gets panic attacks and can even become psychotic. He can get dyskinesia with too much dopamine, but it beats the stomach pain, so he has been advised to sometimes take a small extra dose in between doses.

LAJ12345 profile image
LAJ12345 in reply torhyspeace12

Sorry, do you mean the stomach pains are due to taking it irregularly or is it a side effect of the sinemet?

rhyspeace12 profile image
rhyspeace12

. When the Sinimet starts wearing off, it causes the stomach pain. Another dose of Sinemet will stop the pain oft times. If he gets real panicky over the pain, he makes it worse. So, the best thing to do is take it regularly and before it wears off. He can take it every three hours if the pain starts at the 4 hour point, which is the normal dose (taking it every 4 hours)Tthe doctor also gave him some low dose to take a single dose added to his Rytary (exended release Sinemet) in between, like at 2 hour timing.

HugoRipanykhazov profile image
HugoRipanykhazov

Why would you want to let the brain get on with doing things for itself when you have got a DEGENERATIVE brain disease? What would it achieve and how would you know if it was ameliorating anything before it would be too late to stop your experiment?

Stevenmast profile image
Stevenmast in reply toHugoRipanykhazov

Perhaps denial?

Not what you're looking for?

You may also like...

Is this a brain fog? How do I get rid of it?

I was diagnosed 2 years ago & primarily had movement issues. Now my brain itself seems to be the...
Nippermcc profile image

Gamma brain wave entrainment using sound and light at 40 Hz

Not really news - but news to me - is that there are/have been (very small) clinical trials on...
Rhyothemis profile image

The Brain That Changes Itself

THE BRAIN CAN CHANGE ITSELF About the Book… THE BRAIN CAN CHANGE ITSELF. It is a plastic, living...
Kia17 profile image

PTT trials for 50 participants at 8 locations* in the US. Out of nowhere. Bilateral will be offered if you qualify. (*Thank you Rebtar.)

Criteria Inclusion Criteria: Men and women, age 30 years and older, desiring bilateral treatment...
MBAnderson profile image

Long term use of large doses of ldopa. Any risks?

Kinda following on from my previous post about high concentration ldopa supplements. Several forum...

Moderation team

See all
CPT_Aleksandra profile image
CPT_AleksandraAdministrator
CPT_Anaya profile image
CPT_AnayaAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.