Baicalein for Parkinson : ... - Cure Parkinson's
Baicalein for Parkinson
So much interesting stuff. Especially once you start following links. This time I could just about hang on in there. Maybe because so much ended up returning to L-channel calcium and alpha-synuclein. There is clearly more to defeating PD than just poo - although I still champion that cause
iqbaliqbal thank you. I've been talking this herb (skullcap) for about a year now. This is smoother one i have added to my new list thanks to your research.
What other supplements do you take pls?
Damiana
Echinacea
Moringa
Cumin seed powder
Skullcap
Gotu Kola
Milk Thistle
Suma root
Tongkat Ali
Gingko
St Johns Wort
Astragalus
Burdock root
Ashwagandha
Olive leaf
Bocopa Moniere
Magnesium
L-Dopa 100% from mucuna seed
B1 high dose
Although it might sound like alot it's not. I order from Ameriherb.com by the pound and mix three scoops of each together in a container, mix well and take twice a day. This order has lasted all year.
I envy your efficiency!
Thanks f or the link, very informative. Sylvestris has posted about Baicalin. I take it every day, 250mg suspension in water. I buy online from a company called LiftMode. I guess weight lifters use it. $18 USD for 20g crushed powder, not bad. I've noticed no side effects.
Silvestrov , who was a member of HU but has since disappeared, suggested using this too . It’s such a shame he doesn’t post any more as he was soooo knowledgeable
Studies ncbi.nlm.nih.gov/pmc/articl... showed that Flavonoids with three or more vicinal hydroxyl (OH) groups exhibit potent inhibitory effects on α-synuclein fibrillation.
The flavonoids BAICAILEIN and SCUTELLAREIN (HP-6) include 3 vicinal hydroxyl (OH) groups. These are some of the most potent a-syn inhibitors in the nature able to almost completely, at least in-vitro studies, clear-up fibril formations and inhibit a-syn aggregation.
Other potent 3 vicinal-HO flavonoids include MYRICETIN, EGCG CATECHINS, TRICETIN, ERIODICTYOL ncbi.nlm.nih.gov/pmc/articl...
Flavonoids neuroprotective effects can be related
a) indirectly, to their ability to modulate cell-signaling pathways
b) directly, to the ability to bind and disintegrate a-syn protein aggregations
c) the antioxidant properties of flavonoids in combating oxidative stress by scavenging radicals and by metal chelation.
The study ncbi.nlm.nih.gov/pubmed/257... quotes the following:
“Flavone derivatives as inhibitors of insulin amyloid-like fibril formation.” Examining the data from all 265 flavones we confirmed previous observations that identified the importance of hydroxyl groups for inhibition. Our evidence suggests the importance of hydroxyl groups at locations 5, 6, 7, and 4', and the absence of a hydroxyl group at location 3, for inhibiting amyloid formation.
What makes the flavonoids Baicailein and Scutellarein such superior inhibitors of fibril formations?
Baicalein includes OH-groups on positions 5,6,7 and Scutellarein includes 5, 6, 7, and 4'. Those flavonoids are some of the most potent a-syn inhibitors screened so far.
Specifically, Baicailein proved in inhibiting a-syn fibrils in multiple rodent studies.
A) [Protective effect of baicalin on mouse with Parkinson's disease induced by MPTP]. ncbi.nlm.nih.gov/pubmed/181... "The preventive medication of baicalin shows a protective effect on C57 BL mouse with Parkinson's disease induced by MPTP. "
B) Therapeutic effects of baicalein on rotenone-induced Parkinson’s disease through protecting mitochondrial function and biogenesis ncbi.nlm.nih.gov/pmc/articl..., our findings indicated that baicalein exerts therapeutic effects partially through the activation of the CREB/GSK-3β/PGC-1α pathway to enhance mitobiogenesis and subsequently improve mitochondrial function."
C) Baicalein inhibits α-synuclein oligomer formation and prevents progression of α-synuclein accumulation in a rotenone mouse model of Parkinson's disease. ncbi.nlm.nih.gov/pubmed/274... "These results suggest that Baicalein could prevent the progression of α-syn accumulation in PD mouse model partly by inhibiting the formation of the α-syn oligomers."
D) Baicalein significantly attenuated muscle tremor of PD rats. The metabolic balance between GLu and GABA was modulated by baicalein treatment. These results suggest that baicalein plays a neuromodulatory role in balancing GABA and GLu neurotransmitter in basal ganglia, and might be a promising candidate for the treatment of tremor-dominant type of idiopathic Parkinson's disease. ncbi.nlm.nih.gov/pubmed/288...
Safety Profile:
Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers.
ncbi.nlm.nih.gov/pubmed/252...
"Dosing regimens were 200, 400, and 800 mg once daily on days 1 and 10, twice daily on days 3-9. Thirty-three of 36 enrolled participants completed the study. A total of 44 adverse events occurred in 23 participants. A steady-state concentration of analytes in plasma was achieved on day 8 after repeated dosing. In dose range of 200-800 mg, multiple-dose oral baicalein administration was safe and well tolerated, dose proportionality was inconclusive, and no serious accumulation of baicalein was observed."
Baicalein, is a potent natural neuroprotective agent, currently under research for the treatment of Parkinson's disease. The safety profile of Baicalein is based on short-term human studies. Some animal studies, however, show that high doses of Baicalein may induce a toxic effect ncbi.nlm.nih.gov/pubmed/288.... At this stage, I would suggest anyone supplementing with Baicailin to be cautious with dosage and administration.
hi Greenday,
Always a pleasure to read your posts,
I'd like to hear your opinion on vinpocetine, if you don't mind me asking.
Thank you in advance.
gio
I used to use Skullcap as a fairly potent anti-inflammatory, but it eventually started to bother my stomach and gave me diarrhea or loose stools after months of use. I ended up switching to the AKBA form of boswellic acid extract which had similar anti-inflammatory effects. I am no longer taking that and am now using EGCG extract from green tea in combination with pine bark extract which I find to be useful for lowering inflammation. The egcg can be a little risky for some people who's liver does not seem to be too tolerant.
Art
You’ve been through them all (except curcumin)? How does one know if it’s working on inflammation: less pain especially in joints, I presume? And if not pain - working At cellular level: check your serum for reactive pro +creatinine or similar (forgot the marker)
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