A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux

[stepan13]

An anti-seizure drug (and probably many more) is more effective when administered at night

cell.com/cell/fulltext/S009...

[Lana666]

Do you have access to the full paper?

[stepan13 in reply to Lana666]

No, but I read summary in Russian chemrar.ru/u-mozga-nashli-c...

[Lana666 in reply to stepan13]

Thanks for the link. Though it's still the summary. I was curious what drug(s) did they try. It's a little bit more specific in the Russian abstract "anti-epileptic" vs "anti-seizure". The last sentence of the abstract generalize it "for drugs targeted to the central nervous system". I guess it may work for many supplements that we discuss here which have low bio-availability due to BBB crossing limitation.

[stepan13 in reply to Lana666]

"it may work for many supplements that we discuss here"

This is the reason why I shared the link

[GymBag]

That picture of a mosquito . It would make sense that the brain would keep out anything during a time period when higher probability of mosquito contact would occur and open to be more receptive when it is safer. Very interesting thanks for posting. Are you in Russia now?

[stepan13 in reply to GymBag]

I am in Mexico till the end of the month. After that I am in NYC