I wonder if anyone can help. I completely accept that this might be a silly question but I am asking it anyway.
When we say that a supplement has properties that help vitamins/ minerals cross the blood/ brain barrier, are we altering the properties of the vitamins/ minerals or are we altering the way the the blood / brain barrier works?
Can you give an example of a supplement which helps vitamins and minerals cross the blood brain barrier?
It means altering the way the BBB works via transport enhancers to allow vitamin/minerals uptake in the brain.
Again. Could you give an example?
Apolipoprotein E, Cyclosporine A, verapamil, PPQ, curcumin, phosphatidylserine, lipid-based nanoparticles used in chemo, etc, etc, etc...
Thank you
L-Threonate as recommended by Dr Dale Bredensen
M-o-ggy,
I think that molecules either do or don't cross the blood brain barrier (BBB). Melatonin would be an example of a molecule that can cross the BBB. Something like mannitol can potentially disrupt the blood brain barrier allowing some molecules to pass the blood brain barrier that might normally not be able to. This would be different than what you are describing though because in this case mannitol is not helping a specific molecule cross the BBB, but rather allowing many molecules to cross the BBB somewhat like a broken fence on a ranch allowing many animals that should not be on the outside to get to the outside and similarly, this would not be a good thing if the fence or BBB remained open too long.
Art
Hi there, The broken fence analogy is my thought.
You mentioned supplements that can help other vitamins/minerals cross the blood brain barrier. Many supplements can be complexed together with something else that will allow the supplement to cross the BBB and or more easily pass into tissues and these can be nano formulations or liposomal formulations. Not every supplement is available this way, but more and more are being developed as time passes.
Art
One thing I have wondered about is since magnesium threonate supposedly crosses the blood brain barrier if a person was taking other supplements at the same time would some of them cross the b-b barrier?
I doubt it, because in this form of magnesium the magnesium is mixed with the vitamin c metabolite threonic acid to form a salt, magnesium l-threonate
Art
What would we do without you explaining everything to us Art???
I wish I knew everything, because then I would put it altogether and find the cure! Unfortunately, I do not.☹️
Art
Hello
By chance, would you know of any supplements that would cross the BBB that could remove alpha-synuclein?
I take astaxanthin and was wondering if there are more effective solutions
Thanks very much for your time with this
BR
Melatonin can help reduce alpha synuclein assembly, fibril formation, toxicity and aggregation .
Art
thank you so very much.
BR
Are you asking about this for dementia or PD?
Art
I have been diagnosed with Multiple System Atrophy
"Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease arising from the misfolding and accumulation of the protein α-synuclein in oligodendrocytes, where it forms glial cytoplasmic inclusions (GCIs)."
There's no cure but I am trying to find ways to reduce the alpha-synuclein via BBB apart from the Astaxanthin I am taking
Thanks much for checking in
Kindest regards
BR
MSA, like PD involves significantly elevated oxidative stress levels and inflammation, mitochondrial dysfunction and mitophagy dysfunction. If you can tolerate melatonin, it works to try and normalize these deficits along with its corrective activity of alpha synuclein.
Endoplasmic reticulum stress (ERS) plays a part in early MSA disease initiation and melatonin also works to reduce ERS.
Autophagy is also impaired in MSA neurons and melatonin, as a smart molecule can modulate autophagy. I just wrote about that aspect of melatonin as it related to PD here :
healthunlocked.com/cure-par...
Curcumin is also an inhibitor of asyn :
pubs.acs.org/doi/pdf/10.102...
Art
Immense thanks for the suggestions and your time with it .
I will most certainly give both melatonin and curcumin a try
You have been very kind
Much appreciation
BR
Some people are not able to tolerate melatonin, and if you fall into that category, I wrote about how to increase melatonin levels naturally and this way seems to eliminate most, if not all side effects . Here is a link to that :
healthunlocked.com/cure-par...
Good luck and post if you have any questions !
Art
I suspect both melatonin and curcumin may possibly induce bioavailable copper deficiency over time with regular use. Be careful of melatonin, and just in case, please visit the following thread and stop use if you notice any massive gastric distress and diarrhea.
PEA is said to beable to pass the blood brain barrier because of its particles are treated to be small enough to be absorbed.There are some curcumin supplements that are treated similar.y( at least that’s what the blurb says.)
This may be apples-and-oranges but nilotinib is medication designed to stop drugs from leaking through the BBB. I had a DAT scan that says I have PD. But do I have a deficiency or leakage of dopamine through the BBB?
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