Gabapentin could it work for you? - Cure Parkinson's

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Gabapentin could it work for you?

Bailey_Texas profile image
22 Replies

i am taking 200 mg of Gabapentin 3 times a day. I no longer have any Parkinson's pain. I had pain in my hands feet and legs and arms mainly when i was off. Now i do not have any pain when i am on or off. it also increased how long my meds last. My meds now last 4 to 6 hours. I take 3 25/100 and 1 50/200 24 hour release Carbadops/levadopa every 4 hours 24/7. l also stopped taking Ropinirole. I don't know what effect that had. I have not had any depression or sad time for the last week. I was having depression or sad time almost every day. I think the ropinirole was the cause of it. I am sleeping better. I am not having any side effects. I do tend to rock back and forth when i am setting. But just a little but it does not bother me. I do not feel sleepy as much during the day. Gabapentin has changed my life. I think everyone here should try it.

The photo is me about to start a 1 mile walk. The bar bell weighs 95 pounds.

I am 64 12 years diagnosed with Parkinson's. I have all symptoms of Parkinson's except tremor.

Has anyone here had a similar reaction using Gabapentin.

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Bailey_Texas
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silvestrov profile image
silvestrov

Gabapentin for Parkinsonism: A Double-Blind, Placebo-controlled, Crossover Trial

amjmed.com/article/S0002-93...

Greenday profile image
Greenday in reply tosilvestrov

Silvestrov, given all those positive reports, do you believe that Gabapentin is a safer alternative for long term pain management compared to NSAID drugs?

Do the positive effects of Gabapentin relate to the Gamma-aminobutyric acid (GABA) which has similar structure?

Does supplementation with natural anti-anxiety agents such as GABA, Taurine and L-Theanine exert similar effect to Gabapentin?

Latest research ncbi.nlm.nih.gov/pmc/articl... indicate that a-synuclein aggregation may equally affect GABA receptors as well as dopamine receptors.

* Parkinson's disease (PD) as a selective damage of dopaminergic neurons should be updated into the concept of a severe multisystemic neurodegenerative disorder of the nervous system, whose clinical symptoms reflect the localization and progression of the most advanced GABA pathology. *

Why the medical community have shown less interest in this aspect of the disease which affects the daily life of millions of PD patients?

I personally find it very insulting to all those patients that go though such suffering and pain due to the lack of knowledge of the disease from many of the "professionals" and the availability of possible treatments; GABAergic and Dopaminergic treatments should go along!

silvestrov profile image
silvestrov in reply toGreenday

I have known of a total of 3 people who tried Gabapentin. 1 person suffered with horrible depression and memory loss; another claimed gabapentin helped her but she had a history of drug abuse which is problematic as we shall see. And Bailey responded well to the drug and I am happy for him. But what are some of the possible side effects

of gabapentin?

"Additional side effects of Neurontin abuse may include:"

Weight gain, Dizziness, Fatigue, Runny nose, Fever, Headaches, Memory loss, Tremors

Double vision, Dry mouth, Muscle aches, Nausea, Impaired motor functions

"The FDA also warns that one in 500 people who take Neurontin may experience suicidal thoughts."

"Many report that it produces a “zombie-like” effect, hence the “Morontin” moniker."

futuresofpalmbeach.com/neur...

Having looked at gabapentin I am weary of it and other GABA analogues like pregabalin and phenibut:

Gabapentin and pregabalin: abuse and addiction.

ncbi.nlm.nih.gov/pubmed/228...

Phenibut:

Phenifucked - My Descent into Phenibut Induced Hell on Earth - Part 1

drugs-forum.com/journal/phe...

So if you are not having any side effects from GABA analogues, you are fortunate.

Since I have no need for GABA analogues I am content with using Theanine because

it is quite safe and has many positive effects on the human body including:

bolstering the immune system: telegraph.co.uk/news/scienc...

It offers PD neuroprotection: greenmedinfo.com/article/l-...

It reduces anxiety: ihpmagazine.com/l-theanine-...

It protects the liver: sciencedirect.com/science/a...

Finally:

The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness.

ncbi.nlm.nih.gov/pubmed/210...

I looked into whether theanine could help with neuropathic pain (like gabapentin)

and could not find any evidence supporting this idea and others have

investigated this matter:

L-Theanine, a better alternative to Gabapentin and Pregabalin?

bluelight.org/vb/threads/63...

When I first heard that Bailey was responding well I too assumed it modulated his

GABA levels and here is a GABA/PD study:

CSF GABA levels in Parkinson's disease.

ncbi.nlm.nih.gov/pubmed/669...

It is interesting that GABA levels were normalized by by L-dopa and

anicholinergics (it is an old study).

Another study notes that a:

Direct link between GABA activation and dopamine suppression

news-medical.net/news/20120...

But this does not explain Bailey's positive response so it is a matter of conjecture.

I guess we are back to square 1.

Bottom line is, like every other drug therapy for PD, results may vary and it you are having neuropathic pain perhaps gabapentin may help. Of course, there are other possible therapies to try prior to using the drug.

Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial onlinelibrary.wiley.com/doi...

Alpha-Lipoic Acid Improved Polyneuropathy Symptoms diabeticmctoday.com/HtmlPag...

I have posted this before but it is good to know:

Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease.

"Most notably, we found that when combined, LA and ALC worked at 100-1000-fold lower concentrations than they did individually. "

ncbi.nlm.nih.gov/pubmed/?te...

I enjoy learning new things and surprise, surprise, guess what I found?

Supinita, Gabapentin/ Methylcobalamin/ Alpha Lipoic Acid

10 tab Gabapentin 100mg/ Methylcobalamin 0.5mg/ Alpha Lipoic Acid 100mg

buy-pharma.md/Supinita-Gaba...

And a supplement with methylcobalamin, alpha lipoic acid, thiamine, folate and pyridoxine:

dmpharma.co.in/Mecobalamin,...

Both appear to be manufactured in India.

Greenday profile image
Greenday in reply tosilvestrov

Silvestrov, thank you very much for your research and your elaborate answer . Your active contribution to the community is well appreciated.

Neuropathy is an often overlooked symptom of PD.

Your list of supplements is a multi-approach regimen against the disease and quite interesting as well healthunlocked.com/parkinso...

You mention that you take 5 ibuprofen (NSAID) a week.

Is it because of the pain caused by a neuropathy?

It is interesting that Bailey stopped taking Ropinirole prior to Gabapentin, a dopamine agonist that includes dizziness and drowsiness as side effects. I wonder whether the combination of those 2 drugs could exacerbate those symptoms

silvestrov profile image
silvestrov in reply toGreenday

I take ibuprofen prior to sleep because my body feels better upon waking with little to no body aches. Several years ago I fought off osterarthritis - not PN, I caught OE early, and my joints feel better after taking ibu.. I think ibuprofen is the best NSAID for PD for several reasons.

Antidepressant and antioxidative effect of Ibuprofen in the rotenone model of Parkinson's disease.

ncbi.nlm.nih.gov/pubmed/247...

Ibuprofen or piroxicam protects nigral neurons and delays the development of l-dopa induced dyskinesia in rats with experimental Parkinsonism: Influence on angiogenesis

europepmc.org/abstract/med/...

The second study begs the question whether taking low dose ibuprofen with levodopa could prevent/reduce dyskinesia? Ibuprofen helps me but I try to limit my its consumption to 5 days a week (and take a yearly 10 day 'holliday' to limit the side effects. The best way to take ibuprofen is the liquid/children's formula because it is safer for the stomach and will minimize ulcer risks. NSAIDS I do not like are Tylenol/acetaminophen and sodium naproxen. Years before I was exposed to chemicals and experienced a parkinson's-like syndrome, my job aggrevated my many joint problems and the Dr placed me on (then) prescription horse pill sodium naproxen and I shook like a leaf with bilateral shaking - both arms were simultaneously affected. I had to take a different job until the prescription was complete and then I returned to 'normal'.

Exacerbation of idiopathic Parkinson's disease by naproxen

bmj.com/content/311/7002/422.3

I am not found of using Tylenol because it depletes glutathione from the liver and if someone should intentionally/unintentionally OD their life will be saved by having n-acetyl cysteine (NAC) injected into them. Otherwise their liver would be destroyed and they would die.

Acetaminophen Toxicity Treatment & Management

emedicine.medscape.com/arti...

Other people on this site have spoke favorably about ibuprofen use but it has to be used with caution.

Recently I discovered that taking 100 mg of caffeine (or a cup of coffee) with 200 mg ibuprofen has synergistic pain killing effect:

Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults

Cochrane.org/CD011509/SYMPT...

Have a good week and I need to get back at updating a section of my documentary.

Rich

PS. Ibuprofen also reduces PD risk.

hsph.harvard.edu/news/press...

Greenday profile image
Greenday in reply tosilvestrov

Rich thank you again for your valuable information and useful references. You always bring something new in the discussion

DEAT profile image
DEAT

So happy for you Bailey. Thanks for sharing this news with us.

You continue to be an inspiration to me.

Regards Denise

Bazillion profile image
Bazillion

Hi Bailey great to see you posting and with a positive result ! I tried Pregabalin but it didn’t agree with me so didn’t take it long enough to know if it helped.. perhaps will ask to try Gabapentin.

bassofspades profile image
bassofspades

Interesting!! Im looking in to it now

Kia17 profile image
Kia17

Thank you for sharing your experiences and inspiring us. You are doing great Bailey. Keep it up.

Greenday profile image
Greenday

A strong power of will! An inspiration for the rest!

Bailey_Texas profile image
Bailey_Texas

i am taking a low dose of gabapentin. 2400 mg is the largest a person should take in one day.

Dantheman2 profile image
Dantheman2 in reply toBailey_Texas

I think I have taken 3 times this in one day with no side effects. Of course I am an addict so I run out and the withdrawal is HORRIBLE

bassofspades profile image
bassofspades

Got my Rx! Starting real low.

Bailey_Texas profile image
Bailey_Texas in reply tobassofspades

I started with 100mg 3 times a day and now i am taking 200mg 3 times a day. It is still working. Imm get a full 4 hours of relief on each does .

bassofspades profile image
bassofspades in reply toBailey_Texas

Dr starting me on 100mg per day, building up to 300 in 3 weeks and we'll take it from there. Thanks for the advice. Ive been reading alot and this sounds kinda promising.

Bailey_Texas profile image
Bailey_Texas in reply tobassofspades

Good luck

JimColdguy profile image
JimColdguy

I was given gabapentin for a nerve pain episode that had me in bed for 4 weeks (BAD!!!) I noticed it made the Mucuna Pruriens I take for PD work better and last longer. I take 200 mg three times a day. I had to change docs because my PCP would not prescribe it for me. With the reality that PD is progressive and unrelenting, I would eat wood if it made me feel and function better. So for now, GP is a part of my daily attempt to live a "normal" life. And, for now, it works. Not a cure, not a solution for the long run, but for now...

Dantheman2 profile image
Dantheman2

I too cannot believe how amazing I respond. Motivated, confident, outgoing and pain free

Rosabellazita profile image
Rosabellazita

I was prescribed gabapentin today for sleep . One each night at 300 mg each. I read the side effects and one concerns me more than the others and that would be damaging of I don't I don't know whether to take this stuff or not!

Rosabellazita profile image
Rosabellazita in reply toRosabellazita

Damaging of organs is what I meant to type.

Bailey_Texas profile image
Bailey_Texas in reply toRosabellazita

i stopped taking it about a week ago. I would be so stiff after sleeping i could hardly move and i was not able to keep an erection. Now both problems are gone.

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