Swelling

[Marcia123]

Has anyone had swelling and rashes? I have swelling of my right calf and knee and above and am developing scaly rashes.

[park_bear]

This is not a PD symptom. You should probably get yourself to an urgent care clinic or the ER no later than tomorrow. That said, how long has this been going on? Any redness with the swelling?

[Marcia123 in reply to park_bear]

It has been gradually getting worse over the last 6 months and the swelling behind my knee makes it hard for me to straighten my leg to walk.

[park_bear in reply to Marcia123]

OK, so it may not quite the emergency I feared but nonetheless you need to get medical attention for this as soon as possible. This is not a PD symptom.

[marilw]

I developed edema of the legs and rashes as a side effect to Miraplex which I no longer take.

[Farooqji]

This is contact dermatitis. Nothing to do with PD. use acyclovir ointment to treat

[park_bear in reply to Farooqji]

For starters, Acyclovir is antiviral drug and therefore not appropriate for a contact dermatitis. Next, poster is not complaining of itching and redness which throws your diagnosis into question. Finally, this could be something serious so she really needs medical attention.

[silvestrov]

Marcia,

Let's suppose you have contact dermatitis (CD) and here are a few thoughts about CD.

I am familiar with contact dermatitis and have investigated it for a 24 yo friend. The most common form of contact dermatitis is the nickel allergy and it affects twice as many woman as men.

Quite recently the source of inflammation for nickel allergies has been identified:

Toll like receptor 4.

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

nature.com/articles/ni.1919

So a TLR4 inhibitor needs to be taken to lessen histamine/cytokine release from mast cells.

Quercetin negatively regulates TLR4 signaling induced by lipopolysaccharide through Tollip expression.

ncbi.nlm.nih.gov/m/pubmed/2...

Quercetin Is More Effective than Cromolyn in Blocking Human Mast Cell Cytokine Release and Inhibits Contact Dermatitis and Photosensitivity in Humans

journals.plos.org/plosone/a...

Considering you may have 2 unrelated?? conditions, PD & a skin condition, you want a supplement which may be used on both and quercetin is that supplement.

Quercetin & PD.

ncbi.nlm.nih.gov/m/pubmed/1...

To be effective, quercetin should be taken on an empty stomach and when do you take L-dopa? On an empty stomach - so quercetin can be taken with L-dopa.

Another supplement good for a nickel allergies is vitamin C. When taken with food, it binds to nickel and chelates it - grabs hold of and removes nickel from the food. Say 1,000 mg of vitamin C with every meal.

"In addition to avoiding foods that are high in nickel, Dr. Zirwas tells patients to take vitamin C with every meal because it will bind to the nickel in the food and prevent absorption."

dermatologytimes.modernmedi...

"CONCLUSIONS: Whereas vitamin C has a strong link with Parkinsonism, the potential role of zinc has only been suspected."

ncbi.nlm.nih.gov/m/pubmed/2...

Let's just say for the moment that you do not have a nickel allergy and have another form of dermatitis. The pro inflammatory cytokine (protein) involved in atopic dermititis is interleukin-17 (IL-17).

Establishing a Role for Interleukin-17 in Atopic Dermatitis-Related Skin Inflammation.

"CONCLUSIONS: IL-17 may mediate AD-related immune dysregulation by amplifying the inflammatory response."

ncbi.nlm.nih.gov/m/pubmed/2...

Q: what supplement is good for both atopic dermatitis/IL-17 and PD?

A: ursolic acid

Ursolic acid IL-17:

Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein

ncbi.nlm.nih.gov/pmc/articl...

Ursolic acid & PD:

google.com/search?q=ursolic...

Either contact dermatitis or not, vitamin C, quercetin, and ursolic acid are potential PD therapies so it is a no lose proposition to take them.

Best wishes.

Rich

[aspergerian]

See also omega-3, etc.

umm.edu/health/medical/altm...

sciencedaily.com/releases/2...

[LauraL]

My swelling has been brought to the attention of my neurologists and personal physicals in two different states. I have been given 20 mg Lasex and Hydrochloraside at different times but nothing helped. My swelling is in both legs from below the knee to the ankle and occasionally the feet. I had DBS to stop my tremor on my right side 11 years ago and am scheduled for my left side June 3rd. Of course in 11years my symptoms have progressed and rather than mirroring the right side which worked wonderfully, the surgeon is aiming to control my tremor and difficulty walking.

Does anyone else live with the swelling on a daily basis.