Agent clears toxic proteins and improves cognition in PD - LCB-03-110

[aspergerian]

Agent clears toxic proteins and improves cognition in neurodegeneration models

sciencedaily.com/releases/2...

[Xenos]

Thanks Aspergerian. There is another, simpler, way to target the process of autophagy, and that's periodic fasting...

[aspergerian]

Have you a citation or several?

[Xenos in reply to aspergerian]

I do. Read this "Short-term fasting induces profound neuronal autophagy" Here :

ncbi.nlm.nih.gov/pubmed/205...

or here :

researchgate.net/publicatio...

and many others like :

researchgate.net/publicatio...

[aspergerian]

Thank you. I'LL be reading with pd orexin leptin cites in mind. Fun stuff!

[aspergerian in reply to aspergerian]

Indeed, autophagy and mitophagy seem important to PD. It is not clear to

me if and how autophagy induced by short-term fasting will

efficaciously target impaired neurons in PD.

Autophagy and disease: always two sides to a problem.

ncbi.nlm.nih.gov/pubmed/219...

"In this review, we focus on several pathological conditions associated

with primary or secondary defects in autophagy and comment on a

recurring theme for many of them, ie the fact that autophagy can often

exert both beneficial and aggravating effects on the progression of

disease. Elucidating the factors that determine the switch between these

dual functions of autophagy in disease has become a priority when

considering the potential therapeutic implications of the

pharmacological modulation of autophagy in many of these pathological

conditions."

[aspergerian]

Regarding ketogenic diet, see:

Ketosis & Parkinson's Disease: Improving Symptoms with a Ketogenic Diet.

8 minute video by David Perlmutter, MD.

youtube.com/watch?v=8raIvT8...(Not working as expected?)