Mitochondria, lysosomes, alpha-synuclein, PD

[aspergerian]

Two areas of PD research overlap: mitochondria and lysosomes (1-4).

Even the MJF Foundation is involved (5). See also: (6-10). Insights

from interactions among mitochondria, lysosomes, and mitophagy may

lead to beneficial therapeutics. Will anything helpful be found

among supplements and nutrients? Don't know, but Costantini's B1

therapy addresses mitochondrial function. Technical citations. More research is needed.

1.

healthunlocked.com/parkinso...

2.

healthunlocked.com/api/redi...

3. Loss of Mitochondrial Function Impairs Lysosomes.

J Biol Chem 2016 May 6;291(19):10263-76.

ncbi.nlm.nih.gov/pubmed/269...

4. Neuronal Mitophagy in Neurodegenerative Diseases.

Front Mol Neurosci 2017 Mar 8;10:64.

ncbi.nlm.nih.gov/pubmed/283...

"Dysfunctional cellular proteolytic systems have been linked

extensively to neurodegenerative diseases (ND) like Alzheimer's

disease (AD), Parkinson's disease (PD), or Huntington's disease

(HD), with autophagic failure being one of the main factors

contributing to neuronal cell death in these diseases."

5. Targeting the Lysosomal Pathway to Ease Mitochondrial Dysfunction

in IPSC-Derived Neurons from People with Parkinson's and GBA

Mutations

MJFF Target Validation, 2016

michaeljfox.org/foundation/...

6. Parkin and PINK1 function in a vesicular trafficking pathway

regulating mitochondrial quality control.

EMBO J 2014 Feb 18;33(4):282-95.

ncbi.nlm.nih.gov/pubmed/244...

7. PINK1/Parkin-Dependent Mitochondrial Surveillance: From

Pleiotropy to Parkinson's Disease.

Front Mol Neurosci 2017 May 1;10:120.

ncbi.nlm.nih.gov/pubmed/285...

8. PINK1, Parkin, and Mitochondrial Quality Control: What can we

Learn about Parkinson's Disease Pathobiology?

J Parkinsons Dis 2017;7(1):13-29.

ncbi.nlm.nih.gov/pubmed/279...

9. Mitochondrial lipids in neurodegeneration.

Cell Tissue Res 2017 Jan;367(1):125-140.

ncbi.nlm.nih.gov/pubmed/274...

10. The ubiquitin signal and autophagy: an orchestrated dance

leading to mitochondrial degradation.

EMBO Rep 2016 Mar;17(3):300-16.

ncbi.nlm.nih.gov/pubmed/268...

11. TMEM175 deficiency impairs lysosomal and mitochondrial function

and increases α-synuclein aggregation.

Proc Natl Acad Sci USA 2017 Feb 28;114(9):2389-2394.

ncbi.nlm.nih.gov/pubmed/281...

12. Lysosomes and α-synuclein form a dangerous duet leading to

neuronal cell death.

Front Neuroanat 2014 Aug 14;8:83.

ncbi.nlm.nih.gov/pubmed/251...

.

[Astra7]

Some light bedtime reading! Thanks for posting these links. Perhaps there is hope for us yet.

[parkie13]

Boy, this is going to take a while

[aspergerian]

The intersection of lysosome and microglia includes studies of

gangliosides and GM1, a topic already discussed on this listserv.

13. GM1 ganglioside in Parkinson's disease: Pilot study of effects

on dopamine transporter binding.

J Neurol Sci 2015 Sep 15;356(1-2):118-23.

ncbi.nlm.nih.gov/pubmed/260...

14. A randomized, controlled, delayed start trial of GM1 ganglioside

in treated Parkinson's disease patients.

J Neurol Sci 2013 Jan 15;324(1-2):140-8.

ncbi.nlm.nih.gov/pubmed/231...

15. Common and uncommon pathogenic cascades in lysosomal storage

diseases.

J Biol Chem 2010 Jul 2;285(27):20423-7.

ncbi.nlm.nih.gov/pubmed/204...

16. Enhanced autophagy and mitochondrial aberrations in murine

G(M1)-gangliosidosis.

Biochem Biophys Res Commun 2008 Mar 14;367(3):616-22.

ncbi.nlm.nih.gov/pubmed/181...

[Gioc in reply to aspergerian]

... pearls of wisdom almost lost ... like tears in the rain "

thanks you Aspergerian