One thing that has happened to me since I started Sinemet is that my depression has left. Most all the time I'm actually happy. I'm very grateful for this. It's such a wonderful feeling after being so depressed for so very long.
My GP says it's because no matter how much serotonin you have it can not work without the dopamine. I've been able to cut back on the anti-depressants significantly. I not longer take Trazodone or Wellbutrin and I'm only on 100mg of Zoloft now which is a reduction for me. Earlier this year I was on 150 Trazodone, 300 Wellbutrin and 150 Zoloft.