Sinemet

[Annie81963]

Is there anyone who is on or has been on sinemet that can tell me about any side effects they may have had or are now experiencing. Thanks 😊

[rustjudge]

I have endured constipation, nocturia, insomnia, dry mouth , and dyskinesias. I have reduced my sinemet intake and it has abated some of the aforementioned problems.

JSJ

[Kachimom in reply to rustjudge]

For dry mouth I read that brushing your teeth and mouth wash help with that. I have tried both at different times and they do help.

[Kachimom]

I have been on Sinimet for about a year now, after taking several other PD meds. Sinimet has done the most for me but the one side effect that really bothers me is Dyskenisia. I also feel that taking it with food helps to keep the Dyskinesa at bay. Extended release Sinimet works good for me. Along with the Sinimet, I take Amatidine.

[paddyfields in reply to Kachimom]

Taking sinemet with food/protein will reduce the amount of available dopamine which might indicate you are on too high a dose of sinemet. Just a thought.

[dewey098 in reply to Kachimom]

I agree with this advice. In terms of cause and effect, there appears to be a direct connection between taking (too much???) Sinemet and Dyskinesa.

[Trenny]

I have been on increasing doses of sinemet and have reached one three times a day, which I have to stay on for two or three weeks . If I don't have any side effects, or benefit, I then have to increase by half a tablet daily up to three times daily.

I have been feeling very tired in the evenings and could quite easily go to bed at 9pm or before. I do notice a dry mouth at night. I still sleep quite well, but get up several times and think there is a degree of urinary retention.

I am going to ask the consultant if I can have a long-acting form as I have difficulty remembering to take the afternoon dose at about 2pm. I take the third dose at about 6 or 7 pm.

[Annie81963]

Thank you everyone who responded. I've been on it for years and was wondering if anyone has any side effects.

[dianegale]

i have been on it for two years and it works great for my polymiositis. i am almost normal but the dowm side is that it wears off 3 and a . half to 4 hours and the next dose takes 20 mimutes to 1 and a half hours to take effect. when it is workingi stay busy but its hard at night time to stay busy . i find my mood effects it also