Hi I have been diagnosed with microscopic colitis I was was put on steriods for a year but these didn't help, I just running to toilet especially in a morning I can go 5.6 times in the first hour on getting out of bed, Now my consultant has decided to try me on Azathioprine starting on 50mg 2wks then 50mg 2 weeks other than me feeling very anxious and tired nothing seems to of helped me yet so now it's been decided to start me on 150mg, Omg. Anybody out there who take this medication and has it helped? I am very worried at the moment with this coronavirus as this medication lowers the immune stytem alot. Looking forward to hearing from you.
Azathioprine : Hi I have been diagnosed... - Crohn's and Colit...
I have been on 150 mg per day for over 15 years, and for the most part have been in remission for the whole time. I now suffer with c rather than d, but that's for other reasons (opiates for another unrelated illness). There are some, like me, who swear by these pills, there are others who swear at them. Take care.
I have been on azathioprine for around 18 months - although it has helped I do still have ongoing inflammation.
Re your start, this based on my experience does not seem correct, the dose should be around 2.5mg (I think) per Kg of body mass.
150mg I guess seems more reasonable but it takes around 6 weeks to get the TGN level into the therapeutic zone - have you had regular bloods to check for liver function?
I started on 125mg then 150mg as I was not therapeutic but at this point my liver suffered so was dropped to 37.5mg with allopurinol, which in combination increases bioavailibity so the dose can be lowered.
Maybe you need to discuss with the nurses, there is an NHS booklet on azathioprine which is pretty good.
Hi there Azathioprine can take a while to start showing results. I take it myself but it's early days for me but my Brother who has Crohns has been on it years and swears by it. You should be having regular blood tests while on this medication also I have been told to self shield as it is a immune suppressant.
My son has been on 150mgs for a few years and has blood tests every 3 months.
It has been the most successful medication so far but he still has to use the loo when he first gets up a few times.
He was offered higher dose but preferred to keep it as low as possible and puts up with ear'y morning loo visits as long as his day is mostly loo free.
He does use Cavilon cream to stop his bottom being sore, available on prescription.
His specialist nurse app was yesterday and he got a call instead of going to the hospital.
He has had the NHS letter to tell him to stay at home for 12 weeks.
Not sure if this will help - I had problems with keep going to the toilet and watery diarrhea for a while and it was so bad I wouldn't eat all day when at work. I was eventually diagnosed with ulcerative colitis and put on salofalk granules daily . Years on my bowel is free of ulcers and I hardly get flare ups. x
Hi, I was on azathioprine for best part of ten years to treat my Crohns until in Feb 2018 I was diagnosed with bowel cancer. Look at the potential side effects of azathioprine. For all the time I took it, it kept me well. I think it takes three months to be fully in your system. I am off it now since my cancer, I had my resection in April 2018 and have not been on medication since! Recently had a flare up, intestines so inflamed that I had to have steroids. Good luck with the azathioprine but ready the paperwork.
Thank you for your advice, I am very aware of the side affects that's what's worrying me I sometimes think would it be better to suffer the times I have to rush to toilet rather than be so anxious about what this tablet can do to you, I think it's not helped with all this that's going on even though I am self isolating but I still have to go get my bloods done. You staf safe.
Hello, I was on 125 mg. Of azathioprine for almost 20 years. I started taking it in 2000 and stopped in 2019. It did help but I still had issues for the first few years I was on it and had a bowel resection surgery in 2008. Since my surgery I have been Ok and have only had a few flare ups. So the azathioprine worked much better for me after my surgery. It does suppress the immune system in order to keep the inflammation caused by Crohn's down but I didn't get sick more often due to that. I stopped taking azathioprine last year because there are better medications available now. I am now on Entyvio which are IV infusions. There is also Stelara. With this covid 19 virus I would ask about an alternative to azathioprine just to be safe. Hope this helps.....