What topics or questions would you like to dis... - CLL Support
What topics or questions would you like to discuss or learn about? Please ask the group about anything that comes to mind.
i HAVE NEED TO KNOW OF EXTREMELY SENSITIVE MARKERS FOR CLL PROGRESSI
ANY ALSO SELECTIVE FOR CLL ?
Hi I am not sure I understand your question. Dr Samir Agrawal has recently updated his article on diagnosis for the CLLSA website this helps explain how it is determined.
cllsupport.org.uk/01%20Agra...
Cytogenics/prognostics have been written about by Professor Andy Pettitt
cllsupport.org.uk/prognosti...
He has also recently had his article on treatment updated by Dr Anna Schuh
cllsupport.org.uk/05%20Trea...
I have posted below a current information post on the topic, which highlighted to me the importance of our international community. Can you add a little more information to your question?
Defining the prognosis of early stage chronic lymphocytic leukaemia patients.
“Doc , how long do I have”
updates.clltopics.org/4336-...
What can newly diagnosed CLL patients expect?
Abstract
Defining the prognosis of early stage chronic lymphocytic leukaemia patients.
ncbi.nlm.nih.gov/pubmed/221...
Excerpt
“Multivariate analysis revealed that only LDT, IGHV mutation status, CD38 and age at diagnosis were independent prognostic variables for TTFT and OS. Therefore, IGHV mutation status and CD38 expression have independent prognostic value in early stage CLL and should be performed as part of the routine diagnostic workup. ZAP-70 expression and FISH were not independent prognostic markers in early stage disease and can be omitted at diagnosis but FISH analysis should be undertaken at disease progression to direct treatment strategy.”
It is important to note that all markers other than IgHV, can change over time.
Here is a brief listing of the IgHV family of genes seen in CLL...
IgHV gene mutation varies in CLL. These tests are NOT done clinically.
Here are some examples:
Stereotype #2 V3-21 mutated or unmutated, poor prognosis, antigentic stimulation by coffin-1, high frequency del 11q23.
Stereotype #8 V4-39, unmutated, surface IgG, poor prognosis, antigenic stimulation by vimentin, 24 fold risk of Richter's transformation, high frequency of trisomy 12.
Stereotype #4 V4-34, mutated, good prognosis, presentation at young age (~43), antigenic stimulation by Ii blood group.
Stereotype #16 V4-34, mutated, good prognosis - though not as good as #4.
Stereotype #1 V1-5-7, unmutated, poor prognosis, antigenic stimulation by vimentin.
Stereotype #5 V1-69, umutated, antigenic stimulation by coffin-1, favorable prognosis.
Stereotype #6 V1-69, unmutated, antigenic stimulation by non-muscle myosin heavy chain, prognosis intermediate.
These are being studied by researchers...
~chris
