I got this further information from the doctor. Can anybody interpret it for me?

[Fred_Green]

I learned that I am IGHV mutated / TP53 unmutated, then received the following additional results without much commentary. Is anybody able to help interpret them?

- Chromosome Microarray Analysis (CMA) was performed on this bone marrow sample using 8x60K oligonucleotide arrays (Agilent) to screen for genome imbalances associated with CLL as only limited FISH testing was possible in this sample.

- A male genome was identified harbouring 9Mb loss at 13q14.11q14.3 regions (housing the RB1, DLEU1, DLEU2 & DLEU 7 genes among others.) indicative for standard risk CLL.

- In addition, FISH analysis of 100 cells using dual color/dual probe (Cytocell) confirmed the CMA data by showing a normal diploid signal pattern for the ATM and TP53 gene regions

[Spark_Plug]

You're sitting pretty well for a CLL patient! Non-professional opinion, but you want mutation for IVIG, and no mutations for specific critical areas. The TP 53 is a snag but many have announced the same status and have have reasonably good results. I'll let them give you the skinny on that matter I am unsure of all the technicalities.

🙂

[Shepherd777 in reply to Spark_Plug]

TP 53 may be as low as 2 per cent or 75 percent and higher. My wife was at 50 per cent TP 53 in 2015 and was on watch an wait for a year until she hit 75 percent and they began to treat her in 2017. The novel agents (pills) like Imbruvica, Venetoclax and Acalabrutinib have put her into remission twice and she is still in remission now. Many of the CLL specialists believe my wife with the new meds will die with CLL and not from CLL.

[Skyshark]

You aren't in a low risk CLL group but in standard risk.

13q14

ncbi.nlm.nih.gov/pmc/articl...

ncbi.nlm.nih.gov/pmc/articl...

ashpublications.org/blood/a...

The extent of deletion into RP1 is not a good sign - this is why you are standard risk.

I'm not sure if 9Mb loss is small or large but it is greater than the median, ranges start at a few 100Kb exceed 100Mb.

FISH Diploid means that both arms of the chromosome are intact. There is no loss of 11q (includes ATM) or 17p (TP53).

I don't know and can't find anything about 11q14.3 related to CLL.

[spi3]

There is good news regarding the current immunetheropy's, my husband is TP53 muted and 17p depleted, however, using Acalabrutrinib &Veneclax for the last two years (initially he had Obinutuzumab infusions) has made his CLL lesser in risk. I call his pills his warrior Angels.

[Fred_Green]

Thats great spi3 !