lymph node swelling

[sbkris1]

Hi Everyone,

I haven’t posted in a while. I have cll diagnosed in 2019.

Now with with decent labs but lately my arm pits have been super itchy with what seems like lymph nodes swelling and enlarged.

Have not had this before.

My oncologist seems unconcerned. Should I be concerned about this?

Anybody have any ideas?

Thanks

[Ellieoak]

how have your counts been? Are they elevated? Usually before I start feeling the lymph nodes enlarged my count goes up.

[sbkris1 in reply to Ellieoak]

Hi Ellieoak

My lymphocyte absolute count is 12.5

WBC 14.5

[HelloCLL in reply to sbkris1]

Hello. Your numbers look great to me. Perhaps you have become allergic to deodorant or other things, like laundry detergent? My skin has developed sensitivity issues since diagnosis. Best wishes to you. 🧡❤️

[Shedman in reply to sbkris1]

I see that your alc was 70 in 2019..Have I got this wrong? - are your numbers not going backwards?

SLL presentation sees swollen lymph nodes as an early typical sign, but can arise with any CLL..

Also sign of infection or vaccination response.

[Skyshark]

Have you have had a recent vaccination?

[lankisterguy Volunteer]

Hi sbkris1,

The NIH has several papers suggesting that CLL itself leads to skin issues, as noted here:

ncbi.nlm.nih.gov/pubmed/174...

SNIP: "Cutaneous lesions occur in up to 25% of patients with chronic lymphocytic leukemia (CLL). These can be caused by either cutaneous seeding by leukemic cells (leukemia cutis, LC) and other malignant diseases or nonmalignant disorders. Skin infiltration with B-lymphocyte CLL manifests as solitary, grouped, or generalized papules, plaques, nodules, or large tumors.....The most common secondary cutaneous changes seen in CLL are those of infectious or hemorrhagic origin. Other secondary lesions present as vasculitis, purpura, generalized pruritus, exfoliative erythroderma, and paraneoplastic pemphigus. An exaggerated reaction to an insect bite and insect bite-like reactions have been also observed".

Here is a 2023 article on how the immune system reacts to skin injury or causes autoimmune reactions:

the-scientist.com/news-opin...

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Len