What is next if Acalabrutinib AFIB wont stop?

[barger1951]

My heart wasn't in the best of shape (2 valves replaced) to start with when I started on Ibrutinib. Ibrutinib really exacerbated my AFIB, but after a year of Ibruitinb, I was off all medication for almost 3 years......until the CLL started to get more aggressive.

My doctor put me on Acalabrutinib and the AFIB came back with a vengeance and I had a harder time going on walks and exercising. The doctor just told me to stop taking it and wants to meet with me to discuss "what's next".

'What's next' has me a little nervous and I am not sure what else she has in mind. Anyone with a similar type deal going on?

Cheers,

Barger1951

[studebaker]

sorry about your ordeal. I was on Acalabrutinib for 8 months when atrial fibrillation experience hit me first time. I was cardioverded, but another AF hit me few weeks later and the cardio version took care of it only for a week or so and I ended with permanent AF and a heart failure.

My next treatment which I am still on is Rituximab/Venetoclax for two years and even though my heart problems are still present and under care of cardiologist, I hope for long remission after February when I finish.

I wish you well and hopefully all will be sorted out for you soon.

Dana

[barger1951 in reply to studebaker]

Thanks Dana

[AussieNeil Administrator in reply to barger1951]

Depends where you live - and whether any clinical trials are available to you. Ventoclax + obinutuzumab is another possibility (obinutuzumab is a later generation, more effective version of rituximab). Venetoclax monotherapy is also a possibility, as is chlorambucil + obinutuzumab, with or without the chlorambucil, which is a very old 'chemo' treatment and which doesn't add much to the combination, but is how obinutuzumab was FDA approved.

Neil

[barger1951 in reply to AussieNeil]

thanks, great info!

BARGER1951

[GIDI]

My husband was also told to stop Ibrutinib after heart failure and was put on Venetoclax monoterapy for 2 years. He is now already 3 years on remission, although it looks like the CLL is crawling back. He will return to Venetoclax I suppose.

Best wishes

Annette

[barger1951 in reply to GIDI]

thanks Annette

[LeoPa]

Probably V+O.

[Test_Tech]

Hello barger1951,

Prior to my treatment I had to have two ablation procedures due to AFIB. So when I needed to start treatment I chose to be treated with Obinutuzumab and Venetoclax instead of Ibrutinib or Acalabrutinib. I was lucky enough to have a choice. I had no AFIB issues during my treatment due to the low probability of Obinutuzumab causing AFIB.

Good Luck

Everett

[barger1951 in reply to Test_Tech]

thanks Everett

[SLLJOHN in reply to Test_Tech]

Just to clarify the ablation procedures were successful. I have heard of stories where they work for a few days only. I am about to see a consultant to consider one…..

[Test_Tech in reply to SLLJOHN]

The first was successful until I had a tear in my Mitral valve, when the heart specialist went in to repair the Mitral valve he performed a second Ablation procedure and I have had no problems since.

Good Luck Casio1

Everett