Too many antibodies?

[Ozziebee]

I finally got my oncologist to order Evusheld for me. I have been tested for antibodies and I do have some. I am still on watch and wait as well. Is it possible to have too many antibodies? Will it overload the immune system? I heard a very well-known CLL doctor claim that you can’t have too many antibodies but I wanted to reach out to this group for some opinions as well.

What do you think?

[Miee]

Hi Ozziebee:

My IgG level is higher than normal range, so I was afraid that high immune response against corona vaccination might occur. Actually, I got a high fever (39 C) after corona vaccination, although I am not sure that it is attributed to higher IgG level. That's all. There was no problem in daily life.

Miee

[SofiaDeo]

I don't think this is enough information. "I made some antibodies" as opposed to where on the testing range you fall. Your age, which is a factor as the older we are, the less reactive/responsive our immune system can be. Your general overall health. Any reactions to previous immunizations. Liver function. Any other liver metabolized medications. Any other disease states. Environmental stressors (are your lungs stressed from wildfire smoke, or mold/mildew from constant flooding? )There are a lot of factors to consider, and your doctor is probably the best person to assess this at an individual level.

At a population level, doctors are saying "immune compromised people need all the help they can get". That being said, there is also discussion as to "how many immunization shots are too many". But I am not seeing any information as to what happens if there are "too many antibodies". I do know that there are a few diseases where our body makes too many immune globulins. But the Covid pandemic is new, we really don't have any data as to the effects of "lots of vaccinations/antibody injections".

If you "speak medical" at all, this basic tutorial discusses how antibodies are cleared, and possible side effects of them in general. It might help you with your (very personal) decision.

ncbi.nlm.nih.gov/pmc/articl...

All this being said, I personally am continuing with immunizations, and getting Evusheld next week. I am under treatment, I don't have a high level of inflammation in my body. I eat clean, have clean water, don't have serious imbalances in body systems (no kidney or liver issues, normal weight and no excessive visceral fat, good lung function, more muscle than average for my age). I stay inside when the air quality is bad outdoors. I am not exercising like I should, but am working my way back to it after being ill for months with a pneumonitis. I personally think my risk of adverse reaction to extra antibodies in my body is lower than the largely unknown risk of Covid.

I would rather deal with medication reaction than risk Covid infection.

[Pin57]

I’d ask your doc regarding your score and your question.

For what it’s worth, one data point n feedback on it … my docs, both CLL n PCP, we’re not concerned that I had too many antibodies (I’m in LLS Study n latest spike antibodies result last week was 19,714 U/ml).

I have not needed to get Evusheld, been lucky to get good antibodies scores from the past 3 Phizer vaccine shots. I’m on W&W, no treatment yet.

Hope Evusheld did well for you. Just know… Antibodies scores don’t tell the level of protection one has no matter what the score may be, so stay safe!

[Ozziebee in reply to Pin57]

When I had an antibody test after the second booster, I had 16,400 result. So I definitely got a response. I am also 69 years old so have a lesser immune system because of that. I’ve been so looking forward to being able to get Evusheld but now for some reason I’m worried about overloading my system. My doctor has ordered it so he doesn’t seem too concerned.

[Pin57 in reply to Ozziebee]

Wow … you’ll probably soar past that new LabCorp max range (25,000) adding in Evusheld.

I see why your asking the “overload” question … but your doc appears on-board with what your doing and I haven't heard of an overload score (if one even exists?).

Good luck going forward!

[LeoPa]

I don't think so. They give Evusheld to those who form no antibodies or form very little of them right? So it is unlikely that the antibodies contained in Evusheld would get your antibody levels to a dangerous level if there is such a thing at all.

[Bikram21]

I am in the exact position on W&W with >2500 antibodies and asked my specialist the same question. I was told to get it because Evusheld is not about producing antibodies. It’s more about not allowing the virus to get into the cells. I picture it as a protection covering the cells which does not allow the virus access.

[Ozziebee]

Thanks!