Neutrophils low

[Sheng]

Start Calquence from Aug 2021.

Neutrophils changed from 2.2xE9/L before start Drug to 1.0 after one month then slowly back to 1.8 at end of Nov.

so Doc change my blood test to 6 weeks, but after the 6 weeks blood test result Neutrophils change to 0.6, and the WBC form 4.0 xE9/L change to 2.6.

Did any one experience this too? any reason can cause this, have Doc appointment tomorrow, what should I ask him?

Thanks from Seng

[AussieNeil Partner Founder Admin]

Hi Sheng,

The manufacturers have updated advise to cover severity/grade 3 (0.5 to 0.99 and severity 4 (under 0.5) neutropenia, "with infection or fever" here:

imbruvicahcp.com/cll/dosing...

When I accessed the above today (4th January 2022), the recommendation, which could change in the future, was "to interrupt until improvement to grade 1 or baseline". Grade/severity level 1 neutropenia is between 1.5 and the lower reference limit, which is usually between 1.8 and 2.0, depending on your pathology laboratory.

Neil

[Sheng in reply to AussieNeil]

thanks for information, will read it.

[LeoPa]

Check with the doc if you can suspend it for a few weeks to see if it helps.

[Sheng in reply to LeoPa]

thanks, I will ask